Skip to main content
SpringerLink
Log in

Establishment of the experimental conditions for inducing saccular cerebral aneurysms in primates with special reference to hypertension

  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

To find out the optimum experimental conditions for the induction of saccular cerebral aneurysms in primates, various procedures for inducing renal hypertension were used in cynomolgous monkeys treated with ligation of unilateral carotid artery and betaamino-propionitrile feeding.

Animals were divided into four groups. In the first group, both kidneys were simultaneously compressed with a figure-eight ligation. In the second group, the kidneys were ligated at an interval of one week. In the third and fourth groups, posterior branches of both renal arteries were ligated at the same time, or at an interval of one week, respectively. Hypertension about 200 mmHg was produced only in the last group and aneurysms were noted in more than half of these hypertensive animals.

The best procedure for renal hypertension to induce cerebral aneurysms was proved to be ligation of the posterior branches of both renal arteries at an interval of one week. We can conclude that lasting severe hypertension is essential for inducing cerebral aneurysms in monkeys.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Andrus SB, Portman OW, Riopelle AJ (1963) Comparative studies of spontaneous and experimental atherosclerosis in primates. II. Lesions in chimpanzees including myocardial infarction and cerebral aneurysms. Prog Biochem Pharmacol 4: 393–419

    Google Scholar 

  2. Carrel A (1909) Note on the production of kidney insufficiency by reduction of the arterial circulation of the kidney. Proc Soc Exp Biol Med 6: 107–108

    Google Scholar 

  3. Espinosa FH, Weir B, Noseworthy T (1984) Rupture of an experimentally induced aneurysm in a primate. Can J Neurol Sci 11: 64–68

    PubMed  Google Scholar 

  4. Goldberg SA (1926) Arteriosclerosis in domestic animals. J Am Vet Med Assoc 69: 31–47

    Google Scholar 

  5. Grollman A (1944) A simple procedure for inducing chronic renal hypertension in the mammal. Proc Soc Exp Biol Med 57: 102–104

    Google Scholar 

  6. Handa H, Hashimoto N, Nagata I, Hazama F (1983) Saccular cerebral aneurysms in rats: A newly developed animal model of the disease. Stroke 14: 857–866

    PubMed  Google Scholar 

  7. Harvey HF, Downer JL (1975) Traumatic production of an intracranial berry-like aneurysms in a monkey. Acta Neuropath (Berl) 31: 263–266

    Google Scholar 

  8. Hashimoto N, Handa H, Hazama F (1978) Experimentally induced cerebral aneurysms in rats. Surg Neurol 10: 3–8

    PubMed  Google Scholar 

  9. Hashimoto N, Handa H, Nagata I, Hazama F (1983) Saccular cerebral aneurysms in rats. Am J Pathol 110: 397–399

    PubMed  Google Scholar 

  10. Hashimoto N, Kim Ch, Kikuchi H, Kojima M, Kang Y, Hazama F (1987) Experimental induction of cerebral aneurysms in monkeys. J Neurosurg 67: 903–905

    PubMed  Google Scholar 

  11. Hassler O (1963) Experimental carotid ligation followed by aneurysmal formation and other morphological changes in the circle of Willis. J Neurosurg 20: 1–7

    PubMed  Google Scholar 

  12. Hazama F, Kataoka H, Yamada E, Kayembe K, Hashimoto N, Kojima M, Kim Ch (1986) Early changes of experimentally induced cerebral aneurysms in rats. Light-microscopic study. Am J Pathol 124: 399–404

    PubMed  Google Scholar 

  13. Hosoda Y, Iri H (1966) Angiolathyrism. 1. A histological and histochemical study on successive changes of the lathyritic rat aorta. Acta Pathol Japan 16: 239–252

    Google Scholar 

  14. Keech MK (1960) Electron microscope study of the lathyritic rat aorta. J Biophysic and Biochem Cytol 7: 539–557

    Google Scholar 

  15. Kim Ch, Kikuchi H, Hashimoto N, Kojima M, Kang Y, Hazama F (1988) Involvement of the internal elastic lamina in the development of induced cerebral aneurysms in rats. Stroke 19: 507–511

    PubMed  Google Scholar 

  16. Kojima M, Handa H, Hashimoto N, Kim Ch, Hazama F (1986) Early changes of experimentally induced aneurysms in rats: Scanning electron microscopic study. Stroke 17: 835–841

    PubMed  Google Scholar 

  17. Koletsky S (1959) Role of salt and renal mass in experimental hypertension. Arch Pathol 68: 11–22

    Google Scholar 

  18. McCormic WF, Schmalstieg EJ (1977) The relationship of arterial hypertension to intracranial aneurysms. Arch Neurol 34: 285–287

    PubMed  Google Scholar 

  19. Nagata I, Handa H, Hashimoto N, Hazama F (1981) Experimentally induced cerebral aneurysms in rats: Part VI. Hypertension. Surg Neurol 14: 477–479

    Google Scholar 

  20. Østergaad JR, Msc EH (1985) Incidence of multiple intracranial aneurysms. Influence of arterial hypertension and gender. J Neurosurg 63: 49–55

    PubMed  Google Scholar 

  21. Roy VA Jr, Sundt TH Jr, Murphey F (1970) Experimental subarachnoid hemorrhage: A study of spasm with the production of aneurysms. Stroke 1: 248–252

    PubMed  Google Scholar 

  22. Sekher LN, Heros RC (1981) Origin, growth, and rupture of saccular aneurysms: A review. Neurosurgery 8: 248–260

    PubMed  Google Scholar 

  23. Stehbens WE (1963) Cerebral aneurysms in animals other than men. J Pathol Bacteriol 86: 161–168

    Google Scholar 

  24. Stroia LN, Bohr DF, Vocke L (1954) Experimental hypertension in the hamster. Am J Physiol 179: 154–158

    PubMed  Google Scholar 

  25. Tindall GT, Odom GL, Dillon ML, Cupp HB Jr, Mahaley MS Jr, Greenfields JC Jr (1963) Direction of blood flow in the internal and external carotid arteries following occlusion of the ipsilateral common carotid artery. Observation in 19 patients. J Neurosurg 20: 985–994

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery of the Fukui Red Cross Hospital, Fukui

    Ch. Kim

  2. Department of Neurosurgery of the Kyoto University Hospital, Kyoto

    H. Kikuchi & N. Hashimoto

  3. Department of Pathology, Shiga University of Medical Science, Otsu, Japan

    F. Hazama & H. Kataoka

Authors
  1. Ch. Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Kikuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Hazama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Kataoka
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, C., Kikuchi, H., Hashimoto, N. et al. Establishment of the experimental conditions for inducing saccular cerebral aneurysms in primates with special reference to hypertension. Acta neurochir 96, 132–136 (1989). https://doi.org/10.1007/BF01456172

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01456172

Keywords

Search

Navigation