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Present status of32P-therapy in management of polycythemia vera

Gegenwärtiger Stand der32P-Therapie bei Polycythaemia Vera

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Zusammenfassung

Das Ziel der Studie war eine Standortbestimmung der32P-Therapie bei der Polycythaemia vera. Hierzu wurde die Natur der Erkrankung und die damit verbundenen klinischen Probleme zur Wirkungs-Charakteristik der verschiedenen Therapie-Möglichkeiten in Beziehung gesetzt. Wir kamen zu dem Schluß, daß32P vorzugsweise bei älteren Patienten eingesetzt werden sollte, insbesondere wenn Langzeit-Remissionen erzielt werden können; außerdem bei Patienten die keine Gewähr für eine zuverlässige Medikamenten-Einnahme bieten, oder solchen, die nicht regelmäßig überwacht werden können. Günstige Anwendungsbereiche der Chemotherapie sind jüngere Patienten. Fälle, die ungenügend auf32P reagieren, insbesondere wenn die Proliferationsaktivität der Granulocytopoese stark dominiert, oder wenn die Intervalle zwischen der erforderlichen32P-Applikation unter einem Jahr liegen.

Summary

The aim of this study is to assess the present status of32P-therapy in the management of polycythemia vera. The nature of the disease and its associated clinical problems was considered with respect to the characteristics of the different therapeutic approaches. We concluded that32P is preferably administered to older patients, especially if long term remissions are achieved, if drugs are taken unreliably, or if patients are difficult to supervise. At present chemotherapy is preferably administered to younger patients, to those who respond inadequately to32P, or who demonstrate early relapsing hyperproliferation of granulocytopoiesis, or who require32P-administration at intervals shorter than one year.

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References

  1. Burkhardt, R.: Knochenmark-Histologie und Klinik der polycythaemia vera. Arch. Klin. Med.216, 64 (1969)

    PubMed  Google Scholar 

  2. Calabresi, P., Meyer, O.O.: Polycythemia vera. II. Course and therapy. Ann. intern. Med.50, 1203 (1959).

    PubMed  Google Scholar 

  3. Dameshek, W.: The case for phlebotomy in polycythemia vera. Blood32, 488 (1968)

    PubMed  Google Scholar 

  4. Halnan, K.E., Russell, M.H.: Polycythemia vera. Comparison of survival and causes of death in patients managed with and without radiotherapy. Lancet1965 II, 760

    Google Scholar 

  5. Harman, J.B., Ledlie, E.M.: Survival of polycythemia vera patients treated with radioactive phosphorus. Brit. med. J.1967 II, 146

    Google Scholar 

  6. Hunstein, W., Hauswaldt, Ch.: Die Osteomyelofibrose. Klin. Wschr.52, 305 (1974)

    PubMed  Google Scholar 

  7. Klein, H., Jacobson, L.O.: Management of polycythemias. In: Klein, H. (ed.), Polycythemia vera. Theory and management, p. 209. Springfield, Illinois, U.S.A.: Charles C Thomas, Publisher 1973

    Google Scholar 

  8. Kyle, R.A., Schwartz, R.S., Oliner, H.L., Dameshek, W.: A syndrome resembling adrenal cortical insufficiency associated with long term busulphan (myeleran) therapy.

  9. Lawrence, J.H.: Nuclear physics and therapy: preliminary report on a new method for the treatment of leukemia and polycythemia. Radiology35, 51 (1940).

    Google Scholar 

  10. Lawrence, J.H.: Polycythemia, physiology, diagnosis and treatment based on 303 cases. New York and London: Grune & Stratton 1955

    Google Scholar 

  11. Lawrence, J.H., Berlin, N.I., Huff, R.L.: The nature and treatment of polycythemia. Medicine (Baltimore)32, 323 (1953).

    PubMed  Google Scholar 

  12. Lawrence, J.H., Winchell, H.S., Donald, W.G.: Leukemia in Polycythemia vera. Relationship to splenic myeloid metaplasia and therapeutic radiation dose. Ann. intern. Med.70, 763 (1969)

    PubMed  Google Scholar 

  13. Ledlie, E.M.: The incidence of leukemia in patients with polycythemia vera treated by radioactive phosphorus. Clin. Radiol.11, 130 (1960)

    PubMed  Google Scholar 

  14. Meuret, G., Hoffmann, G.: Pathogenese und Manifestation von Störungen der Erythro- und Granulopoese bei myeloproliferativen Syndromen. Klin. Wschr.50, 853 (1972).

    PubMed  Google Scholar 

  15. Meuret, G., Hoffmann, G., Gmelin, R.:32P-therapy in polycythemia vera. Klin. Wschr. (to be published)

  16. Modan, B.: The polycythemic disorders. Springfield, Illinois: Charles C Thomas, Publisher 1971

    Google Scholar 

  17. Modan, B., Lilienfeld, A.M.: Polycythemia vera and leukemia. The role of radiation treatment. Medicine (Baltimore)44, 305 (1965).

    PubMed  Google Scholar 

  18. Osgood, D.: Polycythemia vera. Age relationship and survival. Blood26, 243 (1965).

    PubMed  Google Scholar 

  19. Perkins, J., Israels, M.C.G., Wilkinson, J.F.: Polycythaemia vera: clinical studies on a series of 127 patients managed without radiation therapy. Quart. J. Med.33, 499 (1964)

    PubMed  Google Scholar 

  20. Reinhard, E.H., Hahnemann, B.: The treatment of polycythemia vera. J. chron. Dis.6, 332 (1957)

    PubMed  Google Scholar 

  21. Senn, H.J.: Infektabwehr bei Hämoblastosen. Experimentelle Medizin, Pathologie und Klinik, vol. 36. Berlin-Heidelberg-New York: Springer 1972

    Google Scholar 

  22. Stecher, G., Wolfers, H., Nettesheim, P.: Polycythemia vera. Dtsch. med. Wschr.86, 1899 (1961)

    PubMed  Google Scholar 

  23. Tubiana, M., Flamant, R., Attie, E., Hayat, M.: A study of hematological complications occurring in patients with polycythemia vera treated by 32P. Blood32, 536 (1968)

    PubMed  Google Scholar 

  24. Tubiana, M., Loiseau, J.P., Vallée, G.: L'évolution des polyglobulies essentielles. Intérêt des épreuves successives par le chrome et le fer radioactives. Nouv. Rev. franç. Hémat.5, 397 (1965)

    Google Scholar 

  25. Videbaek, A.: Polychthemia vera. Course and prognosis. Acta med. scand.138, 179 (1950)

    PubMed  Google Scholar 

  26. Wasserman, L.R.: Polycythemia vera — its course and treatment: relation to myeloid metaplasia and leukemia. Bull. N.Y. Acad. Med.30, 343 (1954)

    PubMed  Google Scholar 

  27. Wasserman, L.R., Gilbert, H.S.: The treatment of polycythemia vera. Med. Clin. N. Amer.50, 1501 (1966)

    PubMed  Google Scholar 

  28. Wasserman, L.R.: Epiloque. In: Klein, H. (ed.), Polycythemia. Theory and management, p. 238. Springfield, Illinois, U.S.A.: Charles C Thomas, Publisher 1973

    Google Scholar 

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  1. Department of Hematology and Oncology, Kantonsspitel, St. Gallen, Switzerland

    G. Meuret

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Meuret, G. Present status of32P-therapy in management of polycythemia vera. Klin Wochenschr 53, 555–558 (1975). https://doi.org/10.1007/BF01468899

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