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Serum-Alpha-Fetoprotein-Veränderungen nach partieller Hepatektomie am Menschen

Variations of human serum alpha-fetoprotein concentration after partial hepatectomy

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Summary

Alpha-fetoprotein serum concentrations were determined by radioimmunoassay in 5 patients with echinococcus involvement of the liver. In 4 cases a partial hepatectomy was possible, whereas in 1 case laparotomy had to be confined to an exposure of the liver hilus because of too many dispersed echinococcus cysts. All patients showed normal AFP levels below 20 ng/ml before operation. Within the first to third postoperative day maximal AFP increases of AFP level between 2760 and 5600 ng/ml developed, which returned to normal during the following days and weeks. One patient who was submitted to strumectomy and to the same anaesthetic liver charge had no change in her normal AFP concentration. The postoperative changes of AFP level observed are interpreted as an expression of a quick and intense liver cell regeneration following the surgical treatment.

Zusammenfassung

Bei 5 Patienten mit Leber-Echinococcus-Befall, bei denen sich in 4 Fällen eine partielle Hepatektomie und in 1 Fall wegen zu ausgedehnter Echinococcus-Cysten nur eine Laparotomie mit Leberhilusdarstellung durchführen ließ, wurden radioimmunologische Alpha-Fetoproteinspiegel vor Operation und im postoperativen Verlauf bestimmt. Alle Patienten zeigten vor Operation normale AFP-Serumspiegel unter 20 ng/ml, die innerhalb des 1. bis 3. postoperativen Tags übereinstimmend auf maximale Konzentrationen zwischen 2760 und 5600 ng/ml anstiegen, um in den folgenden Tagen und Wochen wieder in Richtung auf normale Spiegel abzusinken. Eine Patientin mit Strumektomie wies unter gleicher Narkosebelastung der Leber vor wie nach Operation normale unauffällige AFP-Konzentrationen auf. Die beobachteten postoperativen AFP-Spiegeländerungen werden als Ausdruck einer rasch und intensiv einsetzenden Leberzellregeneration im Anschluß an den operativen Eingriff interpretiert.

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Authors and Affiliations

  1. I. Medizinische Klinik und Chirurgische Klinik der Universität München, Germany

    R. Lamerz, J. Grunst, A. Fateh-Moghadam, U. Schmalhorst, H. Pichlmaier & J. Eisenburg

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  1. R. Lamerz
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  2. J. Grunst
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  3. A. Fateh-Moghadam
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  4. U. Schmalhorst
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  5. H. Pichlmaier
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  6. J. Eisenburg
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Lamerz, R., Grunst, J., Fateh-Moghadam, A. et al. Serum-Alpha-Fetoprotein-Veränderungen nach partieller Hepatektomie am Menschen. Klin Wochenschr 53, 129–133 (1975). https://doi.org/10.1007/BF01466716

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