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Akute Leukämie bei multiplem Myelom

Acute leukaemia in multiple myeloma

Kasuistik, Literaturübersicht, Inzidenzschätzung

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Summary

The results of a follow-up study of 112 patients with multiple myeloma are presented. Three of these patients developed acute leukaemia during the respective period of clinical observation (maximum: 11 years) — one case of acute myeloblastic leukaemia, myelomonocytic leukaemia and erythroleukaemia, myelomonocytic leukaemia and erythroleukaemia, respectively. For estimating the incidence of acute leukaemia in the presence of multiple myeloma an extended life table method was applied. On the basis of our data this method gave a probability of 5.9% for a patient to develop acute leukaemia at any time after the diagnosis of multiple myeloma. In a statistical discussion this result is considered to confirm the assumption of a highly increased AL-risk in patients with multiple myeloma. In a survey of the literature some important data of 100 cases with the association acute leukaemia — multiple myeloma are reported.

Zusammenfassung

Es werden die Ergebnisse einer Follow-up-Studie vorgelegt, in deren Rahmen insgesamt 112 Plasmozytom-Patienten maximal 11 Jahre lang unter klinischer Beobachtung standen. 3 Patienten entwickelten innerhalb des Beobachtungszeitraumes eine akute Leukämie. Hierbei handelte es sich um je einen Fall von akuter myeloblastischer Leukämie, myelomonozytärer Leukämie und Erythroleukämie. Zur Schätzung der Inzidenz von akuter Leukämie bei Ausgangsbefund Plasmozytom wird eine erweiterte Sterbetafelmethode benutzt. Aus unseren Daten erhielten wir hiermit als Wahrscheinlichkeit, daß bei einem Plasmozytompatienten irgendwann im weiteren Krankheitsverlauf eine akute Leukämie auftritt, die Zahl 5,9%. Dieses Ergebnis wird auf Grund einer ausführlichen methodischen Diskussion als Hinweis auf ein stark erhöhtes AL-Risiko bei Plasmozytom-Patienten gewertet. In einer Literaturübersicht werden wichtige Daten von 100 Fällen mit der Assoziation von Plasmozytom und akuter Leukämie zusammengestellt.

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Authors and Affiliations

  1. II. Medizinische Klinik und Poliklinik, Germany

    H. Bierbach

  2. Abteilung für Hämatologie an der I. Medizinischen Klinik und Poliklinik, Germany

    G. Zeile & J. Fischer

  3. Institut für Medizinische Statistik und Dokumentation der Universität Mainz, Germany

    S. Wellek

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  1. H. Bierbach
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  2. G. Zeile
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  3. S. Wellek
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Bierbach, H., Zeile, G., Wellek, S. et al. Akute Leukämie bei multiplem Myelom. Klin Wochenschr 57, 769–777 (1979). https://doi.org/10.1007/BF01478035

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