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Ein Beitrag zur Erklärung der Erregbarkeitssteigerung des Herzens bei Thyreotoxikose

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Summary

Investigations of thyroid hormone actions upon electrolyte exchange in body and tissues and upon electrophysiological properties of the heart, described in literature, are reviewed. Possible interactions of thyroid hormone effects upon efficiency of oxydative phosphorylation, upon electrolyte exchange and upon the excitability of the heart are discussed.

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Literatur

  1. Aebi, H., u.I. Abelin: Elektrolyt- und Fermenthaushalt der hyperthyreotischen Leber. Biochem. Z.324, 364 (1953).

    Google Scholar 

  2. Antoni, H.: Änderungen des elementaren Erregungsablaufs in flimmernden Myokardfasern. Klin. Wschr.39, 1093 (1961).

    Google Scholar 

  3. Awwad, H. K., andA. W. G. Goolden: The uptake of radioactive potassium by red cells in various thyroid states. Clin. Sci.20, 113 (1961).

    Google Scholar 

  4. Barker, S. B.: Mechanism of action of the thyroid hormone. Physiol. Rev.31, 205 (1951).

    Google Scholar 

  5. Barker, S. B.: Thyroid. Ann. Rev. Physiol.17, 417 (1955).

    Google Scholar 

  6. Barker, S. B.: Metabolic actions of thyroxine derivates and analogs. Endocrinology59, 548 (1956).

    Google Scholar 

  7. Berg, H.: Über den Herzmuskelstoffwechsel bei Hyperthyreose und seine Beeinflussung durch Vitamin C. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.185, 359 (1937).

    Google Scholar 

  8. Bing, R. J.: Metabolic activity of the intact heart. Amer. J. Med.30, 679 (1961).

    Google Scholar 

  9. Blohmke, M.: L-3,5,3′-Trijodthyronin. Dtsch. med. Wschr.35, 1432 (1957).

    Google Scholar 

  10. Boatman, J. B., J. M. Walsh, L. I. Epstein andM. J. Rabinovitz: Fluid and electrolyte changes of thyroidectomized rats in cold environment. Amer. J. Physiol.196, 1214 (1959).

    Google Scholar 

  11. Boekelman, A. J.: La glande thyroide. Régulatrice du potassium. Presse méd.56, 23 (1948).

    Google Scholar 

  12. Brewster, W. R., J. P. Isaacs, P. F. Osgood andT. L. King: The hemodynamic and metabolic interrelationsships in the activity of epinephrine, norepinephrine and the thyroid hormones. Circulation13, 1 (1956).

    Google Scholar 

  13. Brooks, C. McC., B. F. Hoffman, E. E. Suckling andO. Orias: Excitability of the heart. New York: Grune & Stratton 1955.

    Google Scholar 

  14. Byrom, F. B.: Nature of myxoedema. Clin. Sci.1 273 (1933–1934).

    Google Scholar 

  15. Cookson, H.: The thyroid and the heart. Brit. med. J.1959, 254.

  16. Coraboeuf, E.: Aspects cellulaires de l'électrogenèse cardiaque chez les vertébrés. J. Physiol. (Paris)52, 323 (1960).

    Google Scholar 

  17. McEachern, D.: Direct measurements of oxygen consumption of isolated, beating auricles from normal and thyroxic guinea pigs. Bull. Johns Hopk. Hosp.50, 287 (1932).

    Google Scholar 

  18. Fleckenstein, A., J. Janke u.E. Gerlach (unter Mitarbeit v. B. Deuticke): Konzentration und Turnover der energiereichen Phosphate des Herzens nach Studien mit Papierchromatographie und Radiophosphor. Klin. Wschr.37, 451 (1959).

    Google Scholar 

  19. Fleckenstein, A.: Enzymregulation im Herzstoffwechsel. Enzymatische Regulationen in der Klinik. Basel u. Stuttgart: Benno Schwabe & Co. 1960.

    Google Scholar 

  20. Ford, D. H., K. R. Corey andJ. Gross: The localization of thyroid hormones in the organs and tissues of the guinea pig: an autoradiographic and chromatographic study. Endocrinology61, 426 (1957).

    Google Scholar 

  21. Fox, M. E.: The mechanism of atrial fibrillation and flutter. Amer. J. Cardiol.3, 361 (1959).

    Google Scholar 

  22. Gaffney, T. E., E. Baumwald andR. L. Kahler: Effects of guanethidine on tri-iodothyronine-induced hyperthyroidism in man. New Engl. J. Med.265, 16 (1961).

    Google Scholar 

  23. Goh, K.-O., andR. D. Dallam: Oxygen consumption of the auricles, right and left ventricles of the normal, hypothyroid and hyperthyroid rat heart. Amer. J. Physiol.188, 514 (1957).

    Google Scholar 

  24. Goodford, P. J.: Metabolic factors and ventricular fibrillation. Brit. J. Pharmacol.13, 144 (1958).

    Google Scholar 

  25. Goodkind, M. J., D. H. Fram andM. Roberts: Effect of thyroid hormone on myocardial catecholamine content of the guinea pig. Amer. J. Physiol.201, 1049 (1961).

    Google Scholar 

  26. Grab, W.: Pharmakologie der Schilddrüsentätigkeit. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.216, 16 (1952).

    Google Scholar 

  27. Green, K., andA. J. Matty: Effect of thyroxine on the permeability of the isolated toad bladder. Nature (Lond.)194, 1190 (1962).

    Google Scholar 

  28. Guz, A., G. S. Kurland andA. S. Freedberg: Heart rate and O2 consumption after triiodothyronine in the myxedematous rabbit. Amer. J. Physiol.200, 58 (1961).

    Google Scholar 

  29. Hatfield, W. B., F. F. Davidoff, J. E. Ross andD. F. Tapley: The physiological disposition in the rat of the acetic and propionic acid analogues of thyroxine and triiodothyronine. Endocrinology66, 676 (1960).

    Google Scholar 

  30. Hatfield, W. B., J. E. Ross R. Herz jr. andD. F. Tapley: Physiological disposition of d- and l-triiodothyronine in rats. Amer. J. Physiol.201, 267 (1961).

    Google Scholar 

  31. Heeg, E., u.H. Lüllmann: Über den Einfluß von Thyroxin auf die Repolarisationsphase des Aktionspotentials vom Meerschweinchenvorhof. Klin. Wschr.39, 470 (1961).

    Google Scholar 

  32. Hillmann, G.: Biosynthese und Stoffwechselwirkung der Schilddrüsenhormone. In: Biochemie und Klinik, hrsg. vonG. Weitzel u.N. Zöllner. Stuttgart: Georg Thieme 1961.

    Google Scholar 

  33. Hoch, F. L., andF. Lipmann: The uncoupling of respiration and phosphorylation by thyroid hormones. Proc. nat. Acad. Sci. (Wash.)40, 909 (1954).

    Google Scholar 

  34. Hoch, F. L.: Biochemical actions of thyroid hormones. Physiol. Rev.42, 605 (1962).

    Google Scholar 

  35. Hodgkin, A. L.: The ionic basis of electrical activity in nerve and muscle. Biol. Rev.26, 339 (1951).

    Google Scholar 

  36. Holland, W. C.: Potassium exchange in atrial fibrillation. Amer. J. Physiol.190, 63 (1957).

    Google Scholar 

  37. Holland, W. C., andA. H. Briggs: Fibrillation and potassium influx. Science192, 212 (1959).

    Google Scholar 

  38. Holland, W. C., andR. L. Klein: The chemistry of heart failure. Springfield (Ill.): Ch. C. Thomas 1960.

    Google Scholar 

  39. McIntyre, M.: Effect of thyroid feeding on heart rate in normal dogs and in dogs with completely denervated hearts. Amer. J. Physiol.99, 261 (1931).

    Google Scholar 

  40. Kisch, B.: Der ultramikroskopische Bau von Herz und Capillaren. Darmstadt: Dr. Dietrich Steinkopff 1957.

    Google Scholar 

  41. Klaus, W., G. Kuschinsky u.H. Reuter: Akute Trijodthyroninwirkungen auf den Kalium-Umsatz von Meerschweinchenvorhöfen. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. (im Druck).

  42. Kleinfeld, M., E. Stein andJ. Magin: Electrical alternans in single ventricular fibers of the frog heart. Amer. J. Physiol.187, 139 (1956).

    Google Scholar 

  43. Kleinfeld, M., A. Rosenthal andE. Stein: Comparative effects of d-l-thyronine, l-triiodothyronine and l-thyroxine on the isolated perfused frog heart. Amer. J. Physiol.195, 63 (1958).

    Google Scholar 

  44. Kuschinsky, G., u.H. Lüllmann: Über die Form cellulärer Potentiale vom Rattenvorhof in Abhängigkeit von Reizfrequenz und extrasystolischer Reizung. Pflügers Arch. ges. Physiol.267, 392 (1958).

    Google Scholar 

  45. Kuschinsky, G., u.H. Reuter: Untersuchungen über eine akute Wirkung von Trijodthyronin auf Refraktärzeit und Leitungsgeschwindigkeit des Meerschweinchenvorhofs. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.242, 450 (1962).

    Google Scholar 

  46. Kuschinsky, G., u.H. Reuter: Veränderungen elektrophysiologischer Meßgrößen des Meerschweinchenherzens bei akuter Trijodthyroninwirkung. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.244, 457 (1963).

    Google Scholar 

  47. Kutzim, H.: Autoradiographische Untersuchungen über die Verteilung von Jodid, Trijodthyronin und Thyroxin bei der Maus. Z. ges. exp. Med.135, 377 (1962).

    Google Scholar 

  48. Lapland, J., O. Rougier etY.-M. Gargouil: Influence des hormones thyroidiennes sur les phénomènes de dépolarisation et de repolarisation de la fibre musculaire squelettique. C. R. Acad. Sci. (Paris)252, 334 (1961).

    Google Scholar 

  49. Larson, F. C., andE. C. Albright: Distribution of 3,5,3′-triiodothyroacetic acid in the rat. Endocrinology63, 183 (1958).

    Google Scholar 

  50. Lehninger, A. L.: Thyroxine and the swelling and contraction cycle in mitochondria. Ann. N. Y. Acad. Sci.86, 484 (1960).

    Google Scholar 

  51. Lein, A., andR. M. Dowben: Uptake and binding of thyroxine and triiodothyronine by rat diaphragm in vitro. Amer. J. Physiol.200, 1029 (1961).

    Google Scholar 

  52. Leveque, P. E.: Production of atrial fibrillation in dogs by thyroid administration and acetylcholine injection. Circulat. Res.4, 108 (1956).

    Google Scholar 

  53. Lewis, J. K., andD. McEachern: Persistance of accelerated rate in isolated hearts of thyrotoxic rabbits: response to iodides, thyroxine and epinephrine. Proc. Soc. exp. Biol. (N. Y.)28, 504 (1931).

    Google Scholar 

  54. Ling, G., andR. W. Gerard: The normal membrane potential of frog sartorius fibers. J. cell. comp. Physiol.34, 383 (1949).

    Google Scholar 

  55. Lüllmann, H.: Das Verhalten der cellulären Potentiale der Herzmuskulatur bei verschiedenen experimentellen „Insuffizienzformen“. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.237, 447 (1959).

    Google Scholar 

  56. Lüttgau, H. Ch.: Die Elektrophysiologie erregbarer Membranen. Dtsch. med. Wschr.85, 2288 (1960).

    Google Scholar 

  57. Markowitz, C., andW. M. Yater: Response of explanted cardiac muscle to thyroxine. Amer. J. Physiol.100, 162 (1932).

    Google Scholar 

  58. Marshall, J. M.: Action of iodoacetic acid, 2,4-dinitrophenol and l-triiodothyronine on the electrical response of the myocardium. Amer. J. Physiol.180, 350 (1955).

    Google Scholar 

  59. Martius, C., andB. Hess: The mode of action of thyroxin. Arch. Biochem,33, 486 (1951).

    Google Scholar 

  60. Matthes, K.: Herz und Kreislauf bei Störungen der Schilddrüsenfunktion. In: Handbuch der inneren Medizin, Bd. IX/4, S. 317. Berlin-Göttingen-Heidelberg: Springer 1960.

    Google Scholar 

  61. Mattonet, C.: Chemischer Beitrag zur Frage der Herzmuskelschädigung durch Thyroxin. Z. ges. exp. Med.90, 237 (1933).

    Google Scholar 

  62. De Mello, W. C.: Metabolism and electrical activity of the heart: action of 2-4-dinitrophenol and ATP. Amer. J. Physiol.196, 377 (1959).

    Google Scholar 

  63. Michel, R.: Thyroid. Ann. Rev. Physiol.18, 457 (1956).

    Google Scholar 

  64. Mraz, F. R., andM. Johnson: The influence of dietary sodium, potassium and desiccated thyroid upon cesium-134 metabolism in rat. Endocrinology63, 212 (1958).

    Google Scholar 

  65. Mudge, G. H.: Cellular mechanisms of potassium metabolism. Lancet1953, 166.

  66. Munro, D. S., H. Renschler andG. M. Wilson: Exchangeable potassium and sodium in hyperthyroidism and hypothyroidism. Metabolism7, 124 (1958).

    Google Scholar 

  67. Nahum, C. H., andH. E. Hoff: Auricular fibrillation in hyperthyroid patients produced by acetyl-β-methylcholine chloride, with observations on the role of the vagus and some exciting agents in the genesis of auricular fibrillation. J. Amer. med. Ass.105, 254 (1935).

    Google Scholar 

  68. Niemeyer, H., R. K. Crane, E. P. Kennedy andF. Lipmann: Observations on respiration and phosphorylation with liver mitochondria of normal, hypo- and hyperthyroid rats. Fed. Proc.10, 229 (1951).

    Google Scholar 

  69. Pitt-Rivers, R., andJ. R. Tata: The thyroid hormones. London: Pergamon Press 1959.

    Google Scholar 

  70. Pórszász, J., K. Gellén, K. Pórszász-Gibiszer andE. Kertész: Differences in Na and K content between the atrium and ventricle of the frog's heart and their dependence on metabolism. Acta physiol. (Budapest)21, 55 (1962).

    Google Scholar 

  71. Priestley, J. T., C. Markowitz andF. C. Mann: The tachycardia of experimental hyperthyroidism. Amer. J. Physiol.98, 357 (1931).

    Google Scholar 

  72. Rasmussen, H.: Influence of the thyroid hormone on the heart and circulation. Acta med. scand. Suppl.115 (1941).

  73. Scherf, D., andF. B. Chick: Abnormal cardiac rhythmus caused by acetylcholine. Circulation3, 746 (1951).

    Google Scholar 

  74. Schwartz, N. B.: Effect of dibenzyline on the metabolic actions of epinephrine and thyroxine. Amer. J. Physiol.203, 525 (1962).

    Google Scholar 

  75. Shanes, A. M.: Electrochemical aspects of physiological and pharmacological action in excitable cells. Pharmacol. Rev.10, 59 (1958).

    Google Scholar 

  76. Sjodin, R. A.: Some cation interactions in muscle. J. gen. Physiol.44, 929 (1961).

    Google Scholar 

  77. Solomon, D. H., andJ. T. Dowling: The thyroid. Ann. Rev. Physiol.22, 615 (1960).

    Google Scholar 

  78. Spang, H. K., u.C. Korth: Das Elektrokardiogramm bei Überfunktionszuständen der Schilddrüse. Arch. Kreisl.-Forsch.4, 189 (1939).

    Google Scholar 

  79. Staffurth, J. S.: Thyrotoxic myopathy. Brit. med. J.1962, 873.

  80. Surtshin, A., J. K. Cordonnier andS. Lang: Lack of influence of the sympathetic nervous system on the calorigenic response to thyroxine. Amer. J. Physiol.188, 503 (1957).

    Google Scholar 

  81. Thier, M. D., J. S. Gravenstein andR. G. Hoffmann: Thyroxine, reserpine, epinephrine and temperature on atrial rate. J. Pharmacol. exp. Ther.136, 133 (1962).

    Google Scholar 

  82. Timiras, P. S., andD. M. Woodbury: Effect of thyroid hormone on brain function and brain electrolyte distribution in rats. Endocrinology58, 181 (1956).

    Google Scholar 

  83. Trautwein, W., u.J. Dudel: Aktionspotential und Mechanogramm des Warmblüterherzmuskels als Funktion der Schlagfrequenz. Pflügers Arch. ges. Physiol.260, 24 (1954).

    Google Scholar 

  84. Trautwein, W., U. Gottstein u.J. Dudel: Der Aktionsstrom der Myokardfaser im Sauerstoffmangel. Pflügers Arch. ges. Physiol.260, 40 (1954).

    Google Scholar 

  85. Trautwein, W.: Zur Frage der spontanen Erregungsbildung im Herzen und über Faktoren, die diese beeinflussen. Verh. dtsch. Ges. inn. Med. 503 (1959).

  86. Trautwein, W.: Elektrophysiologie der Herzmuskelfaser. Ergebn. Physiol.51, 131 (1961).

    Google Scholar 

  87. Ullrick, W. C., andW. V. Whitehorn: Influence of thyroid hormone on respiration of cardiac tissue. Amer. J. Physiol.171, 407 (1952).

    Google Scholar 

  88. Vidaver, G. A.: An involvement of potassium metabolism with the effect of triiodothyronine on rat heart respiration. Arch. Biochem.90, 196 (1960).

    Google Scholar 

  89. Vitale, J. J., M. Nakamura andD. M. Hegsted: Effect of magnesium deficiency on oxidative phosphorylation. J. biol. Chem.228, 573 (1957).

    Google Scholar 

  90. Wayne, E. J.: Clinical and metabolic studies in thyroid disease. Brit. med. J.1960I, 78.

    Google Scholar 

  91. Webb, J. L., andP. B. Hollander: Metabolic aspects of the relationship between the contractility and membrane potential of the rat atrium. Circulat. Res.4, 618 (1956).

    Google Scholar 

  92. Wellby, M. L., B. S. Hetzel andB. F. Good: The circulating thyroid hormones in thyrotoxicosis. Brit. med. J.1963I, 439.

    Google Scholar 

  93. Werner, S. C.: The thyroid. London-Toronto-Melbourne-Sydney-Wellington: Cassell and Co. LTD 1955.

    Google Scholar 

  94. Whitehorn, W. V., W. C. Ullrick andB. R. Andersen: Properties of hyperthyroid rat myocardium. Circulat. Res.7, 250 (1959).

    Google Scholar 

  95. Yater, W. M.: The tachycardia time factor, survival period and seat of action of thyroxine in the perfused hearts of thyroxinized rabbits. Amer. J. Physiol.98, 338 (1931).

    Google Scholar 

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Reuter, H. Ein Beitrag zur Erklärung der Erregbarkeitssteigerung des Herzens bei Thyreotoxikose. Klin Wochenschr 41, 737–741 (1963). https://doi.org/10.1007/BF01478017

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