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Immune response in human subjects at high altitude

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Abstract

Levels of immunoglobulins were determined in persons exposed to high altitude. The individuals studied included high altitude natives, sea level residents at high altitude for 2 years, and recent arrivals at high altitude. Increased IgG and IgA levels were found in high altitude natives and sea level residents at high altitude for 2 years when compared with sea level residents. In recent arrivals marked increase of IgG and IgG levels and slight rise in IgM was seen. Recent arrivals who suffered from high altitude pulmonary oedema showed marked elevation of IgG, IgM, and IgA. Immunoglobulin responses to both primary and secondary TAB inoculation were of a higher magnitude and more sustained at high altitude than at sea level.

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References

  • ALKJAERSING, N., FLETCHER, A. P. and SHERRY, S. (1962): Pathogenesis of the coagulation defect developing during pathological plasma proteolytic ("Fibrinolytic") states. II. The significance, mechanism and consequences of defective polymerisation. J. clin. Invest., 41: 917–934.

    PubMed  Google Scholar 

  • CHOHAN, I.S. (1971): Fibrinolytic activity, platelet functions and immune response at high altitude. Thesis for M.D. All India Institute of Medical Sciences, New Delhi.

    Google Scholar 

  • CHOHAN, I.S., SINGH, I. and BALAKRISHNAN, K. (1974): Fibrinolytic activity at high altitude and sodium-acetate buffer. Thrombos. Diathes. haemorrh. (Stuttg.), 32: 65–70.

    Google Scholar 

  • FAHEY, J.L. and McKELVEY, E.M. (1965): Quantitative determination of serum immunoglobulins in antibody agar plates. J. Immunol., 94: 84–90.

    PubMed  Google Scholar 

  • PATEL, R. (1971): Shortening of the clotting time of whole blood by addition of anti-HLA-anti-sera. Transplantation, 11: 104–107.

    PubMed  Google Scholar 

  • PLOW, E.F., HOUGIE, C. and EDGINGTON, T.S. (1971): Neoantigenic expressions engendered by plasmin cleavage of fibrinogen. J. Immunol., 197: 1496–1500.

    Google Scholar 

  • ROSSI, E.C. (1972): The effect of albumin upon the loss of enzymes from washed platelets. J. Lab. clin. Med., 79: 240–246.

    PubMed  Google Scholar 

  • ROTHSCHILD, M.A., ORATZ, M., FRANKLIN, E.C. and SCHREIBER, S.S. (1962): The effect of hypergammaglobulinaemia on albumin metabolism in hyperimmunized rabbits studied with albumin-I131. J. clin. Invest., 41: 1564–1571.

    PubMed  Google Scholar 

  • SINGH, I., CHOHAN, I.S. and MATHEW, N.T. (1969): Fibrinolytic activity in high altitude pulmonary oedema. Ind. J. Med. Res., 57: 210–217.

    Google Scholar 

  • SINGH, I. and CHOHAN, I.S. (1972a): Abnormalities of blood coagulation at high altitude. Int. J. Biometeor., 16: 283–297.

    Google Scholar 

  • SINGH, I. and CHOHAN, I.S. (1972b): Blood coagulation changes at high altitude predisposing to pulmonary hypertension. Brit. Heart J., 34: 611–617.

    PubMed  Google Scholar 

  • SINGH, I. and CHOHAN, I.S. (1974): Adverse changes in fibrinolysis, blood coagulation and platelet function in high altitude pulmonary oedema and their role in its pathogenesis. Int. J. Biometeor., 18: 33–45.

    Google Scholar 

  • SVEJGAARD, A., KISSMEYER-NILSEN, F. and THORSBY, E. (1970): HL-A typing of platelets. In: Histocompatibility Testing. P.I. Terasaki (ed.), Copenhagen Munksgaard, pp. 153–164.

  • TAYLOR, F.B. and MULLER-EBERHARD, H.J. (1970): Qualitative description of factors involved in the retraction and lysis of dilute whole blood clots and in the aggregation and retraction of platelets. J. clin. Invest., 49: 2068–2085.

    PubMed  Google Scholar 

  • TENGERDY, R.P. and KRAMER, T. (1968): Immune response of rabbits during short term exposure to high altitude. Nature (Lond.), 217: 367–369.

    Google Scholar 

  • TRAPANI, I.L. (1966): Altitude, temperature and the immune response. Fed. Proc., 25: 1254–1259.

    PubMed  Google Scholar 

  • TRAPANI, I.L. (1969): Environment, infection and immunoglobulin synthesis. Fed. Proc., 28: 1104–1106.

    PubMed  Google Scholar 

  • WEISER, H. and WEIHE, W.H. (1967): Effect of cold on the vitamin E requirement. Nature (Lond.), 215: 1512–1513.

    Google Scholar 

  • YANKEE, R.A., GRAFF, K.S., DOWLING, R. and HENDERSON, E.S. (1973): Selection of unrelated compatible platelets donors by lymphocyte HL-A matching. New Eng. J. Med., 288: 760–764.

    PubMed  Google Scholar 

  • YAP, E.H., EE, T.I. and SIMONS, M.J. (1971): Detection of Australia Antigen by electrocomodiffusion (E.O.D.). Southeast-Asian J. Trop. Med. Publ. Hlth., 2: 486–489.

    Google Scholar 

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Authors and Affiliations

  1. Directorate General, Armed Forces Medical Services, 110001, New Delhi, India

    I. S. Chohan

Authors
  1. I. S. Chohan
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  2. I. Singh
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  3. K. Balakrishnan
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  4. G. P. Talwar
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Chohan, I.S., Singh, I., Balakrishnan, K. et al. Immune response in human subjects at high altitude. Int J Biometeorol 19, 137–143 (1975). https://doi.org/10.1007/BF01460012

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  • DOI: https://doi.org/10.1007/BF01460012

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