Abstract
The penetration ability of indomethacin in neutral and positively charged monolayers has been studied. Neutral monolayers of cholesterol and dipalmitoyl phosphatidyl choline present a slight but significant increase of surface pressure. The presence of stearylamine in the films results in an increase of surface pressure due to an electrostatic effect between the carboxylic anion of indomethacin and the polar head group of the stearylamine. These values can afford a reference point to choose the best lipid composition of liposomes encapsulating indomethacin to avoid the drug causing leakage of liposomes.
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References
Mayer LD, Bally MB, Hope MJ, Cullis PR (1986) Chem Phys Lipids 40:333–345
Hernández J, Estelrich J, Pouplana R (1987) J Microencapsulation 4:315–320
Gürsoy A, Akbuga J, Eroglu L, Ulutin S (1988) J Pharm Pharmacol 40:53–54
Verger R, de Haas GH (1973) Chem Phys Lipids 10:240–254
Hwang S-B, Shen TY (1981) J Med Chem 24:1202–1211
Demel RA, de Kruijff B (1976) Biochim Biophys Acta 457:109–132
Kirby CJ, Gregoriadis G (1980) Life Sci 27:2223–2230
D'Silva JB, Notari RE (1982) J Pharm Sci 71:1394–1398
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Hernández, J., Estelrich, J., Montero, M.T. et al. The action of indomethacin on neutral and positively charged monolayers. Colloid & Polymer Sci 267, 622–626 (1989). https://doi.org/10.1007/BF01410439
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DOI: https://doi.org/10.1007/BF01410439