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Zur Entstehung cytoplasmatischer Vakuolen von Leukocyten im in-vitro-Versuch

On the formation of cytoplasmic vacuoles of leukocytes in vitro. I. formation of cytoplasmic vacuoles in dependence on inflammatory processes

I. Bildung cytoplasmatischer vakuolen in abhängigkeit von Entzündungsprozessen

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Summary

The formation of cytoplasmic vacuoles of neutrophilic granulocytes and monocytes after ingestion of latex particles dependent on inflammations of different etiology had been studied in vitro. The ingestion of latex particles as well as the formation of cytoplasmic vacuoles is increased by acute inflammations. As to neutrophilic granulocytes it could be shown that this increase is caused not only by an enhancement of the capacity of ingestion and the formation of vacuoles of the single cell but also by an increase in the cell percentage being involved in both reactions. The present study suggests that inflammatory processes stimulate ingestion and, secondarily, the formation of vacuoles.

Apart from the increase in the total leukocyte count and the change of distribution of the different kinds of leukocytes in the peripheral blood the increase in the ingestion capacity and the vacuoles formation represents a reaction in acute inflammation.

Zusammenfassung

In vitro wurde die Bildung cytoplasmatischer Vakuolen von neutrophilen Granulocyten und Monocyten nach Ingestion von Latexpartikeln in Abhängigkeit von Entzündungen verschiedener Ätiologie untersucht. Durch akute Entzündungen wird die Ingestion von Latex-partikeln und die Bildung cytoplasmatischer Vakuolen beider Leukocytenarten gesteigert. Für neutrophile Granulocyten wurde gezeigt, daß diese Steigerung sowohl durch eine Zunahme der Kapazität der Ingestion und der Vakuolenbildung der Einzelzelle als auch durch eine prozentuale Zunahme der an beiden Vorgängen beteiligten Zellen bedingt ist. Durch die Untersuchungen wird der Hinweis gegeben, daß Entzündungen die Ingestion und sekundär die Vakuolenbildung stimulieren.

Neben der Zunahme der Gesamtleukocytenzahl und der Änderung der Verteilung der Leukocytenarten im peripheren Blut ist die Steigerung der Ingestion und Vakuolenbildung eine Reaktion der Leukocyten während akuter Entzündungen.

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Authors and Affiliations

  1. Universitäts-Kinderklinik Marburg a.d.Lahn, Germany

    G. Seebach & C. Eschenbach

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  1. G. Seebach
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  2. C. Eschenbach
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Herrn Prof. Dr. med. F. Linneweh zum 65. Geburtstag gewidmet.

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Seebach, G., Eschenbach, C. Zur Entstehung cytoplasmatischer Vakuolen von Leukocyten im in-vitro-Versuch. Klin Wochenschr 52, 678–687 (1974). https://doi.org/10.1007/BF01468479

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