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Changes of fractional renal clearance of magnesium after spironolactone administration in normal subjects

Änderung der renalen Magnesium-Clearance unter Gabe von Spironolacton bei Gesunden

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Zusammenfassung

Spironolactone wurde in Dosen von 200 mg/Tag über eine Zeitspanne von 4 Tagen an 18 klinisch Gesunde und 10 stationäre Patienten mit normaler Nierenfunktion verabreicht. Bei den Gesunden wurden Änderungen des Magnesiumanteils der renalen Clearance vor und nach der Verabreichung von Spironolacton untersucht. Bei den stationären Patienten untersuchte man entsprechende Änderungen des Verhältnisses der renalen Kalium-Clearance zur renalen Magnesium-Clearance. Nach Verabreichung von Spironolacton war die Magnesium-Clearance, verglichen mit den Werten vor der Verabreichung von Spironolacton, statistisch signifikant vermindert, während sich in bezug auf das Verhältnis

$$\frac{{Kalium - Clearance}}{{Magnesium - Clearance}}$$

keine statistisch signifikanten Änderungen zeigten.

Die Ergebnisse weisen darauf hin, daß die renale Magnesium-und Kaliumausscheidung durch die Verabreichung von Spironolacton in gleicher Weise vermindert sind.

Summary

Spironolactone, 200 mg/24 hours, was administered for 4 days to 18 clinically healthy subjects and 10 hospitalised patients with normal renal function. Changes of fractional renal clearance of magnesium before and after spironolactone administration were studied in the first group. Corresponding changes of the ratio of renal clearance of potassium to renal clearance of magnesium were studied in the second group. After spironolactone administration, fractional clearance of magnesium showed a statistically significant decrease in relation to its values before spironolactone administration, while the ratio

$$\frac{{clearance of potassium }}{{clearance of magnesium}}$$

showed no statistically significant change.

The results suggest that spironolactone administration decreases the renal excretion of magnesium and potassium in an equivalent manner.

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Authors and Affiliations

  1. 2nd Medical Department of Athens University, Greece

    Th. Mountokalakis, G. Merikas, P. Skopelitis, M. Vardakis, N. Sevastos & J. Alivisatos

  2. Department of Endocrinology of Athens Polyclinic, Greece

    Th. Mountokalakis, G. Merikas, P. Skopelitis, M. Vardakis, N. Sevastos & J. Alivisatos

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  1. Th. Mountokalakis
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  2. G. Merikas
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  3. P. Skopelitis
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  4. M. Vardakis
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  5. N. Sevastos
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  6. J. Alivisatos
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Mountokalakis, T., Merikas, G., Skopelitis, P. et al. Changes of fractional renal clearance of magnesium after spironolactone administration in normal subjects. Klin Wochenschr 53, 633–635 (1975). https://doi.org/10.1007/BF01469684

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  • DOI: https://doi.org/10.1007/BF01469684

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