Summary
Isolated membranes (ghosts) of human erythrocytes of newborn infants produce Heinz bodies faster after an exposure to acetylphenylhydrazine than the ghosts of adults. Heinz bodies form faster in ghosts prepared from erythrocytes of newborn infants, incubated in their own plasma or in the plasma of adults, than in ghosts of incubated red cells of adults. A direct relation can be seen between the hemoglobin content of the ghosts and the formation of Heinz bodies. It is suggested that the Heinz body susceptibility of normal human erythrocytes depends on the quantity of hemoglobin bound to the red cell membrane.
Zusammenfassung
Isolierte Membranen (Ghosts) von Neugeborenenerythrocyten bilden in Gegenwart von Acetylphenylhydrazin schneller Heinzkörper als Ghosts von Erwachsenenerythrocyten. Auch aus Neugeborenenerythrocyten, die im eigenen Plasma oder im Plasma Erwachsener inkubiert wurden, gewonnene Ghosts bilden schneller Heinzkörper als Ghosts, die aus inkubierten Erwachsenenerythrocyten gewonnen wurden. Der Hämoglobingehalt der Ghosts korreliert mit ihrer Heinzkörperempfindlichkeit. Es wird angenommen, daß die Heinzkörperempfindlichkeit normaler Erythrocyten von der Menge des an die Membran gebundenen Hämoglobinanteils abhängt.
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This work was supported by the Deutsche Forschungsgemeinschaft, Bad Godesberg, Grants No. Schr 86/8 and Schr 86/9.
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Tillmann, W., Menke, J. & Schröter, W. The formation of heinz bodies in ghosts of human erythrocytes of adults and newborn infants. Klin Wochenschr 51, 201–203 (1973). https://doi.org/10.1007/BF01468345
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DOI: https://doi.org/10.1007/BF01468345