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The ins and outs of yeast vacuole trafficking

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Summary

Vacuoles are ubiquitous organelles in the fungal and plant kingdoms. They serve a variety of functions and are important for cell homeostasis. A constant turnover of proteins and membranes makes vacuoles dynamic organelles. Various transport pathways share the vacuole as their joint destination. The trafficking pathways are regulated independently. In yeast cells many components of the protein and membrane transport machinery are known. Recent years have seen much progress in our understanding of the protein-sorting pathways and the biogenesis of this organelle. Improvements of our understanding of the vesicular transport pathways and vacuolar membrane fusion are reviewed.

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Abbreviations

ALP:

alkaline phosphatase

AP:

adaptor protein complex

CPY:

carboxypeptidase Y

CPS:

carboxypeptidase S

NSF:

N-ethylmaleimide-sensitive membrane fusion protein

PIP:

phos-phatidyl inositol phosphate

PVC:

prevacuolar compartment

SNAP:

soluble N-ethylmaleimide-sensitive factor attachment protein

SNARE SNAP:

receptor

TGN:

trans-Golgi network

vam :

vacuolar morphology (mutant)

vps :

vacuolar protein sorting (mutant)

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  1. M. Götte

    Present address: Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA

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  1. Molekulare Genetik, Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg, D-37077, Göttingen, Federal Republic of Germany

    M. Götte & T. Lazar

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Götte, M., Lazar, T. The ins and outs of yeast vacuole trafficking. Protoplasma 209, 9–18 (1999). https://doi.org/10.1007/BF01415696

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