Zusammenfassung
37 (85%) von 44 menschlichen Mammacarcinomen konnten erfolgreich ohne zusätzlich immunsuppressive Therapie auf thymusaplastische nu/nu-Mäuse transplantiert werden. 16 Wochen nach der Transplantation zeigten 4 relativ schnell wachsende Tumoren einen menschlichen, weiblichen Chromosomensatz. Bei folgenden Untersuchungen fand sich eine gute Korrelation zwischen Originaltumor und Transplantat: Histologie, 3H-Thymidinmarkierungsindex und Androgen- bzw. Östrogenrezeptormuster.
Summary
37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estrogen.
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These studies were supported in part by the “Berta-Heilscher-Vermächtnis” and by the “Landesverband Hessen der Gesellschaft zur Bekämpfung von Krebskrankheiten”
We are indebted to Mrs. Geisler, Dr. biol., Institut für Humangenetik der Universität Frankfurt am Main, for the preparation of chromosomes
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Bastert, G., Schmidt-Matthiesen, H., Michel, R.T. et al. Human mammary cancers in nu/nu-Mice. A model for testing in research and clinic. Klin Wochenschr 55, 83–84 (1977). https://doi.org/10.1007/BF01469088
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DOI: https://doi.org/10.1007/BF01469088