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Fortlaufende Registrierung der Leberdurchblutung am Menschen mit einer Wärmeleitsonde

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Zusammenfassung

1. Mit einer flexiblen, im Anschluß an eine Leberpunktion in die Leber eingeführten Wärmeleitsonde kann die lokale Leberdurchblutung des wachen Menschen fortlaufend registriert werden. Die Grundlagen dieses Verfahrens werden besprochen.

2. Die lokale Leberdurchblutung zeigt häufig spontan-rhythmische Schwankungen von durchschnittlich 20% des mittleren Durchblutungswertes. Die mittlere Periodendauer dieser Durchblutungsschwankungen beträgt 30 sec.

3. Neben den rhythmischen Schwankungen werden mitunter langsamer verlaufende Durchblutungsänderungen beobachtet, deren Periodendauern und Amplituden untereinander nicht ähnlich sind. Die Amplitude dieser Schwankungen beträgt maximal 40% der mittleren Ausgangsdurchblutung.

4. Es werden Beispiele für die Wirkung intravenöser Injektionen von Decholin, Glucose und Noradrenalin auf die lokale Leberdurchblutung angeführt. Die Durchblutungsänderungen können mitunter bei dem gleichen Stoff bei verschiedenen Patienten qualitativ verschieden ausfallen.

Summary

1. Local blood flow through the liver of unanaesthetized man has been measured by use of a special flexible „Wärmeleitsonde“ introduced into the liver by direct liver puncture. The basic features of this method are described and its validity established.

2. The local liver blood flow is not constant but shows frequent spontaneous rhythmic fluctuations of about 20% of the mean perfusion rate. The average periodicity of these fluctuations was about 30 sec.

3. In addition to these cycles there were sometimes slower, non-rhythmic variations in which in the extreme cases the blood flow could fall to 60% and rise to 140% of the initial perfusion rate.

4. Examples were given for the effects of intravenous injections of Decholine, Glucose and Noradrenaline on local liver blood flow. The same drug occasionally had qualitatively different effects on the liver blood flow in different subjects.

5. The present method by virtue of its continuous recording makes it possible to follow rapid changes in liver blood flow and thus provides information not obtainable by the usual indirect techniques. Continuous recording could be useful to obtain further information about the variations reported in measurements made by the indirect techniques.

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Authors and Affiliations

  1. Aus der Medizinischen Klinik und dem Physiologischen Institut der Universität Marburg a. d. Lahn, Germany

    Hans Erhard Bock, Klaus Graf & Herbert Hensel

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  1. Hans Erhard Bock
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  2. Klaus Graf
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  3. Herbert Hensel
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Bock, H.E., Graf, K. & Hensel, H. Fortlaufende Registrierung der Leberdurchblutung am Menschen mit einer Wärmeleitsonde. Klin Wochenschr 35, 487–493 (1957). https://doi.org/10.1007/BF01477956

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