Zusammenfassung
Bei 31 (30 nichtverwandten) Patienten mit idiopathischer Hämochromatose wurde der HLA-Phänotyp bestimmt und mit dem Verteilungsmuster der HLA-Antigene in der deutschen Bevölkerung verglichen. Dabei fand sich ein signifikanter Überschuß von HLA-A3 (76,7% gegen 30,2%). Auch die Häufigkeit von HLA-B7 war erhöht (53,3% gegen 27,0%), erreichte jedoch bei Korrekturen für multiple Vergleiche nicht ganz die Signifikanzgrenze. Die Befunde stehen in Übereinstimmung mit Beobachtungen für andere ethnische Gruppen und sprechen dafür, daß IH in erhöhtem Maße mit dem Haplotyp A3/B7 vergesellschaftet ist.
Summary
HLA-phenotypes were determined in 31 (30 unrelated) patients with hemochromatosis and compared to the distribution of HLA-antigens in the general German population. A significant excess of HLA-A3 was observed (76.7% vs. 30.2%). The frequency of HLA-B7 was also increased (53.3% vs. 27.0%). However, the difference did not quite reach the level of statistical significance, when correction for multiple comparisons was made. Our finding are in accord with previous observations for different ethnic groups, indicating an association of IH with the A3/B7 haplotype.
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Dyrszka, H., Eberhardt, G. & Eckert, G. The distribution of HLA-antigens in german patients with idiopathic hemochromatosis. Klin Wochenschr 57, 529–531 (1979). https://doi.org/10.1007/BF01487823
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DOI: https://doi.org/10.1007/BF01487823