Skip to main content
SpringerLink
Log in

Thyroxine and red cell 2,3-diphosphoglycerate in the newborn period

Thyroxin und 2,3-Diphosphoglycerat im Erythrocyten in der Neugeborenenperiode

  • Kurze Wissenschaftliche Mitteilungen
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

In 12 healthy newborn infants, red cell 2,3-diphosphoglycerate and plasma thyroxine levels were studied during the first 2 weeks of life. The data obtained indicate that thyroxine increases the 2,3-diphosphoglycerate concentration in the erythrocytes. Thus, thyroxine initiates via 2,3-diphosphoglycerate the accelerated decline of hemoglobin oxygen affinity taking place after birth, which facilates oxygen release from hemoglobin to the tissues.

Zusammenfassung

Bei 12 gesunden Neugeborenen wurden die 2,3-Diphosphoglycerat-Konzentration im Erythrocyten und die Thyroxinkonzentration im Plasma während der ersten 2 Lebenswochen bestimmt. Aus den erhobenen Befunden wird geschlossen, daß Thyroxin die 2,3-Diphosphoglyceratsynthese steigert. Damit leitet Thyroxin, über das 2,3-Diphosphoglycerat, die postnatal beschleunigt einsetzende Abnahme der Hämoglobin-O2-Affinität ein, womit eine erleichterte O2-Abgabe an die Gewebe verbunden ist.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bauer, Ch., Ludwig, M., Ludwig, I., Bartels, H.: Factors governing the oxygen affinity of human adult and foetal blood. Resp. Physiol.7, 271 (1969).

    Google Scholar 

  2. Benesch, R., Benesch, R. E.: The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. Biochem. biophys. Res. Commun.26, 162 (1967).

    Google Scholar 

  3. Bücher, Th., Luh, W., Pette, D.: Einfache und zusammengesetzte optische Tests mit Pyridinnucleotiden. In: Hoppe-Seyler/Thierfelder, Handbuch der physiologisch-pathologisch-chemischen Analyse, 10. Aufl., Bd. VI/A, S. 292. Berlin-Heidelberg-New York: Springer 1964.

    Google Scholar 

  4. Chanutin, A., Curnish, R. R.: Effect of organic phosphates on the oxygen equilibrium of human erythrocytes. Arch. Biochem.121, 96 (1967).

    Google Scholar 

  5. Delivora-Papadopoulos, M., Roncevic, N. P., Oski, F. A.: Postnatal changes in oxygen transport of term, premature, and sick infants: The role of red cell 2,3-diphosphoglycerate and adult hemoglobin. Pediat. Res.5, 235 (1971).

    Google Scholar 

  6. Erhard, F., Grüner, J., Marschner, I., Pickard, C. R., Scriba, P. C.: Optimierte radioimmunologische TSH-Bestimmung im Serum: Methode und Interpretation. (In preparation.)

  7. Gahlenbeck, H., Bartels, H.: Veränderungen der Sauerstoffbindungskurven des Blutes bei Hyperthyreosen und nach Gabe von Trijodthyronin bei Gesunden und bei Ratten. Klin. Wschr.46, 547 (1968).

    Google Scholar 

  8. Horn, K., Habermann, J., Henner, J., zur Horst, I., Scriba, P. C.: Automatisierte Schilddrüsenhormonanalytik im Serum: T3-in vitro-Test und Gesamtthyroxin (CPB). Z. Anal. Chem.259, 222 (1972).

    Google Scholar 

  9. Malvaux, P.: Thyroid activity during the perinatal period. Symp. Dtsch. Ges. Endokrin. 16, 91. Berlin-Heidelberg-New York: Springer 1970.

    Google Scholar 

  10. Miller, W. W., Delivoria-Papadopoulos, Miller, L. D., Oski, F. A.: Increased release of oxygen from hemoglobin in hyperthyroidism. Control by red cell 2,3-diphosphoglycerate. J. Amer. med. Ass.211, 37 (1970).

    Google Scholar 

  11. Odell, W. D., Wilber, J. F., Paul, W. E.: Radioimmunoassay of thyrotropin in human serum. J. clin. Endocr.25, 1179 (1965).

    Google Scholar 

  12. Rodriguez, J. M., Shahidi, N. T.: Erythrocyte 2,3-DPG in adaptive red-cell-volume deficiency. New Engl. J. Med.285, 479 (1971).

    Google Scholar 

  13. Schröter, W., Winter, P.: Der 2,3-Diphosphoglyceratstoffwechsel in den Erythrocyten Neugeborener und Erwachsener. Klin. Wschr.45, 255 (1967).

    Google Scholar 

  14. Snyder, L. M., Reddy, W. J.: Mechanism of action of thyroid hormones on erythrocyte 2,3-diphosphoglyceric acid synthesis. J. clin. Invest.49, 1993 (1970).

    Google Scholar 

  15. Verdier, C. H. de, Garby, L.: Low binding of 2,3-diphosphoglycerate to hemoglobin F. A contribution to the knowledge of the binding site and an explanation for the high oxygen affinity of foetal blood. Scand. J. clin. Lab. Invest.23, 149 (1969).

    Google Scholar 

  16. Versmold, H., Seiffert, G., Riegel, K. P.: Blood oxygen affinity in infancy: The interaction of fetal and adult hemoglobin, oxygen capacity, and red cell pH and 2,3-diphosphoglycerate. (In preparation.)

Download references

Author information

Authors and Affiliations

  1. Kinderklinik und II. Medizinische Klinik der Universität München, Germany

    K. Riegel, H. Versmold, H. Windthorst & K. Horn

Authors
  1. K. Riegel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Versmold
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Windthorst
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Horn
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 51 Medizinische Molekularbiologie und Biochemie.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Riegel, K., Versmold, H., Windthorst, H. et al. Thyroxine and red cell 2,3-diphosphoglycerate in the newborn period. Klin Wochenschr 51, 138–139 (1973). https://doi.org/10.1007/BF01483922

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01483922

Key words

Schlüsselwörter

Search

Navigation