Summary
Administration of human growth hormone to 2 patients (severe growth retardation, operative panhypopituitarism) resulted in a significant reduction of the urinary excretion of adrenaline and tentatively increase of urinary excretion of noradrenaline.
Zusammenfassung
Zufuhr von menschlichen Wachstumshormon resultierte bei 2 Patienten (hypophysärer Zwergwuchs, operativ bedingter Panhypopituitarismus) in einer signifikanten Verminderung der Adrenalin-Ausscheidung und möglichem Anstieg der Noradrenalin-Ausscheidung.
References
Anton, A. H., Sayre, D. F.: A study of the factors affecting the aluminium oxide-trihydroxyindole procedure for the analysis of catecholamines. J. Pharmacol. exp. Ther.138, 360 (1962).
Hökfelt, B.: Noradrenaline and adrenaline in mammalian tissues. Acta Physiol. Scand.25, Suppl. 92 (1951).
Hopsu, V. K.: Effects of experimental alterations of the thyroid function on the adrenal medulla of the mouse. Acta Endocrinol. Suppl. 48 (1960).
Kitabchi, A. E., Williams, R. H.: Epinephrine synthesis in Cushing's syndrome. J. Clin. Endocr.28, 1082 (1968).
Margolis, F. L., Roffi, J., Jost, A.: Norepinephrine methylation in fetal rat adrenals. Science154, 275 (1966).
Shapiro, S.: Interaction between growth hormone and cortisol on the regulation of liver tyrosine transaminase activity. Endocrinology83, 475 (1968).
Shapiro, S., Yuwiler, A., Geller, E.: Maturation of a stress-activated mechanism inhibiting induction of tyrosine transaminase. Science152, 1642 (1966).
Wurtmann, R. J., Axelrod, J.: Adrenaline synthesis: Control by pituitary gland and adrenal glucocorticoids. Science150, 1464 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
v. Studnitz, W. Effect of growth hormone on urinary excretion of catecholamines in man. Klin Wochenschr 48, 245–246 (1970). https://doi.org/10.1007/BF01485072
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01485072