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Comparison of indicators for dane particles

Vergleich von Tests zum Nachweis von Dane Partikeln

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Zusammenfassung

Das Dane Partikel wird als das komplette Hepatitis B Virus angesehen. Seren mit einer großen Zahl von Dane Partikeln gelten als hoch infektiös. In der vorliegenden Studie haben wir die Höhe der DNA Polymerase Aktivität — gemessen in 20fach Dane Partikel Konzentraten — mit dem HBsAg, dem HBeAg und dem anti-HBc Titer verglichen. Unsere Untersuchungen zeigen, daß der HBeAg Titer ein semiquantitatives Maß für die Zahl zirkulierender Dane Partikel darstellt. Die HBsAg Konzentration steigt ebenfalls mit der Zahl im Serum zirkulierender Dane Partikel an und stellt ebenso — wenn in HBeAg positiven Seren gemessen — ein semiquantitatives Maß für die Zahl zirkulierender Dane Partikel dar. Zwischen dem anti-HBc Titer und dem Serum Dane Partikel Gehalt besteht keine Beziehung.

Summary

The Dane particle is — because of its characteristics — believed to be the complete hepatitis-Bvirus. Sera containing high numbers of Dane particles were shown to be highly infectious. In the present study we related the HBeAg-, the HBsAg- and the anti-HBc titer to the level of DNA polymerase activity measured in 20 fold Dane particle concentrates. The data obtained indicate that the HBeAg concentration gives a semiquantitative estimate on the number of circulating Dane particles. Mean DNA polymerase activity was found to increase with HBsAg concentration and is therefore also of value-if determined in a HBeAg positive serum- for quantitation of Dane particles. The anti-HBc titer was found to be unrelated to the number of circulating Dane particles.

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Authors and Affiliations

  1. Department of Internal Medicine, Freie Universität Berlin, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19

    G. Hess, W. Arnold & K. -H. Meyer

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  1. G. Hess
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  2. W. Arnold
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  3. K. -H. Meyer
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Additional information

This study was supported by the Deutsche Forschungsgemeinschaft (He 994/2)

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Hess, G., Arnold, W. & Meyer, K.H. Comparison of indicators for dane particles. Klin Wochenschr 58, 371–376 (1980). https://doi.org/10.1007/BF01477280

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  • DOI: https://doi.org/10.1007/BF01477280

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