Summary
Neomycin and a benzodiazepine derivative (RO16-0521) inhibit similarly cholesterol absorption in man but the serum cholesterol level is reduced only by neomycin. Reason(s) for the difference are unknown. Ketoconazole inhibits 14α-demethylation of lanosterol so that cholesterol synthesis is reduced. The agent inhibits also cholesterol absorption. The serum cholesterol level is reduced by about 20%, the lowering being potentiated by a simultaneous cholestyramine treatment.
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Kesäniemi, Y.A., Miettinen, T.A. Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole. Eur J Clin Pharmacol 40, S65–S67 (1991). https://doi.org/10.1007/BF01409412
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DOI: https://doi.org/10.1007/BF01409412