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Die Wirkung von Indomethacin auf die basale und stimulierte Plasmareninaktivität beim Menschen

The effect of indomethacin on basal and stimulated plasma renin activity in normal subjects

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Summary

The influence of indomethacin, a potent inhibitor of prostaglandin synthesis, on basal and stimulated plasma renin activities in normal human subjects was determined. Stimulation of the renin activity was achieved by orthostasis or by furosemide. Indomethacin led to a considerable decrease of both basal and stimulated plasma renin activity in chronic and acute experiments. Our experiments provide no evidence that major changes in the sodium balance are responsible for the effects observed. It is concluded that some antagonistic function of the renin angiotensin system and prostaglandins seems probable. These antagonistic actions might play a role in the regulation of the kidney circulation or the arterial blood pressure.

Zusammenfassung

Es wurde der Einfluß des Hemmstoffes der Prostaglandinsynthese Indomethacin auf die basale und stimulierte Plasmareninaktivität bei gesunden Versuchspersonen untersucht. Die Stimulation der Reninaktivität wurde durch Orthostase beziehungsweise durch Furosemid erzielt. Indomethacin führte bei chronischer und bei einmaliger Medikation zu einer deutlichen Senkung sowohl der basalen als auch der stimulierten Plasmareninaktivität. Eine wesentliche Natriumretention scheint als Mechanismus der Senkung der Reninaktivität durch Indomethacin nicht wahrscheinlich. Es werden antagonistische Funktionen von Renin-Angiotensin-System und Prostaglandinen für möglich gehalten, die bei der Regulation der Nierendurchblutung oder der Blutdruckregulation eine Rolle spielen könnten.

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Authors and Affiliations

  1. Nephrologische Abteilung, Medizinische Universitätsklinik und Poliklinik Göttingen, Germany

    K. W. Rumpf, S. Frenzel, H. D. Lowitz & F. Scheler

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  1. K. W. Rumpf
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  2. S. Frenzel
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  3. H. D. Lowitz
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  4. F. Scheler
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Mit Unterstützung durch den SFB-89-Kardiologie der Deutschen Forschungsgemeinschaft.

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Rumpf, K.W., Frenzel, S., Lowitz, H.D. et al. Die Wirkung von Indomethacin auf die basale und stimulierte Plasmareninaktivität beim Menschen. Klin Wochenschr 54, 255–259 (1976). https://doi.org/10.1007/BF01468920

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  • DOI: https://doi.org/10.1007/BF01468920

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