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Duplication of the autosomally inherited 6-phosphogluconate dehydrogenase gene locus in tetraploid species of cyprinid fish

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Abstract

Among members of the fish family Cyprinidae,a diploid—tetraploid relationship exists. The present study on electrophoretic patterns of 6-phosphogluconate dehydrogenase indicates that such diploid members as Barbus tetrazonamaintain allelic polymorphism at a single gene locus for this enzyme. Tetraploid members such as the carp and goldfish are endowed with two separate gene loci for 6-PGD. Tetraploid evolution apparently fixed two former alleles of the same locus as two separate gene loci. Furthermore, it appears that after becoming tetraploid, the carp and goldfish developed a separate regulatory mechanism for each locus; thus preferential activation of one or the other 6-PGD locus occurs in different tissues of tetraploid species.

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Authors and Affiliations

  1. Department of Biology, City of Hope Medical Center, Duarte, California, USA

    Klaus Bender & Susumu Ohno

Authors
  1. Klaus Bender
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  2. Susumu Ohno
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Additional information

This investigation was supported in part by a grant (CA-05138) from the National Cancer Institute, U.S. Public Health Service, and in part by a research fund established in honor of General James H. Doolittle. Contribution No. 4-68, Department of Biology, City of Hope Medical Center.

Dr. Bender is a recipient of International Postdoctoral Fellowship 3 F05-TW-01198-0152 from the U.S. Public Health Service.

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Bender, K., Ohno, S. Duplication of the autosomally inherited 6-phosphogluconate dehydrogenase gene locus in tetraploid species of cyprinid fish. Biochem Genet 2, 101–107 (1968). https://doi.org/10.1007/BF01458709

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  • DOI: https://doi.org/10.1007/BF01458709

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