Summary
Stereotactic devices for experimental Gamma Knife irradiation and magnetic resonance imaging (MRI) have recently been developed for experimental studies using rats [6, 7]. The present study examined the accuracy of these devices using the following two approaches. In the first approach, Gamma Knife irradiation was performed using the stereotactic device with targets based on a standard stereotactic atlas. Gadolinium-enhanced T1-weighted magnetic resonance imaging was performed using the MRI stereotactic device. Animals were then sacrificed after Evans blue injection, and the rat brain was sliced using an attachment to the stereotactic device. The center coordinates of the gadolinium-enhanced area from the MRI and Evans blue-stained area from the tissue sections were obtained using a computer-assisted image analysis system. These coordinates were compared with the target coordinates planned from the stereotactic atlas. In the second approach, a thermoluminescence dosimeter was implanted in the rat brain. Stereotactic MRI was performed using the stereotactic MRI device, and the coordinates of the implant were obtained. Gamma Knife irradiation was then performed at this target using the stereotactic device. The absorbed dose was measured and compared with the planning dose.
These experiments demonstrated a spatial error of 0.6 mm (standard error ± 0.07) between Gamma Knife irradiation based on a comparison of the atlas coordinates and the lesion, and a spatial error of 1.0 mm (standard error ± 0.13) based on a comparison of the stereotactic MR images and the lesion. Gamma Knife irradiation based on MR images using the stereotactic device demonstrated a maximum error of 10% in absorbed dose at the target center. Together, the stereotactic devices for Gamma Knife irradiation and magnetic resonance imaging provide useful tools for Gamma Knife research in an animal model.
Similar content being viewed by others
References
Barcia Salorio JL, Roldan P, Hernandez G, Lopez-Gomez L (1985) Radiosurgical treatment of epilepsy. Appl Neurophysiol 48: 400–403
Barcia-Salorio JL, Barcia JA, Hernandez G, Lopez-Gomez L (1994) Radiosurgery of epilepsy. Long-term results. Acta Neurochir [Suppl] 62: 111–113
Barcia-Salorio JL, Barcia JA, Roldan P, Hernandez G, Lopez-Gomez L (1993) Radiosurgery of epilepsy. Acta Neurochir (Wien) [Suppl] 58: 195–197
Bernstein MB, Marotta T, Stewart P, Glen J, Resch L, Henkelman M (1990) Brain damage from125I brachytherapy evaluated by MR imaging, a blood-brain barrier tracer, and light and electron microscopy in a rat model. J Neurosurg 73: 585–593
Hellstrand E, Abraham-Fuchs K, Jernberg B, Kihlstrom L, Knutsson E, Lindquist C, Schneider S, Wirth A (1993) MEG localization of interictal epileptic focal activity and concomitant stereotactic radiosurgery. A non-invasive approach for patients with focal epilepsy. Physiol Meas 14: 131–136
Kamiryo T, Berk HW, Lee KS, Kassell NF, Steiner L (1993) A stereotactic device for experimental Gamma Knife radiosurgery in rats. A technical note. Acta Neurochir (Wien) 125: 156–160
Kamiryo T, Berr SS, Lee KS, Kassell NF, Steiner L (1995) Enhanced magnetic resonance imaging of the rat brain using a stereotactic device with a small head coil. A technical note. Acta Neurochir (Wien) 133: 87–92
Kamiryo T, Kassell NF, Thai QA, Lopes MBS, Lee KS, Steiner L (1996) Histological changes in the normal rat brain after gamma surgery. Acta Neurochir (Wien) 138: 451–459
Kondziolka D, Lunsford LD, Claassen D, Maitz AH, Flickinger JC (1992) Radiobiology of radiosurgery: Part 1. The normal rat brain model. Neurosurgery 31: 271–279
Leksell L (1971) Stereotaxic radiosurgery in trigeminal neuralgia. Acta Chirurgica Scand 137: 311–314
Lindquist C, Kihlstrom L, Hellstrand E (1991) Functional neurosurgery — a future for the gamma knife? Stereotact Funct Neurosurg 57: 72–81
Lo EH, DeLaPax RL, Frankel KA, Poljak A, Brennan KM, Woodruff KH, Valk PE, Steinberg GK, Fabrikant JI (1991) MRI and PET of delayed heavy-ion radiation injury in the rabbit brain. Int J Radiation Oncology Biol Phys 20: 689–696
Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic Press, Orlando, Florida
Rand RW, Jacques DB, Melbye RW, Copcutt BG, Levenick MN, Fisher MR (1993) Leksell Gamma Knife treatment of tic douloureux. Stereotact Funct Neurosurg 61: 93–102
References
Kamiryo T, Berk HW, Lee KS, Kassell NF, Steiner L (1993) A stereotactic device for experimental gamma knife radiosurgery in rats. A technical note. Acta Neurochir (Wien) 125: 156–160
Kamiryo T, Berr SS, Lee KS, Kassell NF, Steiner L (1995) Enhanced magnetic resonance imaging of the rat brain using a stereotactic device with small head coil: technical note. Acta Neurochir (Wien) 133: 87–92
Kamiryo T, Lopes MBS, Berr SS, Lee KS, Kassell NF, Steiner L (1996) Occlusion of the anterior cerebral artery after gamma surgery in a rat (in manuscript)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kamiryo, T., Berr, S.S., Berk, H.W. et al. Accuracy of an experimental stereotactic system for MRI-based Gamma Knife irradiation in the rat. Acta neurochir 138, 1103–1108 (1996). https://doi.org/10.1007/BF01412315
Issue Date:
DOI: https://doi.org/10.1007/BF01412315