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Untersuchungen zur biliären Elimination von Enzymen

II. Verhalten von Lactatdehydrogenase, Hydroxybutyratdehydrogenase, Creatin-Phosphokinase, Glutamat-Oxalacetat-Transaminase und Glutamat-Pyruvat-Transaminase

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Zusammenfassung

GOT, GPT, LDH und HbDH finden sich in der menschlichen Lebergalle in Konzentrationen, die den Serumspiegeln entsprechen. Die 24 Std-Ausscheidung beider Transaminasen zeigt ebensogute Korrelation wie die von LDH und HbDH. CPK läßt sich nur sporadisch in der Galle nachweisen. Für die Enzyme GOT, GPT, LDH, Cpl und (teilweise) AP wird eine biliäre Elimination aus dem Serum postuliert, für GlDH, OCT und G-6-PD ist die Leber als ausschließlicher Ursprungsort der biliären Aktivitäten anzusehen.

Summary

GOT, GPT, LDH, and HbDH occur in human bile and serum at equal levels. The daily excretion of GOT versus GPT and LDH versus HbDH shows good correlation. CPK is rarely found in bile. Biliary elimination from serum is claimed for GOT, GPT, LDH, Cpl and AP, whereas liver parenchyma is considered as exclusive source for GlDH, OCT, and G-6-PD in bile.

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Authors and Affiliations

  1. I. Medizinische Klinik der Medizinischen Akademie Lübeck, Germany

    Klaus Lorentz, Gabriele Jaspers & Johannes Adlung

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  1. Klaus Lorentz
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  2. Gabriele Jaspers
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  3. Johannes Adlung
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Lorentz, K., Jaspers, G. & Adlung, J. Untersuchungen zur biliären Elimination von Enzymen. Klin Wochenschr 48, 218–220 (1970). https://doi.org/10.1007/BF01485061

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