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O,N-Dimethylation of 5,6-dihydroxynicotinic acid

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Abstract

AnO,N-dialkylation product, 1-methyl-5-metlioxy-6-oxo-1,6-diliydropyridine-3 carboxylic acid, is formed in the reaction of 5,6-dihydroxynicotinic acid with dimethylsulfate.

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References

  1. R. A. Abramovitch,Pyridine and its Derivatives, 1974, Pt. III, 745.

  2. S. L. Shapiro, K. Weinberg, and L. Freedman,J. Am. Chem. Soc., 1959,81, 5140.

    Google Scholar 

  3. D. A. Prins,Rec. Trav. Chim. Pays-Bas, 1957,76, 58.

    Google Scholar 

  4. M. Kawazu, T. Kauno, S. Saito and H. Tomaki,J. Med. Chem., 1972,15, 914.

    PubMed  Google Scholar 

  5. US pat. 2.212, Swiss pat. 212.521:Chem. Abstrs., 1941,35, 4665.

    Google Scholar 

  6. E. Breitmaier and W. Voelter,13 C NUR Spectroscopy, Verlag Chemie, Weinheim-New York, 1978, 200.

    Google Scholar 

  7. E. Breitmaier, G. Haas, and W. Voelter,Atlas of Carbon 13 NMR Data, Heyden, 1979,2, 2364, 2365, 2367.

    Google Scholar 

  8. E. Breitmaier and W. Voelter,13 C NMR Spectroscopy, Verlag Chemie, Weinheim-New York, 1978, Chap. 3.2.2.

    Google Scholar 

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Authors and Affiliations

  1. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 117977, Moscow, Russian Federation

    L. G. Stolyarova & L. V. Gol'tsova

  2. National Research Center for Biologically Active Compounds, 23 ul. Kirova, 142450, Staraya Kupavna, Moscow Region, Russian Federation

    O. G. Kesarev, A. I. Chernyshev & L. D. Smirnov

Authors
  1. L. G. Stolyarova
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  2. O. G. Kesarev
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  3. A. I. Chernyshev
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  4. L. V. Gol'tsova
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  5. L. D. Smirnov
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Additional information

Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1554–1555, June, 1996.

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Stolyarova, L.G., Kesarev, O.G., Chernyshev, A.I. et al. O,N-Dimethylation of 5,6-dihydroxynicotinic acid. Russ Chem Bull 45, 1483–1484 (1996). https://doi.org/10.1007/BF01434238

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  • DOI: https://doi.org/10.1007/BF01434238

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