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Immunological characterization of lymphoproliferative disorders by membrane markers

Membranemarker in der Charakterisierung lymphoproliferativer Erkrankungen

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Zusammenfassung

Die Charakterisierung verschiedener Lymphozytenpopulationen mittels Oberflächenmarker hat zum immunpathologischen Verständnis der verschiedenen lymphoproliferativen Erkrankungen wesentlich beigetragen. So konnte die chronische Lymphadenose als Erkrankung der B-Lymphozyten charakterisiert werden. Bei Patienten mit Morbus Hodgkin liegt der Anteil von B- und T-Lymphozyten im peripheren Blut annähernd im Normbereich. Die vermehrte Proliferation von T-Lymphozyten könnte auf einen gesteigerten Umsatz dieser Zellen im Rahmen einer Immunantwort hindeuten. Bei Patienten mit „Non-Hodgkin“-Lymphomen konnte ein vermehrter Anteil von B-Lymphozyten in befallenen Lymphknoten gefunden werden, im peripheren Blut war diese Vermehrung allerdings selten. Veränderungen der einzelnen Lymphozytenpopulationen bei den verschiedenen Formen von „Non-Hodgkin“-Lymphomen sowie die seltenen Formen von T-Zell Lymphomen (lymphoblastolische Lymphome und Sézary-Syndrom) werden besprochen. Die Ergebnisse bei Immunozytomen und Myelomen werden im Hinblick auf die verschiedenen Reifungsstufen der B-Lymphozyten diskutiert.

Summary

The characterization of lymphocyte subpopulations by means of surface markers improved our understanding of the immunopathology of lymphoproliferative disorders. In chronic lymphocytic leukemia an accumulation of B-lymphocytes have been documented. The antibody deficiency syndrome in these patients might well reflect a maturation defect of the leukemic B-lymphocytes. In patients with Hodgkin's disease the relative number of B- and T-lymphocytes in the blood was not markedly altered in comparison to normal controls. An increased proliferation primarily of T-lymphocytes however, might suggest their accelerated turnover as an indication of the host response. In most patients with “Non-Hodgkin” lymphomas high numbers of B-lymphocytes were found in affected lymph nodes, and these appear occasionally in the peripheral blood. Differences in immunopathological manifestations of the various subgroups of the “Non-Hodgkin” lymphomas are emphasized and the rare occurrence of lymphomas of T-lymphocytes (mainly observed in lymphoblastic lymphomas and in Sézary syndrome) is discussed. Immunopathological alterations in immunocytomas and the myelomas are considered in respect to the involvement of B-lymphocytes at different stages of maturation.

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References

  1. Aisenberg, A.C., Bloch, K.J.: Immunoglobulins on the surface of neoplastic lymphocytes. New Engl. J. Med.287, 272 (1972)

    PubMed  Google Scholar 

  2. Aisenberg, A.C.: Malignant lymphoma. New. Engl. J. Med.288, 883 and 941 (1973)

    Google Scholar 

  3. Aisenberg, A.C., Long, J.C.: Lymphocyte surface characteristics in malignant lymphoma. Amer. J. Med.58, 300 (1975)

    PubMed  Google Scholar 

  4. Aiuti, F., Wigzell, H.: Function and distribution pattern of human T-lymphocytes. I. Production of anti-T lymphocyte specific sera as estimated by cytotoxicity and elimination of function of lymphocytes. Clin. exp. Immunol.13, 171 (1973)

    PubMed  Google Scholar 

  5. Asamer, H.: Zur immunzytologischen Charakterisierung immunkompetenter Lymphozyten. Wien. klin. Wschr.84, 401 (1972)

    Google Scholar 

  6. Asamer, H., Baumgartl, R., Braunsteiner, H.: Immunzytologische Untersuchungen über das Verteilungsmuster von Ig-Determinanten by Myelompatienten. Hinweise für eine klassenspezifische Restriktion auf B-Zellebene. Acta Haemat. (Basel)49, 80 (1973)

    PubMed  Google Scholar 

  7. Asamer, H.: in preparation

  8. Bianco, C., Patrick, R., Nussenzweig, V.: A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J. exp. Med.132, 702 (1970)

    PubMed  Google Scholar 

  9. Braunsteiner, H.: Plasmazellen. In: Physiologie und Pathologie der Weißen Blutzellen, ed. H. Braunsteiner, Thieme-Verlag, Stuttgart, 1959

    Google Scholar 

  10. Bremer, K., Schick, P., Wack, O., Theml, H., Brass, B., Heimpl, H.: Rezirkulation von Lymphozyten bei Patienten mit malignen lymphatischen Systemerkrankungen. Paper presented on the 15th Congr. Germ. hemat. Soc., Cologne, 1971

  11. Broome, J.D., Zucker-Franklin, D., Weiner, M.S., Bianco, C., Nussenzweig, V.: Leukemic cells with membrane properties of thymus-derived (T) lymphocytes in a case of Sezary-syndrome: morphologic and immunologic studies. Clin. Immun. Immunpathol.1, 319 (1973)

    Google Scholar 

  12. Brown, R.S., Haynes, H.A., Foley, H.T., Godwin, H.A., Berard, C.W., Carbone, P.P.: Hodgkin's disease. Immunologic, clinical and histologic features of 50 untreated patients. Ann. intern. Med.67, 291 (1967)

    PubMed  Google Scholar 

  13. Catovsky, D., Pettit, J.E., Galton, D.A.G., Spiers, A.S.D., Harrison, C.V.: Leukaemic reticuloendotheliosis (“hairy” cell leukaemia): a distinct clinico-pathological entity. Brit. J. Haemat.26, 9 (1974)

    PubMed  Google Scholar 

  14. Catovsky, D., Pettit, J.E., Galetto, J., Okos, A., Galton, D.A.G.: The B-lymphocyte nature of the hairy cell of leukaemic reticuloendotheliosis. Brit. J. Haemat.26, 19 (1974)

    Google Scholar 

  15. Cohnen, G., Douglas, S.D., König, E., Brittinger, G.: Pokeweed mitogen response of lymphocytes in chronic lymphocytic leukemia. A fine structural study. Blood42, 591 (1973)

    PubMed  Google Scholar 

  16. Cohnen, G., Augener, W., Buka, A., Brittinger, G.: Rosetteforming lymphocytes in normals and patients with malignant lymphomas. Acta haemat. (Basel)51, 65 (1974)

    PubMed  Google Scholar 

  17. Cohnen, G.: Funktion und Oberflächenmarker menschlicher T- und B-Lymphozyten. Dtsch. med. Wschr.99, 2233, (1974)

    PubMed  Google Scholar 

  18. Cohnen, G., Klinisch-diagnostische Bedeutung der Oberflächenmarker menschlicher T- und B-Lymphozyten. Dtsch. med. Wschr.99, 2302 (1974)

    PubMed  Google Scholar 

  19. Coombs, R.R.A., Feinstein, A., Wilson, A.B.: Immunoglobulin determinants on the surface of human lymphocytes. Lancetii, 1157 (1969)

    Google Scholar 

  20. Dameshek, W.: Chronic lymphocytic leukemia — an accumulative disease of immunologically incompetent lymphocytes. Blood29, 566 (1967)

    PubMed  Google Scholar 

  21. Dickler, H.B., Kunkel, H.G.: Interaction of aggregated gamma-globulin with B-lymphocytes. J. exp. Med.136, 191 (1972)

    PubMed  Google Scholar 

  22. Douglas, S.D.: Electron microscopic and functional aspects of human lymphocyte response to mitogens. Transplant. Rev.11, 39 (1972)

    PubMed  Google Scholar 

  23. Dukor, P., Bianco, C., Nussenzweig, V.: Bone marrow origin of complement receptor lymphocytes. Eur. J. Immunol.1, 491 (1971)

    PubMed  Google Scholar 

  24. Eden, A., Miller, G.W., Nussenzweig, V.: Human lymphocytes bear membrane receptors for C3b and C3d. J. clin. invest.52, 3239 (1973)

    PubMed  Google Scholar 

  25. Engeset, A., Frøland, S.S., Bremer, K.: Studies on human peripheral lymph. II. Low lymphocyte count and few B-lymphocytes in peripheral lymph of patients with chronic lymphocytic leukaemia. Scand. J. Haemat.13, 93 (1974)

    PubMed  Google Scholar 

  26. Epstein, M.A., Achong, B.G.: Various forms of Epstein-Barr virus infection in man: established facts and a general concept. Lancetii, 836 (1973)

    Google Scholar 

  27. Flad, H.D., Huber, Ch., Bremer, K., Menne, H.D., Huber, H.: Impaired recirculation of B-lymphocytes in chronic lymphocytic leukaemia. Eur. J. Immunol.3, 688 (1973)

    PubMed  Google Scholar 

  28. Flandrin, G., Brouet, J.C.: The Sézary cell: cytologic, cytochemical and immunologic studies. Mayo Clin. Proc.49, 575 (1974)

    PubMed  Google Scholar 

  29. Fink, U.: Personal communication

  30. Frøland, S.S.: Binding of sheep erythrocytes to human lymphocytes. A probable marker of T-lymphocytes. Scand. J. Immunol.1, 269 (1972)

    PubMed  Google Scholar 

  31. Galton, D.A.G.: Malignant lymphoma and Hodgkin's disease. In: “Haematology”, ed. A.V. Hoffbrand and S.M. Lewis, William Heinemann, London, 1972, p. 484ff.

    Google Scholar 

  32. Geha, R.S., Schneeberger, E., Rosen F.S., Merler, E.: Interaction of human thymus derived and non-thymus derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B-lymphocytes by a soluble factor released from antigenstimulated T-lymphocytes. J. exp. Med.138, 1230 (1973)

    PubMed  Google Scholar 

  33. Gerard-Marchant, R., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A.G., Unnik, J.A.M. van: Classification of Non-Hodgkin lymphomas. Lancetii, 406 (1974)

    Google Scholar 

  34. Goetz, O., Lampert, F., Peller, P., Prechtel, K.: Histologisch und virologisch gesicherter Burkitt-Tumor bei einem 10-jährigen Knaben. Münch. med. Wschr.112, 1373 (1970)

    Google Scholar 

  35. Greaves, M.F., Janossy, G.: Elicitation of selective T- and B-lymphocyte response by cell surface binding ligands. Trans-plant. Rev.11, 87 (1972)

    Google Scholar 

  36. Greaves, M.F., Bauminger, S.: Activation of T- and B-lymphocytes by insoluble mitogens. Nature New Biol.235, 67 (1972)

    PubMed  Google Scholar 

  37. Havemann, K., Rubin, A.D.: The delayed response of chronic lymphocytic leukemia lymphocytes to phytohemagglutinin in vitro. Proc. Soc. exp. Biol. (N.Y.)127, 668 (1968)

    Google Scholar 

  38. Havemann, K., Schmidt, M.: Lymphozytenkulturen bei Hodgkinscher Erkrankung. Hinweise für zwei Lymphozytenpopulationen bei unterschiedlicher Reaktion auf Phytohämagglutinin. Klin. Wschr.46, 31 (1968)

    PubMed  Google Scholar 

  39. Hersh, E.M., Oppenheim, J.J.: Impaired in vitro lymphocyte transformation in Hodgkin's disease. New Engl. J. Med.273, 1006 (1965)

    PubMed  Google Scholar 

  40. Huber, Ch., Huber, H., Schmalzl, F., Lederer, B., Bütterich, D., Braunsteiner, H.: DNS-synthetisierende Blutlymphozyten beim malignen Lymphogranulom. Acta haemat. (Basel)44, 222 (1970)

    PubMed  Google Scholar 

  41. Huber, Ch., Asamer, H., Wigzell, H., Braunsteiner, H.: Zur funktionellen Differenzierung lymphatischer Zellen. Lymphozyten mit Immunglobulindeterminanten und Bindungsfähigkeit für Immunkomplexe bei der Maus. Z. ges. exp. Med.156, 34 (1971)

    Google Scholar 

  42. Huber, Ch., Michlmayr, G., Huber, H.: Immunologische Marker in der Differentialdiagnose lymphatischer Systemerkrankungen. Dtsch. med. Wschr.99, 2262 (1974)

    PubMed  Google Scholar 

  43. Huber, Ch., Dworzak, E., Fink, U., Michlmayr, G., Braunsteiner, H., Huber, H.: Receptor sites for aggregated gammaglobulin (AGG) on lymphocytes in lymphoproliferative diseases. Brit. J. Haemat.27, 643 (1974)

    PubMed  Google Scholar 

  44. Huber, Ch., Kurz, R., Asamer, H., Huber, H., Braunsteiner, H.: Zur Differentialdiagnose menschlicher Blutlymphozyten mit serologischen und autoradiographischen Methoden. II. Ergebnisse bei primären und symptomatischen Immunglobulinmangelzuständen. Klin. Wschr.52, 127 (1974)

    PubMed  Google Scholar 

  45. Huber, Ch., Michlmayr, G., Falkensammer, M., Fink, U., Zur Nedden, G., Braunsteiner, H., Huber, H.: Increased proliferation of T-lymphocytes in the blood of patients with Hodgkin's disease. Clin. exp. Immun.,21, 47 (1975)

    PubMed  Google Scholar 

  46. Huber, H., Polley, M.J., Linscott, W.D., Fudenberg, H.H., Müller-Eberhard, H.J.: Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G. Science162, 1281 (1968)

    PubMed  Google Scholar 

  47. Huber, H., Fudenberg, H.H.: Receptor sites of human monocytes for IgG. Int. Arch. Allergy34, 18 (1968)

    PubMed  Google Scholar 

  48. Huber, H., Braunsteiner, H.: Pathophysiologie und Differentialdiagnose der chronischen lymphatischen Leukämie. In: Leukämie, ed. R. Gross and J. van de Loo, Springer Verlag Berlin-Heidelberg-New York, 1972, p. 415

    Google Scholar 

  49. Huber, H., Pastner, D., Gabl, F.: Laboratoriumsdiagnose hämatologischer und immunologischer Erkrankungen. Springer Verlag Berlin-Heidelberg-New York, 1972, p. 162

    Google Scholar 

  50. Huber, H., Michlmayr, G., Asamer, H., Huber, Ch., Braunsteiner, H.: Die Differenzierung menschlicher Blutlymphozyten mit immunologischen und autoradiographischen Methoden. I. Ergebnisse bei Normalpersonen und bei Patienten mit chronischer Lymphadenose. Klin. Wschr.50, 504 (1972)

    PubMed  Google Scholar 

  51. Jondal, M., Holm, G., Wigzell, H.: Surface markers of human T- and B-lymphocytes. I. A large population of lymphocytes forming non-immune rosettes with sheep red blood cells. J. exp. Med.136, 207 (1972)

    PubMed  Google Scholar 

  52. Kaplan, J., Mastrangelo, R., Peterson, W.D.: Childhood lymphoblastic lymphoma, a cancer of thymus derived lymphocytes. Cancer Res.34, 521 (1974)

    PubMed  Google Scholar 

  53. Knapp, W., Bolhuis, R.L.H., Radl, J., Hijmans, W.: Independent movement of IgG and IgM molecules on the surface of individual lymphocytes. J. Immunol.111, 1295 (1973)

    PubMed  Google Scholar 

  54. Knapp, W., Schuitt, H.R.E., Bolhuis, R.L.H., Hijmans, W.: Surface immunoglobulins in chronic lymphatic leukaemia, macroglobulinaemia and myelomatosis. Clin. exp. Immunol.16, 541 (1974)

    Google Scholar 

  55. Lay, H.L., Mendes, N.F., Bianco, C., Nussenzweig, V.: Binding of sheep red blood cells to a large population of human lymphocytes. Nature230, 531 (1971)

    PubMed  Google Scholar 

  56. Lennert, K.: Morphology and classification of malignant lymphomas and so-called reticuloses. Acta Neuropath., Supp. VI, 1 (1975)

    Google Scholar 

  57. Lennert, K.: persönliche Mitteilung

  58. Leventhal, B.G.: New looks in leukemia. National conference on childhood cancer, Dallas, May 16–18, 1974

  59. Lies, R.B., Messner, R.P., Williams, R.C.: T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus (SLE). Arthr. Rheum.15, 444 (1972)

    Google Scholar 

  60. Longmire, R.L., McMillan, R., Yelenosky, R., Armstrong, S., Long, J.E., Craddock, C.G.: In vitro splenic IgG synthesis in Hodgkin's disease. New Engl. J. Med.289, 763 (1973)

    PubMed  Google Scholar 

  61. Lukes, R.J., Collins, R.D.: New approaches to the classification of the lymphomata. Brit. J. Canc.31, Supp. 2, 1 (1975)

    Google Scholar 

  62. Mellsted, H., Hammarström, S., Holm, G.: Monoclonal lymphocyte population in human plasma cell myeloma. Clin. exp. Immun.17, 371 (1974)

    PubMed  Google Scholar 

  63. Michlmayr, G., Huber, H.: Receptor sites for complement on certain human peripheral blood lymphocytes. J. Immunol.105, 670 (1970)

    PubMed  Google Scholar 

  64. Michlmayr, G., Huber, Ch., Fink, U., Falkensammer, M., Huber, H.: T-Lymphozyten in peripheren Blut und Lymphknoten bei lymphatischen Systemerkrankungen. Schweiz. med. Wschr.104, 815 (1974)

    PubMed  Google Scholar 

  65. Michlmayr, G., Huber, Ch., Braunsteiner, H., Huber, H.: Insoluble PHA — a B-cell mitogen in man. Acta haemat. (Basel)53, 31 (1975)

    Google Scholar 

  66. Michlmayr, G., Pathouli, Ch., Huber, Ch., Huber, H.: Antibodies against T-lymphocytes in systemic lupus erythematosus. Clin. exp. Immunol.24, 18 (1976)

    PubMed  Google Scholar 

  67. Order, S.E., Porter, M., Hellmann, S.: Hodgkin's disease: evidence for a tumor associated antigen. New Engl. J. Med.285, 471 (1971)

    PubMed  Google Scholar 

  68. Papamichail, M., Brown, J.C., Holborow, E.J.: Immunoglobulins on the surface of human lymphocytes. Lancetii, 850 (1971)

    Google Scholar 

  69. Papamichail, M., Sheldon, D.J., Holborow, E.J.: T- and B-cell subpopulations in infectious mononucleosis. Clin. exp. Immun.18, 1 (1974)

    PubMed  Google Scholar 

  70. Pernis, B., Fornis, L., Amante, L.: Immunglobulin spots on the surface of rabbit lymphocytes. J. exp. Med.132, 1001 (1970)

    PubMed  Google Scholar 

  71. Pernis, B., Brouet, J.C., Seligman, M.: IgD and IgM on the membrane of lymphoid cells in macroglobulinemia. Evidence for identity of membrane IgD and IgM antibody activity in a case with anti-IgG receptors. Eur. J. Immunol.4, 776 (1974)

    PubMed  Google Scholar 

  72. Phillips, B., Roitt, I.M.: Evidence for transformation of human B-lymphocytes by PHA. Nature New Biol.241, 254 (1973)

    PubMed  Google Scholar 

  73. Pincus, S., Bianco, C., Nussenzweig, V.: Increased proportion of complement-receptor lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia. Blood40, 303 (1972)

    PubMed  Google Scholar 

  74. Preud'Homme, J.L., Seligman, M.: Anti-human IgG activity of membrane bound monoclonal immunoglobulin M in lymphoproliferative disorders. Proc. nat. Acad. Sci. (Wash.)69, 2132 (1972)

    PubMed  Google Scholar 

  75. Rappaport, H.: Tumors of the hemopoietic system. In: Atlas of Tumor Pathology, Sect. 3, Fasc. 8. Armed Forces Institute of pathology, Washington D.C.

  76. Rowe, D.S., Hug, K., Forni, L., Pernis, B.: Immunoglobulin D as a lymphocyte receptor. J. exp. Med.138, 965 (1973)

    PubMed  Google Scholar 

  77. Ross, G.D., Polley, M.J., Rabellino, E.M., Grey, H.M.: Two different complement receptors on human lymphocytes. One specific for C3b and one specific for C3b inactivator cleaved C3b. J. exp. Med.138, 798 (1973)

    PubMed  Google Scholar 

  78. Ross, G.D., Rabellino, E.M., Polley, M.J., Grey, H.M.: Combined studies on complement receptor and surface immunoglobulin bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes. J. clin. Invest.52, 377 (1973)

    PubMed  Google Scholar 

  79. Salmon, S.E., Seligman, M.: B-cell neoplasia in man. Lancetii, 1230 (1974)

    Google Scholar 

  80. Schick, P., Trepel, F., Theml, H., Benedek, S., Trumpp, P., Kaboth, W., Begemann, H., Fliedner, T.M.: Kinetics of lymphocytes in Hodgkin's disease. Blut27, 223 (1973)

    PubMed  Google Scholar 

  81. Schick, P., Trepel, F., Eder, M., Matzner, M., Benedek, S., Theml, H., Kaboth, W., Begemann, H., Fliedner, T.M.: Autotransfusion of3H-cytidine labelled blood lymphocytes in patients with Hodgkin's disease and Non-Hodkin patients. II. Exchangeable lymphocyte pools. Acta haemat. (Basel)53, 206 (1975)

    Google Scholar 

  82. Schwarz, S., Spath, P., Gabl, F., Braunsteiner, H., Huber, H.: Immunglobulin E bei chronischer lymphatischer Leukämie und monoclonalen Gammapathien. Z. Immun. Forsch.14, 196 (1974)

    Google Scholar 

  83. Schweitzer, M., Melief, C.J.M., Eijsvoogel, V.P.: The nature of the transforming lymphocyte in chronic lymphocytic leukemia. Eur. J. Immunol.3, 121 (1973)

    Google Scholar 

  84. Seligman, M., Preud'Homme, J.L., Brouet, J.C.: B and T cell markers in human lymphoproliferative diseases and primary immunodeficiencies, with special reference of membrane bound immunoglobulins. Transplant. Rev.16, 85 (1973)

    PubMed  Google Scholar 

  85. Seligman, M., Brouet, J.C.: Antibody activity of human myeloma proteins. Sem. hematol.10, 163 (1973)

    Google Scholar 

  86. Sheldon, P.J., Papamichail, M., Hemsted, E.H., Holborow, E.J.: Thymic origin of atypical lymphoid cells in infectious mononucleosis. Lanceti, 1153 (1973)

    Google Scholar 

  87. Shevach, E.M., Herbermann, R., Frank, M.M., Green, I.: Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines. J. clin. Invest.51, 1933 (1972)

    PubMed  Google Scholar 

  88. Smith, R.W., Terry, W.D., Buell, D.S., Sell, K.W.: An antigenic marker for human thymic lymphocytes. J. Immunol.110, 884 (1973)

    PubMed  Google Scholar 

  89. Stein, H., Lennert, K., Parawesch, M.R.: Malignant lymphomas of B-cell-type. Lanceti, 855 (1972)

    Google Scholar 

  90. Stein, H., Kaiserling, E., Lennert, K.: Evidence of B-cell origin of reticulum cell sarcoma. Virch. Arch. Abt. A364, 51 (1974)

    Google Scholar 

  91. Stein, H., Kaiserling, E.: Surface immunoglobulins and lymphocyte specific surface antigens on leukaemic reticuloendotheliosis cells. Clin. exp. Immunol.18, 63 (1974)

    PubMed  Google Scholar 

  92. Theml, H., Trepel, F., Schick, P., Kaboth, W., Begemann, H.: Kinetics of lymphocytes in chronic lymphocytic leukemia: studies using continous3H-thymidine infusion in two patients. Blood42, 623 (1973)

    PubMed  Google Scholar 

  93. Thomas, D.B.: Antibodies to membrane antigens common to thymocytes and a subpopulation of lymphocytes in infectious mononucleosis sera. Lanceti, 399 (1972)

    Google Scholar 

  94. Waldmann, T.A., Strober, W.: Metabolism of immunoglobulins. Progr. Allergy13, 1 (1969)

    Google Scholar 

  95. Weiner, M.S., Bianco, C., Nussenzweig, V.: Enhanced binding of neuraminidase-treated sheep erythrocytes to human T-lymphocytes. Blood42, 939 (1973)

    PubMed  Google Scholar 

  96. Wilson, J.D., Nossal, G.J.V.: Identificaton of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukemia. Lancetii, 788 (1971)

    Google Scholar 

  97. Wybran, J., Carr, M.C., Fudenberg, H.H.: The human rosetteforming cell as a marker of a population of thymus derived cells. J. clin. Invest.51, 2537 (1972)

    PubMed  Google Scholar 

  98. Wybran, J., Chantler, S., Fudenberg, H.H.: Isolation of normal T cells in chronic lymphatic leukemia. Lanceti, 126 (1973)

    Google Scholar 

  99. Yoshida, T.O., Andersson, B.: Evidence for a receptor recognising antigen complexed immunoglobulin on the surface of activated mouse thymus lymphocytes. Scand. J. Immunol.1, 401 (1972)

    PubMed  Google Scholar 

  100. Zucker-Franklin, D.: Structural features of cells associated with the paraproteinemias. Sem. Hemat.1, 165 (1964)

    Google Scholar 

  101. Concepts of B-lymphocyte activation. Transplant. Rev. 23, ed. G. Möller, Munksgaard, Copenhagen, 1975

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    H. Huber, G. Michlmayr, Ch. Huber & M. Falkensammer

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Huber, H., Michlmayr, G., Huber, C. et al. Immunological characterization of lymphoproliferative disorders by membrane markers. Klin Wochenschr 54, 699–708 (1976). https://doi.org/10.1007/BF01470461

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