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Die Analyse einiger theoretischer Probleme bei der Verwendung von Erzeugnissen aus Kollagen in der Medizin

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Zusammenfassung

Die Autoren erörtern die Gründe, weshalb Kollagen ein geeigneter Rohstoff für klinisch verwendbare Erzeugnisse ist. Zu den günstigen Eigenschaften gehört große mechanische Festigkeit, minimale Antigenizität, kontrollierte Resorptionsgeschwindigkeit, Bindungsfähigkeit und eventuelle Stimulans der Fibrillogenese. Die einzelnen Anwendungsformen der Kollagenerzeugnisse werden kritisch erörtert. Größte Aufmerksamkeit wird Gefäßprothesen gewidmet, bei denen die Notwendigkeit der hohen Porosität der Gefäßwand als Bedingung erfolgreicher Heilung betont wird. Die Autoren bevorzugen eine Prothesenkombination aus Kollagen und Kunstgewebe mit einer Anticoagulationsschicht an der Innenseite der Kollagenröhre. Kollagenschaum kann als Blutstillmittel, Tampon und Verbandstoff verwendet werden. Eine Klassifizierung der Kollagenfaden als Nähmaterial wird unterbreitet. Membranen zur Deckung von Hautdefekten als Prävention der Adhesionen und als Ersatz weiterer Organe werden als weitere Formen der Anwendung besprochen. Die Autoren glauben an eine weitere Verbreitung der Kollagenerzeugnisse, die einer Reihe biologischer Anforderungen die auf Prothesen und eventuell anderes Material gestellt werdem, voll entsprechen.

Summary

The authors discuss the reasons why collagen is a raw material most suitable for products used for clinical purposes. Mechanical strength, minimal antigenicity, possibility of controlled resorption guat binding capacity and possible stimulating effect upon fibrogenesis are some of the useful properties. The individual types of collagen products are critically considered. Utmost attention is paid to vessel prothesis in which the necessity of high porosity walls for successful healing is stressed. The authors give preference to combined collagen-dacron prothesis with anticoagulation layer of heparin inside the collage tube. Collagen foam may be used as hemostaticum, tampon and wound dressing material. Membranes for dressing tissue defects, pressenting adhesion formation and for substitution of further organs are other possible forms of application. The authors believe than manufacturing of collagen products will increase as they comply with a number of biological demands upon prosthesis and further possible material.

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Authors and Affiliations

  1. Institut für Arbeitshygiene und Berufskrankheiten, Prag

    M. Chvapil

  2. Institut für klinische und experimentelle Chirurgie, Prag

    M. Krajíček

  3. Ustav Hygieny Pràce a Chorob z Povoláni, Vinohrady, Šrobárova Ulice 48, Praha 10

    M. Chvapil

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  1. M. Chvapil
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  2. M. Krajíček
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Vorgetragen am IV. Symposium über kollagene Eiweißstoffe in Hluboká im Mai 1964.

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Chvapil, M., Krajíček, M. Die Analyse einiger theoretischer Probleme bei der Verwendung von Erzeugnissen aus Kollagen in der Medizin. Arch. f. klin. Chir 318, 80–101 (1967). https://doi.org/10.1007/BF01439078

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