Summary
The morphological modifications of the cerebellar cortex have been evaluated in eight cats with chronic electrodes implanted in the anterior vermis. In a control animal a silastic lamina without electrodes was implanted. Four animals received intermittent stimulations up to 11 hours in one case and 100 hours in the other 3. The stimulation was carried out with pulses of 0.5 msc, 200 cps, and a charge per phase of 0.68 μc. Microscopic examination of the cerebellum showed that the experimental implanting of prostheses on the cerebellar vermis produces tissue lesions consisting of fibrous reaction, imprinting of the cortex, gliosis, and loss of Purkinje cells. These lesions are independent of the electric stimulation, and seem to be related to the pressure of foreign material against the cortex.
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Brown, W. J., Babb, T. L., Soper, H. V., Lieb, J. P., Ottino, C. A., Crandall, P. H., Tissue reactions to long-term electrical stimulation of the cerebellum in monkeys. J. Neurosurg.47 (1977), 366–379.
Cooke, P. M., Snider, R. S., Some cerebellar influences on electrically induced cerebral seizures. Epilepsia4 (1953), 19–28.
Cooper, I. S., Gilman, S., Chronic stimulation of the cerebellar cortex in the therapy of epilepsy in the human. In: Neural organization and its relevance to prosthetics, pp. 371–375 (Fields, W. S., ed.). New York: Intercontinental Medical Book Corp. 1973.
Cooper, I. S., Amin, I., Gilman, S., The effect of chronic stimulation of cerebellar cortex on epilepsy in man. In: The cerebellum, epilepsy and behavior, pp. 119–171 (Cooper, I. S., Riklan, M., Snider, R. S., eds.). New York: Plenum Press. 1974.
Cooper, I. S., Riklan, M., Amin, I., Waltz, J. M., Cullinan, T., Chronic cerebellar stimulation in cerebral palsy. Neurology26 (1976), 744–753.
Cooper, I. S., Amin, I., Riklan, M., Waltz, J. M., Poon, T. P., Chronic cerebellar stimulation in epilepsy. Arch. Neurol.33 (1976), 559–570.
Dauth, G. W., Defendini, R., Gilman, S., Tennyson, V. M., Kremzner, L. T., Long-term surface stimulation of the cerebellum in the monkey. I. Light microscopic, electrophysiologic and clinical observations. Surg. Neurol.7 (1977), 377–384.
Dow, R. S., Fernandez-Guardiola, A., Manni, E., The influence of the cerebellum on experimental epilepsy. EEG Clin. Neurophysiol.14 (1962), 383–398.
Gilman, S., Dauth, G. W., Tennyson, V. M., Kremzner, L. T., Chronic cerebellar stimulation in the monkey: preliminary observations. Arch. Neurol.32 (1975), 474–477.
Hemmy, D. C., Larson, S. J., Sances, A., Millar, E. A., The effect of cerebellar stimulation on focal seizure activity and spasticity in monkeys. J. Neurosurg.46 (1977), 648–653.
Manrique, M., Vaquero, J., Oya, S., Lozano, A. P., Herrero, J., Bravo, G., Chronic paleocerebellar stimulation for the treatment of neuromuscular disorders. Four cases reported. Presented at the 7heme Symposium of the World Society for Stereotactic and Functional Neurosurgery. São Paulo, Brasil, June 23–25, 1977.
Moruzzi, G., Sui rapporti fra cerebelletto e corteccia cerebrale. Arch. Fisiol.41 (1941), 87–139.
Rajjoub, R. K., Wood, J. H., v. Buren, J. M., Significance of Purkinje cells density in seizure suppression by chronic cerebellar stimulation. Neurology26 (1976), 645–650.
Tennyson, V. M., Kremzner, L. T., Dauth, G. W., Gilman, S., Chronic cerebellar stimulation in the monkey. Electron microscopic and biochemical observations. Neurology25 (1975), 650–654.
Tennyson, V. M., Kremzner, L. T., Dauth, G. W., Defendini, R., Gilman, S., Long-term surface stimulation of the cerebellum in the monkey. II. Electron microscopic and biochemical observations. Surg. Neurol.8 (1977), 17–29.
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Vaquero, J., Lozano, A.P., Oya, S. et al. Chronic implanting of electrodes in the cerebellar vermis of the cat. Morphological findings. Acta neurochir 46, 259–266 (1979). https://doi.org/10.1007/BF01430587
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DOI: https://doi.org/10.1007/BF01430587