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Hemmung des generalisierten Sanarelli-Shwartzman-Phänomens bei Kaninchen durch Induktion einer passiven Endotoxintoleranz

Inhibition of the generalized Sanarelli-Shwartzman reaction by passive induction of endotoxin tolerance

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Summary

The generalized Sanarelli-Shwartzman reaction (GSSR) and the known decrease of platelets and of the coagulation factors I, V, VII and VIII after the second injection of lipopolysaccharid was significantly inhibited in rabbits pretreated with serum from endotoxin-tolerant rabbits. Maximal protection against the GSSR and the decrease of platelets was conferred by serum fractions of tolerant animals obtained by gelfiltration on Sephadex G-200, containing the macromolecular fraction I.

Zusammenfassung

Die vorliegenden Untersuchungen zeigen, daß eine Übertragung von Serum endotoxintoleranter Kaninchen vor der präparativen Endotoxininjektion bei den Empfängertieren signifikant die Entwicklung eines generalisierten Sanarelli-Shwartzman Phänomens und den nach der zweiten Lipopolysaccharidinjektion einsetzenden Abfall der Thrombocyten und der Gerinnungsfaktoren I, V, VII und VIII hemmt. Ebenso schützt eine Übertragung der durch Gelfiltration auf Sephadex G 200 aus dem Serum endotoxintoleranter Kaninchen abgetrennten großmolekularen Fraktion I die Empfängertiere vor der Entwicklung eines generalisierten SSP und vor dem nach der zweiten LPS-Injektion einsetzenden Thrombocytenabfall.

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Literatur

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Authors and Affiliations

  1. Medizinische Universitätsklinik und Pathologisches Institut der Universität Freburg i. Br., Germany

    D. Böttcher, H. Kasemir, L. Kerp & C. Mittermayer

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  1. D. Böttcher
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  2. H. Kasemir
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  3. L. Kerp
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  4. C. Mittermayer
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Böttcher, D., Kasemir, H., Kerp, L. et al. Hemmung des generalisierten Sanarelli-Shwartzman-Phänomens bei Kaninchen durch Induktion einer passiven Endotoxintoleranz. Klin Wochenschr 50, 341–342 (1972). https://doi.org/10.1007/BF01485186

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  • DOI: https://doi.org/10.1007/BF01485186

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