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Influence of somatostatin on carbohydrate absorption in human small intestine

Einfluß von Somatostatin auf die Absorption von Kohlenhydrate im Dünndarm des Menschen

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Zusammenfassung

Bei gesunden jungen Männern wurden Kohlenhydratbelastungen mit Xylose, Galaktose und Laktose durchgeführt. 72 h später wurden die gleichen Kohlenhydratbelastungen nach zusätzlicher, intravenöser Gabe von linearem Somatostatin geprüft.

Somatostatin beeinflußt nicht die Absorption von Xylose. Galaktose-Spiegel nach oraler Gabe von Laktose und Galaktose sind unter Somatostatin jedoch deutlich vermindert. Eine Änderung der Galaktose-Spiegel nach intravenöser Galaktosezufuhr wird jedoch durch dieses Hormon nicht beobachtet. Diese Ergebnisse lassen vermuten, daß Somatostatin einen hemmenden Einfluß auf die Absorption von Monosacchariden hat.

Mögliche Einflüsse des Somatostatins auf solche Hormone, die die Absorption im Dünndarm regulieren und direkt auf Carrier-Mechanismen werden diskutiert.

Summary

Oral carbohydrate tolerance tests with xylose, galactose and lactose were performed. After an interval of at least 24 h the same tests were repeated following an i.v. bolus and during infusion of somatostatin. Somatostatin does not influence xylose absorption. However, absorption of galactose and lactose is significantly reduced (p<0.01/0.008) during somatostatin infusion. On the other hand, serum levels of galactose remain unchanged despite administration of somatostatin, when galactose is given parenterally. These results support the assumption that the absorption process in small intestine is affected by somatostatin.

Possible effects of somatostation on hormones regulating the intestinal absorption and on energy-depending carrier mechanisms are discussed.

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Authors and Affiliations

  1. Medical Clinic and Policlinic and Institute for Arteriosclerosis Research, University of Münster, Germany

    G. Pott, H. Wagner, E. Zierden, K. H. Hilke, H. Jansen, K. Hengst & U. Gerlach

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  1. G. Pott
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  2. H. Wagner
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  3. E. Zierden
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  4. K. H. Hilke
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  5. H. Jansen
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  6. K. Hengst
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  7. U. Gerlach
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Pott, G., Wagner, H., Zierden, E. et al. Influence of somatostatin on carbohydrate absorption in human small intestine. Klin Wochenschr 57, 131–133 (1979). https://doi.org/10.1007/BF01476053

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  • DOI: https://doi.org/10.1007/BF01476053

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