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Verhalten der Reninaktivität im Plasma während des menstruellen Cyclus und in der Postmenopause

Pattern of renin activity in plasma during the menstrual cycle and in postmenopausal women

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Summary

Plasma renin activity (PRA) was continuously estimated under controlled conditions in seven women with ovulatory cycle, in six women with anovulatory cycle and in ten postmenopausal women. Blood samples were taken after at least 6 hours of sleep before getting up, between 7.30 and 9.30 a.m. in the young women and between 6.00 and 7.00 a.m. in the postmenopausal women. PRA was measured by radioimmunological determination of angiotensin I which was liberated during incubation under defined conditions. In women with ovulatory cycle, PRA generally increased before ovulation; following a transient decrease, PRA increased again during the luteal phase. Shortly before or at the beginning of menstrual bleeding, an additional but small peak of PRA was observed in some subjects. PRA remained relatively low in women with anovulatory cycle during their follicular phase; during the second half of the cycle, a tendency towards higher values was observed. In postmenopausal women, PRA was constantly low. The results presented here strongly suggest that an interpendence exists between the renin-angiotensin system and female sex hormones. Various possibilities are discussed for explaining the mode of these interactions.

Zusammenfassung

Die Plasmareninaktivität (PRA) wurde unter kontrollierten Bedingungen kontinuierlich bei sieben Frauen mit ovulatorischem Cyclus, bei sechs Frauen mit sicher oder fraglich anovulatorischem Cyclus und bei zehn Frauen in der Postmenopause bestimmt. Die Blutentnahmen erfolgten nach mindestens sechsstündigem Schlaf vor dem Aufstehen, und zwar zwischen 7.30 und 9.30 Uhr bei den jungen Versuchspersonen und zwischen 6.00 und 7.00 Uhr bei den Frauen in der Postmenopause. Die PRA wurde durch radioimmunologische Bestimmung von Angiotensin I, das während einer Inkubation unter definierten Bedingungen freigesetzt wurde, ermittelt. Bei Frauen mit ovulatorischem Cyclus stieg die PRA im allgemeinen präovulatorisch an; nach einem vorübergehenden Abfall nahm die PRA in der Lutealphase wiede4r zu. Manchmal wurde kurz vor oder zu Beginn der Menstruation ein erneuter, kurzdauernder Anstieg der PRA beobachtet. Bei Frauen mit anovulatorischem Cyclus blieb die PRA während der Follikelphase relativ niedrig; in der zweiten Cyclushälfte war eine Tendenz zu höheren Werten erkennbar. Bei Frauen in der Postmenopause war die PRA gleichbleibend niedrig. Die vorgelegten Befunde sprechen für eine Abhängigkeit des Renin-Angiotensin-Systems von den weiblichen Sexualhormonen. Es werden mehrere Möglichkeiten zur Erklärung dieser Zusammenhänge diskutiert.

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Authors and Affiliations

  1. Institut für Klinische Biochemie und Klinische Chemie der Universität Bonn, Germany

    H. Kaulhausen, W. Oehm & H. Breuer

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  1. H. Kaulhausen
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  2. W. Oehm
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  3. H. Breuer
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Additional information

Auszugsweise vorgetragen von H. Kaulhausen auf dem 19. Symposium der Deutschen Gesellschaft für Endokrinologie, Berlin, 28.2–3.3.1973 [1].

Teil der Dissertation W. Oehm, Medizinische Fakultät der Universität Bonn.

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Kaulhausen, H., Oehm, W. & Breuer, H. Verhalten der Reninaktivität im Plasma während des menstruellen Cyclus und in der Postmenopause. Klin Wochenschr 52, 33–38 (1974). https://doi.org/10.1007/BF01468520

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