Zusammenfassung
Die Niere von Patienten mit Leptospirose wurde mittels Elektronenmikroskopie und biochemisch-enzyniatischer Bestimmungen untersucht. Verminderte enzymatische Aktivität wurde bei einer morphologischen Läsion der Tubuluszellen gefunden. Cytosome und Cytosegresome wurden mit größerer Häufigkeit in einigen veränderten Tubuluszellen nachgewiesen. Ferner werden pathologische Veränderungen von Mitochondrien, Bürstensaum, Capillaren und Glomerula beschrieben. Diese Befunde sind mit einer toxischen Wirkung auf Blutcapillaren und auf Tubuluzellen vereinbar, welche die Mereninsuffizienz der Leptospirose erklären kann.
Summary
Biochemical enzymatic assays with electron microscopic studies of biopsied human kidney were made in leptospirosis. There was decreased enzymatic activity together with morphological evidence of tubular cell injury. Cytosomes and cytosegresomes were more abundant in some of the altered cells; mitochondrial and brush border injury were present. Damage to capillaries and a mild glomerular alteration were noted. These data are consistent with a circulating toxin which, acting on capillaries and/or directly on the tubular cell, might be responsible for the kidney failure seen in leptospirosis.
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This work was supported by a grant of the I.B.E.P.E.G.E.
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de Brito, T., Penna, D.O., Pereira, V.C. et al. Kidney biopsies in human leptospirosis: A biochemical and electron microscopy study. Virchows Arch. path Anat. 343, 124–135 (1967). https://doi.org/10.1007/BF01429733
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DOI: https://doi.org/10.1007/BF01429733