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Die gemischte Lymphocytenkultur in der immunologischen Spenderauswahl

The mixed leucocyte culture for immunological donor selection

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Summary

The mixed leucocyte culture is an important test in the immunologic donor selection. It is particularly suited to find identical living donors within the family. The in vitro homograft reaction serves as a good indicator for the immunological reaction in vivo. The method and its advantages and disadvantages are described; its scope of application in the field of transplantation is discussed, including also the author's own observations.

Zusammenfassung

Die gemischte Leukocytenkultur (MLC) ist ein wichtiger Test in der immunologischen Spenderauswahl. Sie ist besonders geeignet, um identische Lebendspender innerhalb der Familie zu finden. Als Abstoßungsreaktion in vitro gibt sie einen guten Hinweis auf zu erwartende Immun-reaktionen in vivo. Die Methodik und ihre Vor- und Nachteile werden beschrieben, ihre Anwendungsmöglichkeit bei verschiedenen Transplantationen wird, auch anhand eigener Beispiele, diskutiert.

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  1. Abteilung Immunologie am Institut für Hämatologie der Gesellschaft für Strahlen- und Umweltforschung München, Germany

    W. Mempel

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Mempel, W. Die gemischte Lymphocytenkultur in der immunologischen Spenderauswahl. Klin Wochenschr 50, 287–295 (1972). https://doi.org/10.1007/BF01485176

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