Skip to main content
SpringerLink
Log in

Langzeitbeobachtungen zur Frage von Gastrointestinalblutungen durch Acetylsalicylsäure

Gastrointestinal blood loss due to acetylsalicylic acid (long-term study)

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

Blood loss after administration of acetylsalicylic acid (Aspirin or Colfarit) was investigated in 9 patients. Aspirin/Colfarit (1.5 g/d) was given twice for periods of 14 days within 50 days. With each of the drugs blood loss was less than 5% of total blood volume within the test period. Microhemorrhages were observed in 5 patients. As blood loss is minimal (less than 0.2% of blood volume per day), it may be neglected in clinical use.

Zusammenfassung

Bei 9 Versuchspersonen wurde der Blutverlust innerhalb von 50 Tagen mit zwei 14tägigen Einnahmeperioden von Aspirin (1,5 g/d) bzw. Colfarit (1,5 g/d) bestimmt. Bei keinem der beiden Präparate konnte ein Blutverlust von mehr als 5% des Gesamtblutvolumens innerhalb der Einnahmeperiode festgestellt werden. Über die gesamte Meßperiode sind Sickerblutungen bei 5 Personen gefunden worden. Wegen des geringen Ausmaßes (unter 0,2% des Gesamtblutes pro Tag) können sie bei der therapeutischen Anwendung in der Regel außer Betracht bleiben. Die Ergebnisse werden anhand der Literatur diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Blahd, W. H.: Nuclear medicine. New York: The Blakiston Division. McCraw-Hill Book Company 1965.

    Google Scholar 

  2. Bouchier, J. D. A., Williams, H. S.: Determination of faecal blood-loss after combined alcohol and sodium-acetylate intake. Lancet1969 I, 178–180.

    Google Scholar 

  3. Bowie, E. I. W., Owen, C. A., Jr.: Aspirin, platelets and bleeding. Circulation40, 757–760 (1969).

    Google Scholar 

  4. Bothwell, Th. H., Finch, C. A.: Iron metabolism, 1. ed. London: J. & A. Churchill Ltd. 1962.

    Google Scholar 

  5. Brown, R. K., Mitchell, N.: The influence of some salicyl compounds (and alcoholic beverages) on the natural history of peptic ulcer. Gastroenterology31, 198 (1956).

    Google Scholar 

  6. Chapman, B. L., Duggan, I. M.: Aspirin and uncomplicacted peptic ulcer. GUT10, 443–450 (1969).

    Google Scholar 

  7. Cooke, A. R., Goulston, K.: Failure of intravenous aspirin to increase gastrointestinal blood loss. Brit. med. J.1969 330–332.

  8. Davenport, H. W.: Gastric mucosal hemorrhage in dogs (Effects of acid, aspirin, alcohol). Gastroenterology56, 439–449 (1969).

    Google Scholar 

  9. —— Potassium fluxes across the resting and stimulated gastric mucosa: injury by salicylic and acetic acids. Gastroenterology49, 238–245 (1965).

    Google Scholar 

  10. Ebaugh, F. C., Clemens, T., Rodnan, G., Peterson, R. E.: Quantitative measurement of gastrointestinal blood loss I.: The use of radioactive51Cr in patients with gastrointestinal hemorrhage. Amer. J. Med.25, 169–180 (1958).

    Google Scholar 

  11. Gast, L. F.: Influence of aspirin on haemostatic parameters. Ann. rheum. Dis.23, 500–504 (1964).

    Google Scholar 

  12. Grossmann, M. J., Matsumoto, K. K., Lichter, R. J.: Fecal blood loss produced by oral and intravenous administration of various salicylates. Gastroenterology40, 383–388 (1961).

    Google Scholar 

  13. Kelly, J. J., Jr.: Salicylate ingestion: a frequent cause of gastric hemorrhage. Amer. J. med. Sci.232, 119–127 (1956).

    Google Scholar 

  14. Lange, E. H. F.: Salicylate and gastric hemorrhage. II. Manifest bleeding. Gastroenterology33, 778–788 (1957).

    Google Scholar 

  15. Leonhard, J. R.: Aspirin and gastrointestinal blood-loss. Gastroenterology44, 617–619 (1963).

    Google Scholar 

  16. Parry, D. J., Wood, Ph. H. N.: Relationship between aspirin taking and gastroduodenal hemorrhage. GUT8, 301–307 (1967).

    Google Scholar 

  17. Pierson, R. N., Holt, P. R., Watson, R. M., Keating, R. P.: Aspirin and gastrointestinal bleeding (chromate-51 blood-loss studies). Amer. J. Med.31, 259–264 (1961).

    Google Scholar 

  18. Roche, M., Perez-Gimenez, M. E., Layrisse, M., Di Prisco, E.: Study of urinary and fecal excreation of radioactive Cr-51 in man. Its use in the measurement of intestinal blood loss associated with hookworm infection. J. clin. Invest.36, 1183–1192 (1957).

    Google Scholar 

  19. Scharrer, I., Schepping, M., Breddin, K.: Thromboseprophylaxe mit Aspirin? Der Einfluß von Acetylsalicylsäure auf die Thrombozytenaggregation in vitro und in vivo. Klin. Wschr.47, 1318–1324 (1969).

    Google Scholar 

  20. Stephens, F. O., Milverton, E. J., Hably, C. K., Ven, E. K. van der: The effect of food on aspirin induced gastrointestinal blood-loss. Digestion1, 267–276 (1968).

    Google Scholar 

  21. Thorsen, W. B., Western, D., Tanaka, Y., Norrissey, J. F.: Aspirin injury to the gastric mucosa. Arch. intern. Med.121, 499–506 (1968).

    Google Scholar 

  22. Valman, H. B., Parry, D. J., Coghill, N. F.: Lesions associated with gastroduodenal hemorrhage in relation to aspirin intake. Brit. med. J.1968, 661–663.

  23. Smith, V. M., Babb, R. R.: Acetylsalicyclsäure: Ursache akuter Gastrointestinalblutung? Eine Betrachtung. Fortschr. Med.87, 1153–1157 (1969).

    Google Scholar 

  24. Weiss, A., Pitmann, E. R., Graham, E. C.: Aspirin and gastric bleeding (Gastroskopic observations with reviews of literature). Amer. J. Med.31, 266–278 (1961).

    Google Scholar 

  25. Werner, E., Kaltwasser, J. P., Becker, Hj.: Quantitative Bestimmung von Blutverlusten mit dem Ganzkörperzähler. In Vorbereitung.

Download references

Author information

Authors and Affiliations

  1. Zentrum der Inneren Medizin, Abteilung für Hämatologie der Universität Frankfurt a. M. und der Gesellschaft für Strahlenforschung, Abteilung für Biophysikalische Strahlenforschung, Frankfurt a. M.

    J. P. Kaltwasser & E. Werner

Authors
  1. J. P. Kaltwasser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Werner
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Wir danken der Firma Bayer, Leverkusen, für die Überlassung von Versuchsmengen Aspirin und Colfarit.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaltwasser, J.P., Werner, E. Langzeitbeobachtungen zur Frage von Gastrointestinalblutungen durch Acetylsalicylsäure. Klin Wochenschr 49, 927–930 (1971). https://doi.org/10.1007/BF01485217

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01485217

Key-words

Schlüsselwörter

Search

Navigation