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The effects of inbreeding on DNA profile frequency estimates using PCR-based loci

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Abstract

Estimates of inbreeding were determined using Wright's FST for loci used for PCR-based forensic analyses. The populations analyzed were African Americans, Caucasians, Hispanics, and Orientals. In most cases the FST values at each locus were less than 0.01. The FST values over all loci for African Americans, Caucasians, and Orientals ranged from 0.0015 to 0.0048. No substantial differences were observed for DNA profile frequency estimates when calculated under the assumption of independence or with the incorporation of FST.

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Authors and Affiliations

  1. Forensic Science Research and Training Center, FBI Academy, 22135, Quantico, VA, USA

    Bruce Budowle

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  1. Bruce Budowle
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Editor's comments

The author provides an empirical study to accompany the papers by Balding and Nichols and Brookfield in this volume. As may have been expected, FST values for large heterogeneous populations such as ‘Caucasian’ or ‘African American’ are very small.

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Budowle, B. The effects of inbreeding on DNA profile frequency estimates using PCR-based loci. Genetica 96, 21–25 (1995). https://doi.org/10.1007/BF01441148

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