Summary
The concentration of ionized calcium in plasma decreases during haemodialysis when a dialysate calcium concentration of 5 mg-% is used, but increases with a bath calcium concentration of 6 mg-% or more. Postdialysis plasma ionized calcium concentrations reach normal levels with a bath calcium concentration of 7 mg-%. The protein-bound calcium concentration in plasma increases during dialysis with all 3 bath calcium concentrations.
These results are discussed in connection with possible implications for the pathogenesis of renal osteodystrophy.
Zusammenfassung
Während der Hämodialyse vermindert die Konzentration des ionisierten Calciums im Plasma, wenn Waschwasser mit einer Calciumkonzentration von 5 mg-% benutzt wird; sie steigt aber an bei einer Bad-Calciumkonzentration von 6 mg-% oder mehr. Bei einer Waschwasser-Calciumkonzentration von 7 mg-% erreicht die Konzentration des ionisierten Calciums im Plasma nach der Dialyse den Normalwert. Die Konzentration des an Proteinen gebundenen Calciums steigt an in jedem Falle.
Die Bedeutung dieser Änderungen für die Pathogenese der Osteodystrophie chronisch dialysierter Patienten wurde diskutiert.
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References
Ettori, J., Scoggan, S. M.: Metal ions in biological systems. A determination of pM by spectrophotometry of metal indicators at two wavelengths. Arch. Biochem.78, 213 (1958).
Fournier, A. E., Johnson, W. J., Taves, D. R., Beabout, J. W., Arnaud, C. D., Goldsmith, R. S.: Etiology of hyperparathyroidism and bone disease during chronic hemodialysis. I. Association of bone disease with potentially etiologic factors. J. clin. Invest.50, 592 (1971).
Fournier, A. E., Arnaud, C. D., Johnson, W. J., Taylor, W. F., Goldsmith, R. S.: Etiology of hyperparathyroidism and bone disease during chronic hemodialysis. II. Factors affecting serum immunoreactive parathyroid hormone. J. clin. Invest.50, 599 (1971).
Genuth, S. M., Sherwood, L. M., Vertes, V., Leonards, J. R.: Plasma parathormone, calcium and phosphorus in patients with renal osteodystrophy undergoing chronic hemodialysis. J. clin. Endocr.30, 15 (1970).
Kaye, M., Mangel, R., Neubauer, E.: Studies in calcium metabolism in patients on chronic haemodialysis. Proc. Europ. Dialysis Transplant Assoc.3, 17 (1966).
Prasad, A. S.: Studies on ultrafiltrable calcium. Arch. intern. Med.105, 560 (1960).
Reiss, E., Canterbury, J. M., Kanter, A.: Circulating parathyroid hormone concentration in chronic renal insufficiency. Arch. intern. Med.124, 417 (1969).
Sachs, C. H., Bourdeau, A. M., Broyer, M., Balsan, S.: Le calcium ionisé au cours de l'hémodialyse dans l'insuffisance rénale chronique. Ann. Biol. clin.28, 137 (1970).
Sherwood, J. M., Mayer, G. P., Ramberg, C. F., Kronfeld, D. S., Aurbach, G. D., Potts, J. J.: Regulation of parathyroidhormone secretion: proportional control by calcium, lack of effect of phosphate. Endocrinology83, 1043 (1968).
Verberckmoes, R.: Dosage de la fraction ultrafiltrable du calcium par une méthode utilisant le rein artificiel de type twin coil. Proc. Europ. Dialysis Transplant Assoc.3, 28 (1966).
Wing, A. J.: Optimum calcium concentration of dialysis fluid for maintenance haemodialysis. Brit. med. J.1968 II, 145.
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Verberckmoes, R. Study on the influence of dialysis with varying bath calcium concentrations on the different plasma calcium fractions. Klin Wochenschr 50, 480–482 (1972). https://doi.org/10.1007/BF01487606
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DOI: https://doi.org/10.1007/BF01487606