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Nierenbeteiligung bei Malaria

Renal involvement in malaria

Klinische Wochenschrift volume 54, pages 651–660 (1976)Cite this article

Summary

Malaria infection leads to renal involvement. Reversible proteinuria accompanies many plasmodial infections. Chronic malarial nephrotic syndrome is specifically associated with quartan malaria. Acute renal failure is restricted to infections with Plasmodium falciparum.

The pathogenesis of renal involvement during malarial infections includes immunological mechanisms. It is now realized that there exist at least two types of immunological processes: acute transient immune-complex glomerulonephritis with reversible proteinuria and chronic immune-complex glomerulonephritis with irreversible nephrotic syndrome.

Zusammenfassung

Malariainfektionen des Menschen können zu Störungen der Nierenfunktion führen. Eine reversible Proteinurie wird bei vielen Malariainfektionen gefunden. Das Auftreten eines nephrotischen Syndroms ist auf Malaria quartana (Erreger: Plasmodium malariae) beschränkt. Ein akutes Nierenversagen wird bei Malaria tropica (P. falciparum) beobachtet. Die pathogenetischen Mechanismen der Nierenveränderungen bei Malaria werden ausgelöst durch wenigstens zwei unterschiedliche Immunprozesse: eine akute passagere Immunkomplexglomerulonephritis mit reversibler Proteinurie und eine chronische Immunkomplexglomerulonephritis mit irreversiblem nephrotischen Syndrom.

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Authors and Affiliations

  1. Zentrum für Innere Medizin der Universität Gießen, Germany

    M. Weise

  2. Abteilung für Pädiatrische Nephrologie Medizinische Hochschule Hannover, Germany

    J. H. H. Ehrich

  3. Nuffield Institute of Comparative Medicine, The Zoological Society of London. London School of Hygiene and Tropical Medicine, UK

    A. Voller

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  1. M. Weise
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  2. J. H. H. Ehrich
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  3. A. Voller
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Weise, M., Ehrich, J.H.H. & Voller, A. Nierenbeteiligung bei Malaria. Klin Wochenschr 54, 651–660 (1976). https://doi.org/10.1007/BF01469144

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Key words

  • Malaria
  • Proteinuria
  • Nephrotic syndrome
  • Renal failure
  • Glomerulonephritis

Schlüsselwörter

  • Malaria
  • Proteinurie
  • nephrotisches Syndrom
  • Niereninsuffizienz
  • Glomerulonephritis