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Zur biologischen Wirkung der aktiven Komponente (Tetrapeptid) des synthetischen Gastrins (Sekretionsstudien am Heidenhain-Pouch)

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Zusammenfassung

An Magenfistelhunden mit einem vagal denervierten (Heidenhain-) Pouch wurden vergleichende Untersuchungen über die sekretorische Magenfunktion nach Nahrungsstimulation (endogenes Gastrin) und Tetrapeptidstimulation (wirksame Komponente des synthetischen Gastrins) vorgenommen. Unter den gewählten experimentellen und pharmakologischen Bedingungen zeigte die Sekretion aus dem gefistelten Nebenmagen ein identisches Verhalten, d. h. die biologische Wirksamkeit des synthetischen Tetrapeptids entsprach der des nach Stimulation der gastralen Phase der Magensekretion freigesetzten Gastrins.

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Authors and Affiliations

  1. Chirurg. Poliklinik der Universität München, Pettenkoferstraße 8a, 8000, München

    R. F. Lick, H. Welsch, W. Hart, D. Balser & K. Bennewitz

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  1. R. F. Lick
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  2. H. Welsch
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  3. W. Hart
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  4. D. Balser
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  5. K. Bennewitz
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Lick, R.F., Welsch, H., Hart, W. et al. Zur biologischen Wirkung der aktiven Komponente (Tetrapeptid) des synthetischen Gastrins (Sekretionsstudien am Heidenhain-Pouch). Arch. f. klin. Chir 315, 186–198 (1966). https://doi.org/10.1007/BF01440185

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  • DOI: https://doi.org/10.1007/BF01440185

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