Summary
The authors have studied the histological, histochemical, and ultrastructural aspects of eight corticectomies of epileptogenic foci in the medial surfaces of frontal lobes.
In all cases they were able to see more gliosis and fewer neurons than normal. The shape and number of dendritic spines were thought to be normal with the Golgi-Cox method. The histochemical study showed an increment of activity of Glucose-6-Phosphatase, Glucose-6-Phosphatedehydrogenase, adenosintriphosphatase, and acid phosphatase. The electron microscope showed, in every case, a variety of changes, among which the authors can point to perivascular lipid accumulation, and an increase of lipofuscin bodies in the cytoplasm of pyramidal cells.
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References
Barka, T., Anderson, P. J., Histochemical methods for acid phosphatase using hexazonium pararosanilin as coupler. J. Histochem. Cytochem.10 (1962), 741–753.
Brotchi, J., Astrocytes réactionnels et épilepsie. Acta neurol. belg.72 (1972), 137–145.
Brown, W. J., Structural substrates of seizure foci in the human temporal lobe. In: The fenomena of epilepsy in man, pp. 339–374 (Brazier, M., ed.). 1973.
Gomori, G., Microtechnical demonstration of phosphatase in tissue sections. Proc. Soc. Exp. Biol. Med.42 (1939), 23–27.
Jensen, I., Klinken, L., Temporal lobe epilepsy and neuropathology. Histological findings in resected temporal lobes correlated to surgical results and clinical aspects. Acta Neurol. Scand.54 (1976), 391–414.
Nachlas, M. M., Tsou, K. C., Souza, E., Chang, C. S., Seligman, A. M., Cytochemical demonstration of succinic-deshydrogenase by the use of a new p-nitrophenyl substituted ditetrazole. J. Histochem. Cytochem.5 (1957), 420–436.
Ogawa, K., Saito, T., Mayahara, H., The site of ferricyanide reduction by reductases within mitochondria as studied by electron microscopy. J. Histochem. Cytochem.16 (1968), 49–57.
Pope, A., Morris, A., Jasper, H., Elliot, K., Penfield, W., Cited by Adams, C. W., in: Neurochemistry (Adams, C. W., ed.). Amsterdam: Elsevier. 1965.
Richterich, R., Zur Technik des histochemischen Esterasennachweises. Acta Anat.14 (1952), 69–89.
Scheibel, M. E., Crandall, P. H., Scheibel, A. B., The hippocampaldentate complex in temporal lobe epilepsy. A Golgi study. Epilepsia15 (1974), 55–80.
Talairach, J., Bancaud, J., Szikla, G., Bonis, A., Geier, S., Vedrenne, C., Approche nouvelle de la neurochirurgie de l'épilepsie. Méthodologie stéréotaxique et résultats thérapeutiques. Neurochirurgie20 (1974), suppl. 1, 1–240.
Tower, S., Cited by Wegmann, R., Petrescu, A., Marcy, R., Eymard, P., Modifications histoenzymologiques de système nerveux central au cours de l'épilepsie et du traumatisme. Rev. Neurol.123 (1970), 153–172.
Vaquero, J., Oya, S., Manrique, M., Pérez Lozano, A., Buján, J., Neurona oscura y epilepsia. Arch. Fac. Med. (Madrid)33 (1978), 155–162.
Wachstein, M., Meisel, E., On the histochemical demonstration of glucose-6-phosphatase. J. Histochem. Cytochem.4 (1956), 592.
— —, Niedzwiedz, A., Histochemical demonstration of mitochondrial adenosine triphosphatase with the lead-adenosine triphosphatase technique. J. Histochem. Cytochem.8 (1960), 387–388.
Ward, A. A., Jr., The epileptic neurons: chronic foci in animals and man. In: Basic mechanisms of the epilepsies, pp. 263–288 (Jasper, H. H., Ward, A. A., Jr., Pope, A., eds.). Boston, Mass.: Little Brown and Co. 1969.
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Vaquero, J., Oya, S., Manrique, M. et al. Medial frontal epilepsy: Histological, histochemical, and ultrastructural study. Preliminary observations. Acta neurochir 46, 233–241 (1979). https://doi.org/10.1007/BF01430585
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DOI: https://doi.org/10.1007/BF01430585