Summary
46 patients treated by operative neurosurgery for spontaneous subarachnoid haemorrhage, intracranial tumour and spinal diseases were studied. Levels of circulating immunoglobulin and complement were measured pre-operatively and serially in the first 10 post-operative days.
Prior to operation immunoglobulin levels in all categories of patients were distributed normally. However, immediately post-operatively IgG and IgM fell sharply. Conversely IgA rose in a marked manner and C3 levels showed a gradual increase. Later, antibody levels tended to return to normal.
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Seeldrayers, P.A., Hoyle, N.R. & Thomas, D.G.T. Pre- and post-operative changes in serum immunoglobulin level in neurosurgical patients. Acta neurochir 70, 269–274 (1984). https://doi.org/10.1007/BF01406655
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DOI: https://doi.org/10.1007/BF01406655