Summary
Successful treatment of missed abortion and intrauterine fetal death by intravenous administration of prostaglandin F2α (PGF2α) in 13 patients is reported. Infusion of up to 100 µg/min of PGF2α resulted in regular uterine contractions within the first two hours. In contrast, cervix dilatation did not occur until paracervical blockade was given. Undesirable side effects, such as nausea and vomiting occurring almost regularly could be treated without difficulty, but in our opinion they preclude routine application of this method.
Current further investigations on other applications of Prostaglandins might be promising.
Zusammenfassung
Es wurde über die erfolgreiche Behandlung von Missed abortion bzw. intrauterinem Fruchttod mit Prostaglandin F2α in 13 Fällen berichtet. Eine Dosis von 25–100 µg/min von PGF2α führte zu regelmäßigen Uteruskontraktionen innerhalb der ersten 2 Std. Zur Eröffnung des Muttermundes kam es jedoch erst, nachdem eine Paracervicalblockade verabreicht wurde. Unerwünschte Nebeneffekte wie Übelkeit und Erbrechen konnten zwar ohne Schwierigkeiten beherrscht werden, stehen jedoch einer Routineanwendung dieser Methode noch im Wege. Weitere Untersuchungen, die im Gange sind, müssen zeigen, ob durch eine andere Applikationsart noch bessere Resultate zu erzielen sind.
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Literatur
Bergström, S., Carlson, L., Weeks, J.: The Prostaglandins, a family of biologically active lipids. Pharm. Rev.20, 1 (1968).
Blatchley, F. R., Nonivan, B. T.: Involvement of Prostaglandin F in luteolysis. Nature (Lond.)230, 243 (1971).
Bygdeman, M., Kwon, S., Wiqvist, N.: The effect of Prostaglandin E1 on human pregnant myometrium in vivo. In: Nobel symposium 2 on Prostaglandins (S. Bergström and B. Samuelsson, editors), p. 93–96. Stockholm: Almqvist and Wiksell 1967.
Csapo, A. I., Sauvage, J. P., Wiest, W. G.: The efficacy and acceptability of intravenously administered Prostaglanding F2 as an abortifacient. Amer. J. Obst. Gynec.111, 1059 (1971).
Filshie, G. M. J.: The use of Prostaglandin E2 in the management of intrauterine death, missed abortion and hydatidiform mole. Obstet. Gynec. Brit. Cwth78, 87 (1971).
Gerber, A. H., Klinger, J.: Active management of missed abortion. Obstet. Gynec.32, 312 (1968).
Karim, S. M., Sharma, S.: Therapeutic abortion and the induction of labour by the intravaginal administration of Prostaglandins E2 and F2. J. Obstet. Gynec. Brit. Cwth78, 294 (1971).
Karim, S. M., Sharma, S. D.: Intraamniotic administration of Prostaglandin. Lancet1971II, 47–48.
Karim, S. M., Filshie, G. M.: Therapeutic abortion using Prostaglandin F2. Lancet1970, 157.
Karim, S. M.: Use of Prostaglandin E2 in the management of missed abortion. Brit. med. J.1970, 196.
Martin, R., Menzies, D.: Oestrogen therapy in missed abortion and labour. J. Obstet. Gynec. Brit. Cwth62, 256 (1955).
Wiqvist, N., Bygdeman, M., Kwon, S., Mukherjee, T., Roth-Brandel, U.: The effect of Prostaglandin E1 on the midpregnant human uterus. Amer. J. Obstet. Gynec.102, 327 (1968).
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Hick, E.J., Mickan, H. & Walther, D. Kombination von Prostaglandin F2α und Paracervicalblock bei Missed Abortion und intrauterinem Fruchttod. Klin Wochenschr 51, 140–141 (1973). https://doi.org/10.1007/BF01483923
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DOI: https://doi.org/10.1007/BF01483923