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Haben die Sphaeridien in den Zellkernen kranker Gewebe eine pathognomonische Bedeutung?

Are the sphaeridies in the cells of pathological tissues of pathognomonic significance?

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Summary

In the caryoplasm of man and 24 species of mammals, birds, and reptiles of 14 different orders round structures with a diameter of 0,3–1,5 μ have been observed which are named sphaeridies. They consist of an externum with 70–100 Å thick filaments and an internum with few or many electron-dense granula with a diameter of 150–200 Å. In the internum one finds inclusions of electron-dense globules, crystalloids, and membrane-bound vesicles. Dependent on these structural differences four types are described: a filamentous, a granular, a globular, and a membranous type. They are found in nearly all tissues except granulocytes and striated muscle. They are very frequent in the cells of the lymphatic system and in hormone-sensitive organs like the adrenal gland. Sphaeridies are described in experimental infections of animals withSchistosoma mansoni, Plasmodium berghei, Theileria parva, and with fowlpox virus, and in man in the atypical lymphocytes of infectious mononucleosis, in carcinoma of the uterus and mamma, in psoriasis vulgaris, and in lichen ruber planus. The morphology of the sphaeridies is identical in the cells of the healthy and pathological tissues. The results of earlier investigations are compiled in a list and discussed. The sphaeridies are not of viral origin and they have no pathognomonic significance. Their meaning is a problem of general cytology. It is supposed that the sphaeridies are a structure of the caryoplasm associated with the synthesis of protein in the nucleus.

Zusammenfassung

Die als Sphaeridien bezeichneten, ca. 0,3–1,5 μ großen, kugeligen Karyoplasmadifferenzierungen konnten beim Menschen und bei 24 Wirbeltierarten aus 14 verschiedenen Ordnungen in fast allen Geweben nachgewiesen werden. Ein filamentöses Externum umschließt ein granuläres Internum, in das weitere Strukturelemente eingelagert sein können. Dadurch ergeben sich vier verschiedene Typen: ein filamentöser, ein granulärer, ein globulärer und ein membranöser Typ. Die vergleichende Untersuchung in den Geweben von gesunden und an verschiedenen Infektionskrankheiten, Neoplasien und Dermatosen leidenden Menschen und Tieren ergibt in Übereinstimmung mit den meisten Einzelbeobachtungen in der Literatur keine wesentlichen Unterschiede der Sphaeridienstruktur in gesunden und pathologisch veränderten Zellen. Somit kommt den Sphaeridien keine pathognomonische Bedeutung zu. Ihre Funktion stellt ein Problem der allgemeinen Cytologie dar. Es wird hypothetisch angenommen, daß sie eine Rolle bei der Proteinsynthese im Kern spielen.

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  1. Anatomisches Institut der Universität Hamburg, Deutschland

    D. W. Büttner & E. Hoestmann

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Büttner, D.W., Hoestmann, E. Haben die Sphaeridien in den Zellkernen kranker Gewebe eine pathognomonische Bedeutung?. Virchows Arch. path Anat. 343, 142–163 (1967). https://doi.org/10.1007/BF01429735

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