Skip to main content

Advertisement

SpringerLink
Log in

Molekulare Grundlagen viral bedingter Tumoren

Molecular basis of virals induced tumors

  • Übersichten
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

The recent advances in the biology of oncorna viruses favour the hypothesis that human carcinomas may be caused by viruses. Particles isolated from various human tumors have been found to contain reverse-transcriptase activity, exhibited by all oncorna viruses. The results reported in this review demonstrate a good correlation between the reverse-transcriptase activity and the malignancy of the oncorna viruses. The development of specific inhibitors of reverse-transcriptase is, therefore useful for an effective chemotherapy in the future, and for a better understanding of the mechanism of viral oncogenesis.

Zusammenfassung

Die jüngsten Fortschritte in der Biologie der Oncornaviren begünstigen die Vorstellung, daß auch die Entstehung menschlicher Carcinome auf Viren zurückzuführen sein könnte. Denn es wurden aus einer Reihe menschlicher Tumoren Partikel gewonnen, in denen die Aktivität einer „reverse Transcriptase“ nachweisbar war. Die in diesem Bericht zitierten Befunde zeigen bemerkenswerte Beziehungen zwischen der Aktivität der „reverse Transcriptase“ und der Malignität der Oncornaviren. Die Entwicklung eines geeigneten Inhibitors der „reverse Transcriptase“ könnte daher für die Zukunft günstige Aussichten einer wirksamen klinischen Chemotherapie und ein besseres Verständnis des Mechanismus der viralen Onkogenese eröffnen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Todaro, G. J., Green, M.: Cell growth and the initiation of transformation by SV40. Proc. nat. Acad. Sci. (Wash.)55, 302 (1966).

    PubMed  Google Scholar 

  2. Westphal, H., Dulbecco, R.: Vital DNA in polyoma- and SV40-transformed cell lines. Proc. nat. Acad. Sci. (Wash.)59, 1158 (1968).

    PubMed  Google Scholar 

  3. Green, M.: Molecular basis for the attack on cancer. Proc. nat. Acad. Sci. (Wash.)69, 1036 (1972).

    PubMed  Google Scholar 

  4. Dulbecco, R., Eckhart, W.: Temperature-dependent properties of cells transformed by a thermo-sensitive mutant of polyoma virus. Proc. nat. Acad. Sci. (Wash.)67, 1775 (1970).

    PubMed  Google Scholar 

  5. Eckhart, W., Dulbecco, R., Burger, M. M.: Temperature-dependent surface changes in cells infected or transformed by a thermosensitive mutant of polyoma virus. Proc. nat. Acad. Sci. (Wash.)68, 283 (1971).

    PubMed  Google Scholar 

  6. Todaro, G. J., Green, H., Swift, M. R.: Susceptibility of human diploid fibroblast strains to transformation by SV40 virus. Science153, 1252 (1966).

    PubMed  Google Scholar 

  7. Todaro, G. J., Martin, G. M.: Increased susceptibility of Down's syndrome fibroblasts to transformation by SV40. Proc. Soc. exp. Biol. (N.Y.)124, 1232 (1967).

    Google Scholar 

  8. Aaronson, S. A., Todaro, G. J.: SV40 T-antigen induction and transformation in human fibroblast cell strains. Virology36, 254 (1968).

    Article  PubMed  Google Scholar 

  9. Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G., Kirya, B., Klein, G., Morrow, R. H., Munube, G. M. R., Pike, P., Tukei, P. M., Ziegler, J. L.: Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups. J. nat. Cancer Inst.43, 1147 (1969).

    PubMed  Google Scholar 

  10. Dmochowski, L., Seman, G., Gallager, H. S.: Viruses as possible etiologic factors in human breast cancer. Cancer (Philad.)24, 1241 (1969).

    PubMed  Google Scholar 

  11. Feller, W. F., Chopra, H. C.: Studies of human milk in relation to the possible viral etiology of breast cancer. Cancer (Philad.)24, 1250 (1969).

    PubMed  Google Scholar 

  12. Moore, D. H., Charney, J., Kramarsky, B., Lasfargues, E. Y., Sarkar, N. H., Brennan, M. J., Burrows, J. H., Sirsat, S. M., Paymaster, J. C., Vaidya, B.: Search for a human breast cancer virus. Nature (Lond.)229, 611 (1971).

    PubMed  Google Scholar 

  13. Schlom, J., Spiegelman, S., Moore, D. H.: RNA-dependent DNA polymerase activity in virus like particles isolated from human milk. Nature (Lond.)231, 97 (1971).

    PubMed  Google Scholar 

  14. Gallo, R. C., Yang, S. S., Ting, R. C.: RNA-dependent DNA polymerase of human acute leukaemic cells. Nature (Lond.)228, 927 (1970).

    PubMed  Google Scholar 

  15. Priori, E. S., Dmochowski, L., Myers, B., Wilbur, J. R.: Constant production of type C virus particles in a continuous tissue culture derived from pleural effusion cells of a lymphoma patient. Nature (Lond.) New Biol.232, 61 (1971).

    Google Scholar 

  16. Gallo, R. C., Sarin, P., Allen, P., Newton, B., Bowen, J., Priori, E. S., Dmochowski, L.: Reverse transcriptase in type C particles from a lymphoma patient. Nature (Lond.) New Biol.232, 140 (1971).

    Google Scholar 

  17. Hirshman, S. Z., Vernance, S. J., Schaffner, F.: DNA polymerase in preparations containing Australia antigen. Lancet1971 I, 1099.

    Article  Google Scholar 

  18. Bishop, J. M., Levinson, W. E., Quintrell, N., Sullivan, D., Fanshier, L., Jackson, J.: The low molecualer weight RNAs of Rous sarcoma virus. I. The 4S RNA. Virology42, 182 (1970).

    Article  PubMed  Google Scholar 

  19. Duesberg, P. H., Vogt, P. K.: Differences between the ribonucleic acids of transforming and non-transforming avian tumor viruses. Proc. nat. Acad. Sci. (Wash.)67, 1673 (1970).

    PubMed  Google Scholar 

  20. Gillespie, D., Marshall, S., Gallo, R. C.: RNA of RNA tumor viruses contains poly A. Nature (Lond.) New Biol.236, 227 (1972).

    Google Scholar 

  21. Scolnick, E. M., Aaronson, S. A., Todaro, G. J., Parks, W. P.: RNA-dependent DNA polymerase activity in mammalian cells. Nature (Lond.)229, 318 (1971).

    PubMed  Google Scholar 

  22. Penner, P. E., Cohen, L. H., Loeb, L. L.: RNA-dependent DNA polymerase: Presence in normal human cells. Biochem. biophys. Res. Commun.42, 1228 (1971).

    Article  PubMed  Google Scholar 

  23. Gallo, R. C., Personal Commun. 1972.

  24. Robert, M. S., Smith, R. G., Gallo, R. C., Sarin, P. S., Abrell, J. W.: Viral and cellular DNA polymerases: Comparison of activities with synthetic and natural RNA templates. Science176, 798 (1972).

    PubMed  Google Scholar 

  25. Hanafusa, H., Hanafusa, T.: Noninfectious RSV deficient in DNA polymerase. Virology43, 313 (1971).

    Article  PubMed  Google Scholar 

  26. Hanafusa, H., Hanafusa, T.: Further studies on RSV production from transformed cells. Virology34, 630 (1968).

    Article  PubMed  Google Scholar 

  27. Gurgo, D., Ray, R. K., Thiry, L., Green, M.: Inhibitors of the RNA- and DNA-dependent polymerase activities of RNA tumor viruses. Nature (Lond.) New Biol.229, 111 (1971).

    Google Scholar 

  28. Ting, R. C., Yang, S. S., Gallo, R. C.: Reverse transcriptase, RNA tumor virus transformation and derivatives of rifamycin SV. Nature (Lond.) New Biol.236, 163 (1972).

    Google Scholar 

  29. Chandra, P., Zunino, F., Götz, A., Wacker, A., Gericke, D., Marco, A. di, Casazza, A. M., Giuliani, F.: Template specific inhibition of DNA polymerases from RNA tumor viruses by distamycin A and its structural analogues. FEBS-Letters21, 154 (1972).

    Article  PubMed  Google Scholar 

  30. Chandra, P., Zunino, F., Götz, A., Gericke, D., Thorbeck, R., Marco, A. di: Specific inhibition of DNA-polymerases from RNA tumor viruses by some new daunomycin derivatives. FEBS-Letters21, 264 (1972).

    Article  PubMed  Google Scholar 

  31. Arcamone, F., Nicolella, V., Penco, S., Radaelli, S.: Distamicina A. Nota IV. Sintesi di analoghi con diverso numero di resti dell'acido 1-metil-4-aminopirrolo-2-carbossilico. Gazette chim. ital.99, 632 (1969).

    Google Scholar 

  32. Chandra, P., Götz, A., Wacker, A., Verini, M. A., Casazza, A. M., Fioretti, A., Arcamone, F., Ghione, M.: Some structural requirements for the antibiotic action of distamycins. FEBS-Letters16, 249 (1971).

    Article  PubMed  Google Scholar 

  33. Chandra, P., Marco, A. di, Zunino, F., Casazza, A. M., Gericke, D., Giuliani, F., Soranzo, C., Thorbeck, R., Götz, A., Arcamone, F., Ghione, M.: Influence of some antitumor antibiotics on viral neoplasia. (The role of molecular structure on the inhibition of DNA polymerases from RNA tumor viruses, viral multiplication and tumor growth by some antitumor antibiotics.) Naturwissenschaften (1972) (im Druck).

  34. Huebner, R. J., Todaro, G. J.: Oncogenes of RNA tumor viruses as determinants of cancer. Proc. nat. Acad. Sci. (Wash.)64, 1087 (1969).

    PubMed  Google Scholar 

  35. Huebner, R. J., Igel, H. J.: Immunological tolerance to gs antigens as evidence for vertical transmission. In: Perspectives in virology (McPollard, ed.), vol. VII. New York: Academic Press 1971.

    Google Scholar 

  36. Todaro, G. J., Huebner, R. J.: The viral oncogene hypothesis: New evidence. Proc. nat. Acad. Sci. (Wash.)69, 1009 (1972).

    PubMed  Google Scholar 

  37. Temin, H. M.: The protovirus hypothesis: Speculations on the significance of RNA-directed DNA synthesis for normal development and for carcinogenesis. J. nat. Cancer Inst.46, III (1971).

    Google Scholar 

  38. Kang, C. Y., Temin, H. M.: Endogenous RNA-directed DNA polymerase activity in uninfected chicken embryos. Proc. nat. Acad. Sci. (Wash.)69, 1550 (1972).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Therapeutische Biochemie der Universität Frankfurt a. M., Germany

    P. Chandra, D. Gericke, F. Zunino & R. Thorbeck

Authors
  1. P. Chandra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Gericke
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Zunino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Thorbeck
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chandra, P., Gericke, D., Zunino, F. et al. Molekulare Grundlagen viral bedingter Tumoren. Klin Wochenschr 51, 781–790 (1973). https://doi.org/10.1007/BF01468072

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01468072

Key words

Schlüsselwörter

Search

Navigation