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Lactat in Hirntumoren

Eine vergleichende Untersuchung mit Nicht-Tumor-Geweben

Lactic acid in brain tumors

Comparative investigations with nontumoral tissues

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Zusammenfassung

Der Lactat-Gehalt in Hirntumoren ist nicht signifikant erhöht gegenüber dem in normalen Hirngeweben. Diese Aussage beruht auf den Ergebnissen zweier verschiedener Bestimmungsmethoden in 43 Fällen von Hirntumoren und 24 Fällen von nichtneoplastischen Hirngeweben (Mensch, Affe, Kaninchen, Maus). Der Befund wird diskutiert.

Summary

We determined the amount of lactic acid in 43 human brain tumors and in 24 non neoplastic brain tissues of man, monkey, rabbit and mice. Though we used two different methods of determination of lactate we could not find any significant increase of lactic acid in tumors compared to that of non tumor brain tissues. The results were discussed.

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Literatur

  • Barker, S. B., andW. H. Summerson, The colorimetric determination of lactic acid in biological material. J. Biol. Chem.138 (1941), 535–554.

    Google Scholar 

  • Brierley, J. B., andH. McIlwain, Metabolic properties of cerebral tissues modified by neoplasia and by freezing. J. Neurochem.1 (1956), 109–118.

    PubMed  Google Scholar 

  • Cori, C. F., andG. T. Cori, The carbohydrate metabolism of tumors. J. Biol. Chem., Baltimore65 (1925), 397–405.

    Google Scholar 

  • Dohr, H., Über die Atmung von menschlichen Hirntumoren und Hirngewebe in vitro. Acta Neurochir.9 (1961), 543–553.

    Google Scholar 

  • Kaasik, A. E., L. Nilsson, andB. K. Siesjö, Acid-base and lactate-pyruvate changes in brain and CSF in asphyxia and stagnant hypoxia. Scand. J. Lab. Clin. Invest., 1968, Suppl. 102, III: C.

    Google Scholar 

  • Kirsch, W. N., Substrates of glycolysis in intracranial tumors during complete ischemia. Cancer Res.25 (1965), 432–439.

    PubMed  Google Scholar 

  • Leusen, J., J. Weyne, andG. Demeester, Acid-base and laetate-pyruvate changes in CSF and brain. Scand. J. Lab. Clin. Invest., 1968, Suppl. 102, I: G.

    Google Scholar 

  • Scholz, R., H. Schmitz, Th. Bucher undS. O. Lampen, Eine enzymatische Bestimmung der L(+)-Milchsäure mit Milchsäuredehydrogenase. Biochem. Z.331 (1959), 71–86.

    Google Scholar 

  • Severinghaus, J. W., Outline of H+-blood flow relationships in brain. Scand. J. Lab. Clin. Invest., 1968, Suppl. 102, VIII: K.

    Google Scholar 

  • Weber, G., Atmung und aerobe Glykolyse von menschlichen Hirntumoren und darüber liegendem Cortex in vitro. Acta Neurochir., Wien, Suppl. VI (1959), 211–218.

    Google Scholar 

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Herrn Prof. Dr.P. Röttgen zum 60. Geburtstag gewidmet.

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Dohr, H., Heußen, B., Scheithauor-Hoffmann, E. et al. Lactat in Hirntumoren. Acta neurochir 22, 79–84 (1970). https://doi.org/10.1007/BF01406770

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  • DOI: https://doi.org/10.1007/BF01406770

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