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Autologes131J-Humanfibrinogen zur Thrombosefrühdiagnostik

Autologous131J-tagged human fibrinogen for early detection of venous thrombosis (preparation, biological and in vivo properties)

Herstellung, biochemische Eigenschaften und Verhalten in vivo

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Summary

A method for preparation of autologous131J-tagged human fibrinogen is demonstrated.

In vitro the preparation is characterized by content of fibrinogen, protein, plasminogen, clottability and molecular weight. Total plasma radioactivity, specific radioactivity, non-protein-bound radioactivity, biologic half-life and the local activity at the thrombus define the properties in vivo.

With the above criteria autologous 131-J-tagged human fibrinogen was shown to be useful for early diagnosis of venous thrombosis.

Zusammenfassung

Es wird eine Herstellungsmethode von autologem131J-Humanfibrinogen angegeben.

Das Präparat wird charakterisiert in vitro durch Fibrinogengehalt, Proteingehalt, Plasminogengehalt, Gerinnbarkeit und Molekulargewicht der Einzelketten. In vivo werden Verlaufskurven der Gesamtplasmaaktivität, der spezifischen Aktivität, der nicht proteingebundenen Aktivität, der biologischen Halbwertszeit und des Verhaltens am Ort der Thrombose dargestellt.

An diesen Kriterien gemessen, erwies sich das autologe131J-Humanfibrinogen zur Thrombosefrühdiagnostik als voll geeignet.

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  1. Abt. Angiologie im Department Innere Medizin und Institut für Nuklearmedizin und spezielle Biophysik, Medizinische Hochschule Hannover, Germany

    Th. Wuppermann, K. Sippel & H. Dahlgrün

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  1. Th. Wuppermann
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  2. K. Sippel
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  3. H. Dahlgrün
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Wuppermann, T., Sippel, K. & Dahlgrün, H. Autologes131J-Humanfibrinogen zur Thrombosefrühdiagnostik. Klin Wochenschr 56, 437–443 (1978). https://doi.org/10.1007/BF01477057

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