Skip to main content
SpringerLink
Log in

Einbau von 4-14C-markiertem Cholesterol in die Cholesterol-Ester-Fraktion der Plasma-Lipoproteine bei Lebercirrhotikern

Incorporation of 4-14C-labeled cholesterol into the cholesterol ester fractions of plasma lipoproteins in patients with cirrhosis of the liver

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

In vivo incorporation studies with 4-14C-cholesterol were performed in five patients with cirrhosis of the liver. All patients showed low concentrations of total cholesterol, esterified cholesterol, and a low activity of the lecithin: cholesterol acyltransferase activity (LCAT). The pattern of incorporation corresponded to the results known from hypercholesterolemic, normocholesterolemic and hypertriglyceridemic patients. Low cholesterol ester concentrations and low LCAT activity do not modify the pattern of incorporation into the lipoprotein ester fractions.

Zusammenfassung

Bei 5 Patienten mit gesicherter Lebercirrhose wurden in vivo-Incorporationsstudien mit 4-14-C-Cholesterol durchgeführt. Alle Patienten wiesen niedrige Gesamtcholesterol-Werte, niedrige Cholesterol-Ester-Konzentrationen und niedrige Aktivitäten für die Lecithin: Cholesterol Acyltransferase auf (LCAT). Das Inkorporationsmuster des injizierten Cholesterols entsprach dem Muster, wie es bei normocholesterinämischen, hypercholesterinämischen und hypertriglyceridämischen Patienten bekannt ist, so daß die Inkorporation offensichtlich unabhängig ist von der Esterkonzentration und der Aktivität der LCAT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Blomhoff, H.P., Skrede, S., Ritland, S.: Lecithin: cholesterol acyltransferase and plasma lipoproteins in liver disease. Clin. Chim. Acta53, 197 (1974)

    PubMed  Google Scholar 

  2. Calandra, S., Martin, M.J., McIntyre, N.: Plasma lecithin: cholesterol acyltransferase activity in liver disease. Europ. J. clin. Invest.1, 352 (1971)

    PubMed  Google Scholar 

  3. Gjone, E., Norum, K.R.: Familial serum cholesterol ester deficiency. Acta med. Scand.183, 107 (1968)

    PubMed  Google Scholar 

  4. Gjone, E., Norum, K.R.: Plasma lecithin: cholesterol acyltransferase and erythrocyte lipids in liver disease. Acta med. Scand.187, 153 (1970).

    PubMed  Google Scholar 

  5. Gjone, E., Torsvik, H., Norum, K.R.: Familial plasma cholesterol ester deficiency. A study of erythrocytes. Scand. J. clin. Lab. Invest.21, 327 (1968).

    PubMed  Google Scholar 

  6. Glomset, J.A.: The plasma lecithin: cholesterol acyltransferase reaction. J. Lipid Res.9, 155 (1968)

    PubMed  Google Scholar 

  7. Goodman, D.S.: The in vivo turnover of individual cholesterol esters in human lipoproteins. J. clin. Invest.43, 2026 (1964)

    PubMed  Google Scholar 

  8. Nestel, P.J., Couzens, E.A.: Comparison of turnover of individual cholesterol esters in subjects with low and high plasma cholesterol concentrations. J. Lab. clin. Med.66, 582 (1965)

    PubMed  Google Scholar 

  9. Norum, K.R., Gjone, E.: Familial plasma lecithin: cholesterol acyltransferase deficiency. Biochemical study of an inborn error of metabolism. Scand. J. clin. Lab. Invest.20, 231 (1967)

    Google Scholar 

  10. Osuga, T., Portman, O.W.: Origine and disappearance of plasma lecithin: cholesterol acyltransferase. Amer. J. Physiol.220, 735 (1971)

    PubMed  Google Scholar 

  11. Ritland, S., Blomhoff, J.P., Gjone, E.: Lecithin: cholesterol acyltransferase and Lipoprotein-X in liver disease. Clin. chim. Acta49, 251 (1973).

    PubMed  Google Scholar 

  12. Rose, H.G.: Influence of plasma lipoprotein levels on lipoprotein cholesterol esterification in normal and hyperlipemic subjects. Circulation46, II- 274 (1972)

    Google Scholar 

  13. Simon, J.B., Scheig, R.: Serum cholesterol esterification in liver disease. New Engl. J. Med.283, 841 (1970)

    PubMed  Google Scholar 

  14. Sodhi, H.S., Kudchodkar, B.J.: Labeling plasma lipoproteins with radioactive cholesterol. J. Lab. clin. Med.82, 111 (1973)

    PubMed  Google Scholar 

  15. Sperry, W.M., Webb, M.: A revision of the Schoenheimer-Sperry method for cholesterol determination. J. Biol. Chem.187, 97 (1950)

    PubMed  Google Scholar 

  16. Stokke, K.T., Norum, K.R.: Determination of lecithin: cholesterol acyltransferase in human plasma. Scand. J. clin. Lab. Invest.27, 21 (1971)

    PubMed  Google Scholar 

  17. Weizel, A., Weizel, H., Kinsell, L.: Cholesterol ester turnover in hyperlipidemic patients. Circulation37, VI, 25 (1968).

    Google Scholar 

  18. Wengeler, H., Greten, H., Seidel, D.: Serum cholesterol esterification in liver disease. Combined determinations of lecithin: cholesterol acyltransferase and Lipoprotein X. Europ. J. clin. Invest.2, 372 (1970)

    Google Scholar 

  19. Zilversmit, D.B.: The design and analysis of isotope experiments. Review. Amer. J. Med.29, 832 (1960)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Universitäts-Klinik Heidelberg, Germany

    A. Weizel

Authors
  1. A. Weizel
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Die Untersuchungen wurden mit Unterstützung der Deutschen Forschungsgemeinschaft durchgeführt

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weizel, A. Einbau von 4-14C-markiertem Cholesterol in die Cholesterol-Ester-Fraktion der Plasma-Lipoproteine bei Lebercirrhotikern. Klin Wochenschr 54, 739–742 (1976). https://doi.org/10.1007/BF01470466

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01470466

Key words

Schlüsselwörter

Search

Navigation