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Effect of ketanserin on 5-hydroxytryptamine-induced constriction in isolated, perfused canine basilar arteries exposed to blood

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Summary

The blocking effect of ketanserin, a 5-hydroxytryptamine (5-HT)2 receptor antagonist, was examined on responses to intraluminal 5-HT or potassium chloride (KC1) in isolated and perfused canine basilar arteries before and after extraluminal whole blood by means of the stainless-steel cannula inserting method. Four hours after the application of blood, the constriction to 5-HT was significantly enhanced, while that to KC1 was significantly attenuated. The absolute value in the decrease of perfusion pressure for the 5-HT-induced constriction sensitive to ketanserin was much greater after the blood application than that before the application. It is suggested that the augmentation of cerebrovascular responses to 5-HT in the early stage immediately after subarachnoid haemorrhage (SAH) might be mediated by 5-HT2 receptors at least in part. This early constrictor mechanism may be implicated in the aetiology of the following late stage of cerebral vasospasm after SAH.

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Authors and Affiliations

  1. Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan

    T. Tsuji M.D.

  2. Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada

    D. A. Cook

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  1. T. Tsuji M.D.
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  2. D. A. Cook
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Tsuji, T., Cook, D.A. Effect of ketanserin on 5-hydroxytryptamine-induced constriction in isolated, perfused canine basilar arteries exposed to blood. Acta neurochir 138, 1109–1117 (1996). https://doi.org/10.1007/BF01412316

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