Zusammenfassung
Die biliäre Rückresorption von14C-Cholsäure-Na,14C-Glycocholsäure-Na und14C-Taurocholsäure-Na nach retrograder Injektion in das Gallengangssystem der Ratte wird nachgewiesen. Bei retrograder Gabe von 20 nmol dieser Gallensalze in einem Volumen von 40 µl ist die biliäre Rückresorption signifikant erhöht im Vergleich zur Rückresorption nach retrograder Injektion dieser Gallensalze in nur 20 µl. Diese Unterschiede in der Rückresorption könnten durch eine gesteigerte Rückresorption in proximaleren Anteilen des Gallengangssystems erklärt werden.14C-Glykocholsäure-Na und14C-Taurocholsäure-Na weisen nach retrograder Injektion eine signifikant geringere Rückresorption auf als14C-Cholsäure. Es wird vermutet, daß durch die Konjugation der Cholsäure an Glycin und Taurin die biliäre Rückresorption dieser Gallensäure vermindert wird. Aufgrund der gefundenen Ergebnisse wird die Hypothese aufgestellt, daß die biliäre Rückresorption die biliäre Exkretion von Gallensalzen beeinflußt.
Summary
The results demonstrate the biliary reabsorption of14C-cholate,14C-glycocholate, and14C-taurocholate from the rat biliary tree after retrograde intrabiliary injection. It could be shown that retrograde injection of these bile salts (20 nmol) in a total volume of 40 µl leads to significantly increased biliary reabsorption in contrast to the administration in a retrograde volume of only 20 µl. These differences in reabsorption may be explained by greater reabsorption at a more proximal site in the biliary tree. Furthermore14C-glycocholate and14C-taurocholate are reabsorbed to a lesser extent in contrast to14C-cholate when bile flow was restarted at once after retrograde injection in a volume of 40 µl. It is speculated that conjugation of cholate to glycine and taurine has some effect on the extent of biliary reabsorption of this bile acid. Following the results presented in this paper one might hypothize that biliary reabsorption has an important influence on bile composition i.e. the biliary excretion of bile salts.
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Dammann, H.G. Biliary reabsorption of cholate sodium, glycocholate sodium, and taurocholate sodium from the rat biliary tree after retrograde intrabiliary injection. Klin Wochenschr 54, 845–847 (1976). https://doi.org/10.1007/BF01469307
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DOI: https://doi.org/10.1007/BF01469307