Summary
36 healthy subjects were constantly infused for 6 hours with fructose, sorbitol and xylitol at 0.125 to 0.5 g/kg/h body weight. Serum triglycerides did not change significantly. Xylitol and fructose had no effect on cholesterol concentration. However, sorbitol caused a significant decrease in cholesterol levels.
Zusammenfassung
36 gesunde Männer erhielten eine sechsstündige Dauerinfusion von Fruktose, Sorbit und Xylit in einer Dosis von 0,125 bis 0,5 g/kg/h. Die Serumtriglyzeride zeigten keine Veränderungen. Xylit und Fruktose blieb auf die Cholesterinkonzentrationen ohne Effekt, während die Zufuhr von Sorbit zu einer signifikanten Senkung des Cholesterins führte.
Literatur
Anderson, J. T., Grand, F., Matsumoto, Y., Keys, A.: Glucose, sucrose and lactose in the diet and blood lipids in man. J. Nutr.79, 349 (1963)
Antonis, A., Bersohm, J.: The influence of diet on serum triglycerides in South African white and Bantu prisoners. Lancet1961 I, 3
Antar, M.A., Ohlson, M.A.: Effect of simple and complex carbohydrates upon total lipids, nonphospholipids, and different fractions of phospholipids of serum in young men und women. J. Nutr.85, 329 (1965)
Bässler, K.H., Stein, G.: Biochemische Grundlagen für Wirkungsunterschiede zwischen Sorbit und Fructose. Hoppe-Seylers Z. physiol. Chem.348, 533 (1967)
Bragdon, J.H., Gordon, R.S.: Effects of carbohydrate feeding on serum lipids and lipoproteins in the rat. Amer. J. Physiol.189, 63 (1957)
Farguhar, J.W., Frank, A., Gross, R.C., Reaven, G.M.: Glucose, Insulin and triglyceride responses to high and low carbohydrate diets in man. J. clin. Invest.45, 1648 (1966)
Grant, W.C., Fahrenbach, M.J.: Effect of dietary succrose and glucose on plasma cholesterol in chicks and rabbits. Proc. Soc. exp. Biol. (N.Y.)100, 250 (1959)
Guggenheim, K., Ilan, J., Peretz, E.: Effect of dietary carbohydrates and aureomycin on serum and liver cholesterol in rats. J. Nutr.72, 93 (1960)
Hatch, F.T., Abell, L.L., Kendall, F.E.: Effects of restriction of dietary fat and cholesterol upon serum lipids and lipoproteins in patients with hypertension. Amer. J. Med.19, 48 (1955)
Jourdan, M.H., MacDonald, I., Henderson, J.R.: The effects of14C-Xylitol, given intravenously on the serumglucose, insulin and lipid concentrations of male and female baboons. Nutr. Metabol.14, 92 (1972)
Kaufmann, N. A., Poznanski, R., Blondheim, S. H., Stein, Y.: Changes in serum lipid levels of hyperlipemic patients following the feeding of starch, sucrose and glucose. Amer. J. clin. Nutr.18, 261 (1966)
Keys, A., Anderson, J.T., Grande, F.: Diet-type (fats constant) and blood lipids in man. J. Nutr.70, 257 (1960)
Kritchevsky, D., Kolman, R. R., Guttmacher, R. M., Forbes, M.: Influence of dietary carbohydrate and protein on serum and liver cholesterol in germfree chickens. Arch. Biochem. Biophys.85, 444 (1959)
Kritchevsky, D., Sallata, P., Tepper, S.A.: Experimental atherosclerosis in rabbits fed cholesterol-free diets. Part 2: Influence of various carbohydrates. J. Atheroscler. Res.8, 697 (1968)
MacDonald, T., Braithwaite, D.M.: The influence of dietary carbohydrates on the lipid patterns in serum and adipose tissue. Clin. Sci.27, 23 (1964)
MacDonald, J., Roberts, J. B.: The incorporation of various14C dietary carbohydrates into serum and liver lipids. Metabolism14, 991 (1965)
MacDonald, T.: Effects of dietary glycerol on the serum glyceride level of men and women. Brit. J. Nutr.24, 537 (1970)
MacGandy, R.B., Hegsted, D.M., Myers, M.L., Stare, F.J.: Dietary carbohydrate and serum cholesterol level in man. Amer. J. clin. Nutr.18, 237 (1966)
Nikkilä, E.A., Ojala, K.: Induction of hyperglyceridemia by fructose in the rat. Life Sci.4, 937 (1965)
Nikkilä, E.A., Ojala, K.: Acute effects of fructose and glucose on the concentration and removal rate of plasma triglyceride. Life Sci.5, 89 (1966)
Portmann, O.W., Lawry, E.Y., Bruno, D.: Effect of dietary carbohydrate on experimentally induced hypercholesterinemia and hyperlipoproteinemia in rats. Proc. Soc. exp. Biol. (N. Y.)91, 321 (1956)
Reaven, G.J., Farguhar, W., Salans, L.B., Gross, R.C., Wagner, R.M.: Carbohydrate—induced lipemia. Clin. Res.12, 277 (1964)
Zakim, D., Pardini, R.S., Herman, R.H., Säuberlich, H.E.: Mechanism for the differential effects of high carbohydrate diets on lipogenesis in rat liver. Biochim. biophys. Acta (Amst.)144, 242 (1967)
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Berg, G., Matzkies, F. & Bergner, D. Verhalten der Serumlipoproteide nach Langzeitinfusion von Xylit, Fruktose und Sorbit bei gesunden Männern. Klin Wochenschr 51, 1124–1125 (1973). https://doi.org/10.1007/BF01468307
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DOI: https://doi.org/10.1007/BF01468307