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Über das Lactatdehydrogenase-erhöhende Virus in Laboratoriumsgeschwülsten

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Zusammenfassung

Ein fermentstimulierendes Virus aus Mäusegeschwülsten wird beschrieben, das ohne weitere pathogene Wirkung auf Zelle oder Organismus den Serumfermentspiegel besonders der Lactatdehydrogenase bei Mäusen dauernd wesentlich erhöht. Dieses sog. Lactatdehydrogenase-Agens oder Riley-Agens ist in fast allen Laboratoriumsgeschwülsten der Maus, die dauernd transplantiert werden, enthalten. Der Effekt auf die Serum-LDH ist nur eine Eigenschaft des Virus, die auch seinen einfachen Nachweis gestattet. Die wesentliche noch weiter zu klärende Bedeutung des Virus scheint in der Möglichkeit einer Stimulation von Geschwulstwachstum zu liegen.

Summary

Review about an encyme elevating virus (Riley agent) derived from murine tumors, which stimulates plasma levels mainly of the lactic dehydrogenase without any pathogenic effect on cells or organs of infected mice. The lactic dehydrogenase agent (Riley) is associated with practically all laboratory tumors of mice which are kept on continuous transplantations. The effect on the plasma LDH is only one attribute of the virus simultaneously representing a simple methode of virus demonstration. The more essential, yet unproved attribute is the question of its stimulating or synergistic effect on tumor growth.

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Literatur

  1. Adams, D. H., K. E. K. Rowson, andM. H. Salaman: The effect of tumors, of leukemia and of some viruses associated with them on the plasma lactic dehydrogenase activity of mice. Brit. J. Cancer15, 860 (1961).

    Google Scholar 

  2. Bayerle, H., A. Georgh u.P. Jakob: Über das Verhalten des Lactatdehydrenase aktivierenden Virus aus Mäusegeschwülsten bei der Autolyse. Z. Krebsforsch.65, 171 (1962).

    Google Scholar 

  3. Bayerle, H., A. Georgh u.K. E. Richard: Über die Aktivität von Serumfermenten nach zellfreier Beimpfung mit Ehrlichschem Mäusetumorascites. Klin. Wschr.40, 920 (1962).

    Google Scholar 

  4. Bladen jr., H. A., andA. L. Notkins: Electron microscopic demonstration of the lactic dehydrogenase agent. Virology21, 269 (1963).

    Google Scholar 

  5. Blancher, M. C., P. T. Green, J. P. MacLean, andM. J. Hollenberg: Plasma lactic dehydrogenase and phosphohexose-isomerase in leukemia. Blood13, 245 (1958).

    Google Scholar 

  6. Brdiczka, D., A. Georgh u.H. Zobl: Die Wirkung von Nucleinsäuren aus virushaltigen Mäusegeschwülsten auf die Lactatdehydrogenaseaktivität im Blutserum. Naturwissenschaften50, 306 (1963).

    Google Scholar 

  7. Crispens, C. G.: A lactic dehydrogenase elevating agent in association with human neoplasms. Nature (Lond.)199, 1202 (1963).

    Google Scholar 

  8. Crispens, C. G.: Serum lactic dehydrogenases levels in mice during the development of autochtonous and chemically induced tumors. J. nat. Cancer Inst.30, 361 (1963).

    Google Scholar 

  9. Erickson, R. J., andD. R. Morales: Clinical use of lactic dehydrogenase. New Engl. J. Med.265, 478, 531 (1961).

    Google Scholar 

  10. Friend, C., andF. Wroblewski: Lactic dehydrogenase activity of serum in mice with transplanted leukemia. Science124, 173 (1956).

    Google Scholar 

  11. Georgh, A.: Die Aktivitätsänderung der Lactatdehydrogenase im Serum nach Infektion mit Geschwulstvirus der Maus als Regulationsstörung in vivo. Verh. dtsch. Ges. Path.46, 357 (1962).

    Google Scholar 

  12. Georgh, A., H. Bayerle, D. Brdiczka u.H. Zobl: Über ein die Lactatdehydrogenase im Serum aktivierendes Virus aus Geschwülsten der Maus. Z. Krebsforsch.65, 334 (1963).

    Google Scholar 

  13. Georgh, A., u.D. Brdiczka: Die Überlebenszeit des Lactatdehydrogenaseagens aus Mäusegeschwülsten in Fibroblastenkulturen bei längerer Inkubation. Z. Krebsforsch. (im Druck).

  14. Georgh, A., P. Goldbrunner u.D. Brdiczka: Der Einfluß von p-Aminosalicylat bei der Nucleinsäuresisolierung auf das Lactatdehydrogenase aktivierende Virus des Mäusetumors Sarkom I. Naturwissenschaften51, 66 (1964).

    Google Scholar 

  15. Georgh, A., M. Jäger, H. Kroth u.H. Bayerle: Aktivitätsänderungen der Lactatdehydrogenase im Mäuseplasma durch Beeimpfung mit virushaltigen Geschwulstfiltraten oder virushaltigen Gewebekulturen. Experientia (Basel)18, 71 (1962).

    Google Scholar 

  16. Georgh. A., H. Kroth u.H. Bayerle: Weitere Untersuchungen über die Aktivierung der Lactatdehydrogenase im Serum durch ein Geschwulstvirus der Maus. Klin. Wschr.40, 363 (1962).

    Google Scholar 

  17. Georgh, A., andI. Lenz: Failure to propagate a lactic dehydrogenase-elevating agent from mice tumors in mice embryo cultures. Nature (Lond.) (im Druck).

  18. Georgh, A., I. Lenz, andH. Zobl: Behaviour of the lactic dehydrogenase-elevating agent (Riley) in mouse-embryo-cultures following inoculation in utero. Proc. Soc. exp. Biol. (N.Y.) (im Druck).

  19. Hill, B. R., andR. T. Jordan: Serum lactic dehydrogenase activity in mice with transplantable leukemia. Cancer Res.17, 144 (1957).

    Google Scholar 

  20. Hill, B. R., andC. Levi: Elevation of a serum component in neoplastic diseases. Cancer Res.14, 513 (1954).

    Google Scholar 

  21. Kelly, R., andD. Greiff: The level of lactic dehydrogenase activity as an indicator of the growth of influenca virus in the embryonic egg. J. exp. Med.113, 125 (1961).

    Google Scholar 

  22. Lenta, S. M. P., andS. M. A. Riehl: Dehydrogenase studies of tissue from normal and tumor-bearing mice. II. Lactic and malic dehydrogenases. Cancer Res.9, 47 (1949).

    Google Scholar 

  23. Mahy, B. W., C. W. Parr, andK. E. K. Rowson: Increased plasma isomerase and transaminase activity in mice infected with lactic dehydrogenase-elevating virus. Nature (Lond.)198, 885 (1963).

    Google Scholar 

  24. Manso, C., K. Sugiura, andF. Wroblewski: Glutathione reductase and lactic dehydrogenase activities of tissue of rodents with transplanted tumors. Cancer Res.18, 682 (1958).

    Google Scholar 

  25. Mundy, J., andP. C. Williams: Transmissible agent associated with some mouse neoplasms. Science134, 834 (1961).

    Google Scholar 

  26. Notkins, A. L., R. J. Berry, J. B. Moloney, andR. E. Greenfield: Relationship of the lactic dehydrogenase factor to certain murine tumors. Nature (Lond.)193, 79 (1962).

    Google Scholar 

  27. Notkins, A. L., andR. E. Greenfield: Infection of tumor-bearing mice with the lacticdehydrogenase agent. Proc. Soc. exp. Biol. (N.Y.)109, 988 (1962).

    Google Scholar 

  28. Notkins, A. L., R. E. Greenfield, D. Marshall, andL. Bane: Multiple enzyme changes in the plasma of normal and tumor-bearing mice following infection with the lactic-dehydrogenase agent. J. exp. Med.117, 185 (1963).

    Google Scholar 

  29. Notkins, A. L., andC. Scheele: An infectious nucleic acid from the lactic dehydrogenase agent. Virology20, 604 (1963).

    Google Scholar 

  30. Notkins, A. L., andS. J. Sochat: Studies on the multiplication and the properties of the lactic dehydrogenase agent. J. exp. Med.117, 735 (1963).

    Google Scholar 

  31. Plagemann, P. G. W., M. Watanabe, andH. E. Swim: Plasma lactic dehydrogenase-elevating agent of mice: Effect of levels of additional enzymes. Proc. Soc. exp. Biol. (N.Y.)111, 749 (1962).

    Google Scholar 

  32. Rauen, H. M., u.H. Hupe: Das Lactatdehydrogenase-Agens im Blute tumortragender Mäuse. Arzneimittel-Forsch. (Drug Res.)13, 1933 (1963).

    Google Scholar 

  33. Riley, V.: Virus-Tumor synergism. Science134, 666 (1961).

    Google Scholar 

  34. Riley, V.: Synergistic glycolytic activity associated with transmissible agents and neoplastic growth. J. gen. Physiol.45, 614 (1962).

    Google Scholar 

  35. Riley, V.: Synergistic glycolytic activity associated with transmissible agents and neoplastic growth. In: Control mechanisms in respiration and fermentation. Bethesda: Ronald Press Co. 1963.

    Google Scholar 

  36. Riley, V.: Evidence for a minute infectious entity. Proc. Amer. Ass. Cancer Res.4, 57 (1963).

    Google Scholar 

  37. Riley, V., E. Huerto, F. Lilly, D. Bardell, J. D. Loveless, andM. A. Fitzmaurice: Some characteristics of virus-like entities associated with thirthy varieties of experimental tumors. Proc. Amer. Ass. Cancer Res.3, 261 (1961).

    Google Scholar 

  38. Riley, V., E. Huerto, J. D. Loveless, D. Bardell, M. Fitzmaurice, andC. Forman: Inapparent transmissible agents in oncology and their influence on tumor and host. Acta Un. int. Cancr.19, 263 (1963).

    Google Scholar 

  39. Riley, V., E. Huerto, J. D. Loveless, D. Bardell, M. Fitzmaurice, andC. Forman: Role of viruses in the biochemical and pathological behavious of tumor and host. VIII. Intern. Cancer Congr. Moscow 1962.

  40. Riley, V., F. Lilly, E. Huerto, andD. Bardell: Transmissible agent associated with 26 types of experimental mouse neoplasms. Science132, 545 (1960).

    Google Scholar 

  41. Riley, V., J. D. Loveless, M. Fitzmaurice, andM. L. Eidinoff: Preliminary studies on size of lactic dehydrogenase elevating virus-like agents. (Im Druck).

  42. Riley, V., andF. Wroblewski: Serial lactic dehydrogenase activity in plasma of mice with growing or regressing tumors. Science132, 151 (1960).

    Google Scholar 

  43. Rowson, K. E. K., D. H. Adams, andM. H. Salaman: Riley's enzyme elevating virus: A study of the infection in mice and its relation to virus induced leukemia. VIII. Intern. Cancer Congr. Moscow 1962.

  44. Rowson, K. E. K., B. W. J. Mahi, andM. H. Salaman: Size estimation by filtration of the enzyme elevating virus ofRiley. Life Sci.7, 479 (1963).

    Google Scholar 

  45. Schwartz, M. A., M. West, W. S. Walsh, andH. Zimmerman: Serum enzymes in disease. VIII. Glycolytic and oxydative enzymes and transaminase in patients with gastrointestinal carcinoma. Cancer (Philad.)15, 346 (1962).

    Google Scholar 

  46. Tsirimbas, A., K. Krikellis u.W. Stich: Über die Heterogenität der Serum-Laktatdehydrogenase bei menschlichen Leukämien. Klin. Wschr.40, 878 (1962).

    Google Scholar 

  47. Yaffe, D.: The distribution and in vitro propagation of an agent causing high plasma lactic dehydrogenase activity. Cancer Res.22, 573 (1962).

    Google Scholar 

  48. Zobl, H.: Über Vorkommen und Vermehrung des Lactat-Dehydrogenase erhöhenden Agens in Mäusegeschwülsten. Inaug.-Diss. München 1964.

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Authors and Affiliations

  1. Aus dem Pathalogischen Institut der Universität München, Germany

    A. Georgh

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Durchführung der eigenen Arbeiten mit Unterstützung der Deutschen Forschungsgemeinschaft.

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Georgh, A. Über das Lactatdehydrogenase-erhöhende Virus in Laboratoriumsgeschwülsten. Klin Wochenschr 42, 559–563 (1964). https://doi.org/10.1007/BF01487782

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