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Medical treatment of gastric and duodenal ulcer

Internistische Therapie des Ulcus ventriculi und duodeni

  • Symposion On Gastric And Duodenal Ulcer Disease. Marburg 1975
  • The Surgeon's View
  • Published:
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Zusammenfassung

Antazida erweisen sich als wirksam — wenn auch nur temporär — bei der Linderung der Ulcusbeschwerden. Den Internisten ist es gelungen, die Heilungsrate beim Ulcus ventriculi durch Rauchverbot sowie durch stationäre Aufnahme und Bettruhe oder Carbenoxolontherapie beim ambulanten Patienten zu erhöhen. Die jüngsten, noch nicht endgültigen Studien mit einigen anderen Arzneimitteln zeigen zwar eine Zunahme in der Heilungsrate von Magenulzera. Es gibt aber keine internistische Therapieform, die in der Lage ist, die hohe Rezidivrate beim gutartigen Magengeschwür zu verhindern. Die spärlichen, gesicherten Daten zeigen, daß eine adäquate, medikamentöse Reduktion der Säuresekretion und eine Erhöhung der Widerstandskraft der Mucosa den Patienten mit einem Ulcus duodeni helfen könnten.

Summary

Antacids prove ready if only temporary relief of the symptoms of ulcers. Physicians have been able to increase the rate of healing of gastric ulcers by advising patients to stop smoking and then either admit them to hospital for bed-rest, or use carbenoxolone sodium as an outpatient therapy. The early trials of some other drugs have shown increase in rate of healing of gastric ulcer, but there is no medical treatment which will prevent the high recurrence rate of benign gastric ulcer. The limited data indicate that adequate medical reduction in acid secretion and enhancement of mucosal resistance may benefit patients with duodenal ulcer.

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References

  • Archambault, A., Farley, A., Gosselin, D., Martin, F.: Multicentre double-blind study of Duogastrone in the treatment of duodenal ulcers. Fourth Symposium on Carbenoxolone. Eds. F. Avery Jones & D.V. Parke, Lon. Butterworths. p. 251 (1975)

  • Bäckman, H., Kalliola, H., Ostling, G.: Placebo effect in peptic ulcer and other gastroduodenal disorders. Gastroenterologia94, 11 (1960)

    Article  PubMed  Google Scholar 

  • Banks, S., Marks, I.N.: Evolution of new drugs for peptic ulcer. Peptic Ulcer, Ed. W. Sircus. Clinics in Gastroenterology,2, No. 2. Chap. 11. p. 379. London Saunders

  • Banks, S., Marks, I.N., Palmers, P.E.S., Groll, A., Elkin, E.: A trial of carbenoxolone sodium in the treatment of gastric ulceration. S.A. med. J.41, 297 (1967)

    Google Scholar 

  • Baron, J.H.: Efficacy of medical treatment of duodenal ulcer. In Westminister Hospital Symposium on Chronic Duodenal Ulcer. Ed. C. Wastell. Chap. 12, p. 133 (1974). London, Butterworths

    Google Scholar 

  • Baron, J.H., Sullivan, F.M.: Carbenoxolone Sodium. London, Butterworths (1970)

    Google Scholar 

  • Baron, J.H., Wastell, C.: Medical Treatment. In Chronic Duodenal Ulcer. Ed. C. Wastell, Chap. 5, p. 117, London, Butterworths (1972)

    Google Scholar 

  • Bass, P.: Gastric antisecretory and antiulcer agents. Advances in Drug Research8, 205, New York, Acad. Press. (1974)

    Google Scholar 

  • Baume, P.E., Hunt, J.H.: Failure of potent antacid therapy to hasten healing in chronic gastric ulcers. Aust. Ann. Med.18, 113 (1969)

    CAS  PubMed  Google Scholar 

  • Baume, P.E., Hunt, J.H., Piper, D.W.: Glycopyrronium bromide in the treatment of chronic gastric ulcer. Gastroenterology63, 399 (1972)

    CAS  PubMed  Google Scholar 

  • Black, R.B., Rhodes, J., Davies, G.T., Gravelle, H., Sweetman, P.: A controlled clinical trial of cholestyramine in the treatment of gastric ulcer. Gastroenterology61, 821 (1971)

    CAS  PubMed  Google Scholar 

  • Boyes, B.E., Woolf, I.L., Wilson, R.Y., Cowley, D.J., Dymcock, I.W.: Treatment of gastric ulcer with a bismuth preparation. Postgrad. med. J.51, (Suppl. 5), 29 (1975)

    Google Scholar 

  • Brodgen, R.N., Speight, T.M., Avery, G.S.: Deglycyrrhizinised Liquorice: a report of its pharmacological properties and therapeutic efficacy in peptic ulcer. Drugs8, 330 (1974)

    Article  Google Scholar 

  • Butler, M.L., Gersh, H.: Antacid vs placebo in hospitalized gastric ulcer patients: a controlled therapeutic study. Amer. J. dig. Dis.20, 803 (1975)

    Article  CAS  PubMed  Google Scholar 

  • Cocking, J.B.: A trial of amylopectin sulfate (SN-263) and propantheline bromide in the long term treatment of chronic duodenal ulcer. Gastroenterology62, 6 (1972)

    CAS  PubMed  Google Scholar 

  • Cocking, J.B., McCaig, J.B.: Effect of low dosage of carbenoxolone sodium on gastric ulcer healing and acid secretion. Gut10, 219 (1969)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cooke, W.M., Baron, J.H.: Metabolic studies of deglycyrrhizinised liquorice in two patients with gastric ulcer. Digestion4, 264 (1971)

    Article  CAS  PubMed  Google Scholar 

  • Doll, R.: Medical treatment of gastric ulcer. Scot. med. J.9, 183 (1964)

    CAS  PubMed  Google Scholar 

  • Doll, R., Friedlanger, P., Pygott, F.: Dietetic treatment of peptic ulcer. Lancet1, 5 (1956a)

    Article  Google Scholar 

  • Doll, R., Price, A.V., Pygott, P., Sanderson, P.H.: Continuous intragastric milkdrip in treatment of uncomplicated gastric ulcer. Lancet1, 70 (1956b)

    Article  Google Scholar 

  • Doll, R., Jones, F.A., Pygott, F.: Effect of smoking on the production and maintenance of gastric and duodenal ulcer. Lancet1, 657 (1958)

    Article  CAS  PubMed  Google Scholar 

  • Doll, R., Hill, I.D., Hutton, C., Underwood, D.J.: Clinical trial of a Triterpenoid Liquorice Compound in Gastric and Duodenal Ulcer. LancetII, 793 (1962)

    Article  Google Scholar 

  • Doll, R., Hill, I.D., Hutton, C.F.: Treatment of Gastric Ulcer with Carbenoxolone Sodium and Oestrogen. Gut6, 19 (1965)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Doll, R., Langman, M.J.S., Shawdon, H.H.: Treatment of gastric ulcer with Carbenoxolone: antagonistic effect of spironolactone. Gut9, 42 (1968)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Doll, R., Pygott, F.: Factors influencing the rate of healing of gastric ulcers. Admissions to hospital, phenobarbitone and ascorbic acid. Lancet1, 171 (1952)

    Article  CAS  PubMed  Google Scholar 

  • Doll, R., Pygott, F.: Clinical trial of Robaden and of cabbage juice in the treatment of gastric ulcer. Lancet2, 1200 (1954)

    Article  Google Scholar 

  • Engqvist, A., Feilitzen, F., Pyk, E., Reichard, H.: Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. Gut14, 711 (1973)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Evans, P.R.C.: Value of strict dieting, drugs and robaden in peptic ulceration. Brit. med. J.1, 612 (1954)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Evans, P.R.C., Nowell, S., Thomas, I.A.P.: Blind trial of a degraded carrogeenin and aluminium hydroxide gel in the treatment of peptic ulceration. Postgrad. med. J.41, 48 (1965)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Findlay, J.M., Newaishy, G.A., Sircus, W., McManus, J.P.A.: Role of gastric irradiation in management of peptic ulceration and oesophagitis. Brit. med. J.3, 769 (1974)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fraser, P.M., Doll, R., Langman, M.J.S., Misiewicz, J.J., Shawdon, H.H.: Clinical trial of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A in the treatment of gastric ulcer. Gut13, 459 (1972)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Frommer, D.J.: The healing of gastric ulcers by zinc sulphate. Med. J. Australia2, 793 (1975)

    CAS  PubMed  Google Scholar 

  • Geismar, P., Mosbech, J., Myren, J.: A double-blind study of the effect of carbenoxolone sodium in the treatment of peptic ulcer. Scand. J. Gastroent.8, 251 (1973)

    CAS  PubMed  Google Scholar 

  • Gheorghiu, T., Frotz, H., Dole, A.: The therapeutic effect of carbenoxolone in duodenal ulcer. Preliminary analysis of a multicentre double-blind trial. Fourth Symposium on Carbenoxolone. Eds. F. Avery Jones & D.V. Parke, London, Butterworth, p. 257 (1975)

    Google Scholar 

  • Gilbert, J.A.L.: Multi-centre double-blind study of Biogastrone in the treatment of gastric ulcer. Fourth Symposium on Carbenoxolone. Eds. F. Avery Jones and D.V. Parke, London, Butterworth, p. 139 (1975)

    Google Scholar 

  • Hollander, D., Harlan, J.: Antacids vs placebos in peptic ulcer therapy. A controlled double-blind investigation. J. Amer. med. Ass.226, 1181 (1973)

    Article  CAS  Google Scholar 

  • Horwich, L., Galloway, R.: Treatment of gastric ulceration with Carbenoxolone sodium: clinical and radiological evaluation. Brit. med. J.II, 1274 (1965)

    Article  Google Scholar 

  • Hoskins, E.O.L.: Metoclopramide in benign gastric ulceration. Postgrad. med. J.49, (suppl. 4) 95 (1973)

    PubMed  Google Scholar 

  • Hunt, T., Abrams, M.E., Dykes, P., Dymcock, I.W., Hoskins, G.E., McMillan, R.B., McAndrew, G.M., Read, A.E., Watkinson, G.: Carbenoxolone in Duodenal Ulcer. Brit. J. clin. Pract.27, 140 (1973)

    Google Scholar 

  • Jones, F.A.: Gastric ulcer-aetiology and management, with special reference to Biogastrone. In Carbenoxolone in Gastroenterology, Eds. F.A. Jones and F.M. Sullivan. London, Butterworths. p. 33 (1972)

    Google Scholar 

  • Jones, F.A., Sullivan, F.M.: Carbenoxolone in Gastroenterology. London, Butterworths (1972)

    Google Scholar 

  • Jones, F.A., Parke, D.V.: Fourth Symposium on Carbenoxolone. London, Butterworths (1975)

    Google Scholar 

  • Kenwright, S., Williams, I.P., Levi, A.J., Brown, P., Williams, R.M., Read, A.E.A.: The treatment of peptic ulcer. Trial of a new non-liquorice preparation-Zolimidine. Clin. Trials. J.2, 51 (1974)

    Google Scholar 

  • Langman, M.J.S., Knapp, D.R., Wakely, E.J.: Treatment of chronic gastric ulcer with Carbenoxolone and gefarnate: a comparative trial. Brit. med. J.3, 84 (1973)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lawrence, J.S.: Dietetic and other methods in the treatment of peptic ulcer. Lancet1, 482–485 (1952)

    Article  CAS  PubMed  Google Scholar 

  • Levin, E.: The relationship of continuous acid secretion and intermittent acid secretion to the formation of recurring duodenal ulcer (A controlled study). In Modern Gastroenterology, Proceedings VIIIth International Congress of Gastroenterology, Prague, 1968, Eds. O. Gregor & O. Riedl. Stuttgart: Schattauer-Verlag. p. 112 (1969)

    Google Scholar 

  • Middleton, W.R.J., Cooke, A.R., Stephen, D., Skyring, A.P.: Biogastrone in inpatient treatment of gastric ulcer. Lancet1, 1030 (1965)

    Article  CAS  PubMed  Google Scholar 

  • Moshal, M.G.: A double-blind gastroscopic study of a bismuthpeptide complex in gastric ulceration. S. Afr. med. J.48, 1610 (1974)

    CAS  PubMed  Google Scholar 

  • Moshal, M.G.: The treatment of duodenal ulcers with TDB: a duodenoscopic double-blind cross-over investigation. Postgrad. med. J.51, suppl. 5, p. 36 (1975)

    PubMed  Google Scholar 

  • Newcomb, P.B., Stone, W.D., Richardson, D.C.: A double-blind clinical trial of geranyl farnesyl acetate against placebo in the treatment of gastric ulcer. Abstr, 4th World Congress Gastroenterology, Copenhagen, p. 313 (1970)

  • Ottenjann, R., Rosch, W.: Clinical and experimental studies on Carbenoxolone sodium. in Carbenoxolone Sodium. Eds. J.H. Baron & F.M. Sullivan. London, Butterworths, p. 75 (1970)

    Google Scholar 

  • Palmer, W.L.: Gastric irradiation in peptic ulcer. Chicago, University Press (1974)

    Google Scholar 

  • Piper, D.W.: Antacid and anticholinergic drug therapy. In: Peptic Ulcer, Ed. W. Sircus. Clinics in Gastrenterology, 2, No. 2, Chap. 10, p. 361. London, Saunders (1973)

    Google Scholar 

  • Piper, D.W., Heap, T.R.: Medical Management of Peptic Ulcer with reference to anti-ulcer agents in other gastrointestinal diseases. Drugs3, 366 (1972)

    Article  CAS  PubMed  Google Scholar 

  • Robson, J.M., Sullivan, F.M.: A Symposium on Carbenoxolone Sodium. London, Butterworths, 1968

    Google Scholar 

  • Russell, R.I., Dickie, J.E.N.: Clinical trial of a degylcyrrhizinised liquorice preparation in peptic ulcer. J. Therap. Clin. Research2, 2 (1968)

    Google Scholar 

  • Salmon, P.R., Brown, P., Williams, R., Read, A.E.: Evaluation of colloidal bismuth (De-Nol) in the treatment of duodenal ulcer employing endoscopic selection and follow up. Gut15, 189 (1974)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sarles, H., Camatte, R., Gauthier, A.P., Bouillon, M.: Étude controlée de l'action des traitements “d'entretien” entre les poussées de la maladie ulcéreuse duodénale. Arch. Mal. Appar. dig.61, 735 (1972)

    CAS  Google Scholar 

  • Scobie, B.A.: Gastric ulcer treatment with carbenoxolone sodium. (‘Biogastrone’). N.Z. med. J.65, 308 (1966)

    CAS  PubMed  Google Scholar 

  • Siurala, M., Varis, K., Gorbatow, O., Kause, P., Laulajainew, M., Nyberg, L.O.: The effect of oestriol succinate upon healing of duodenal ulcer: a controlled study. Scand. J. Gastroent.45, 469 (1969)

    Article  Google Scholar 

  • Shreeve, D.R.: A double-blind study of tri-potassium di-citrato bismuth in duodenal ulcer. Postgrad. med. J.51, (Suppl. 5), 33 (1975)

    CAS  PubMed  Google Scholar 

  • Sircus, W.: Carbenoxolone sodium. Gut13, 816 (1972)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stolte, J.B.: A therapeutic experiment on peptic ulcer. Lancet2, 858 (1950)

    Article  CAS  PubMed  Google Scholar 

  • Sun, D.C.H.: A controlled trial of antacid, propantheline and amylopectin sulphate in duodenal ulcer. Amer. J. Gastroent.60, 449 (1974)

    Google Scholar 

  • Sun, D.C.H., Ryan, M.L.: A controlled study on the use of propantheline and amylopectin sulfate (SN-263) for recurrences in duodenal ulcer. Gastroenterology58, 756 (1970)

    CAS  PubMed  Google Scholar 

  • Tewari, S.N., Trembalowicz, F.C.: Some experience with deglycyrrhizinated liquorice in the treatment of gastric and duodenal ulcers with special references to its spasmolytic effect. Gut9, 48 (1968)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Truelove, S.C.: Stilboestrol, phenobarbitone and diet in chronic duodenal ulcer. A factorial therapeutic trial. Brit. med. J.2, 559 (1960)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Turpie, A.G.G., Thomson, T.J.: Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side effects. Gut6, 591 (1965)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Turpie, A.G.G., Runcie, J., Thomson, T.J.: Clinical trial of deglycyrrhizinized liquorice in gastric ulcer. Gut10, 299 (1969)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walan, A.: Studies in peptic ulcer disease with special reference to the effect of 1-hyposcyamine. Acta. med. scand., Suppl. 516 (1970)

  • Van-Camp, F., Standaert, L.: Vergelijkende studie in de behandeling van het maagulcus met Cabenoxolone. T. Gastro-ent.17, 51 (1974)

    Google Scholar 

  • Zimmon, D.S., Miller, G., Cox, G., Tesler, M.A.: Specific inhibition of gastric pepsin in the treatment of gastric ulcer. Gastroenterology.56, 19 (1969)

    CAS  PubMed  Google Scholar 

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  1. Department of Surgery, Royal Postgraduate Medical School Hammersmith Hospital, London

    J. H. Baron

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Baron, J.H. Medical treatment of gastric and duodenal ulcer. Klin Wochenschr 54, 915–925 (1976). https://doi.org/10.1007/BF01469005

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  • DOI: https://doi.org/10.1007/BF01469005

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