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Treatment of malignant brain tumours with ACNU and phenobarbital: Continuous infusion of ACNU into internal carotid artery and systemic administration of phenobarbital

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Summary

Thirteen patients with malignant brain tumours were treated by continuous intra-carotid infusion of ACNU in combination with systemic administration of phenobarbital. This aimed to maintain an ACNU concentration around the tumour cells higher for a relatively longer period and to make an ACNU concentration in the systemic circulation lower. Improvements on clinical states and CT findings were observed in 10 patients. The protective effect of phenobarbital against bone marrow suppression by ACNU was also suggested in this study. No complications were experienced in this treatment.

This results strongly suggested that this technique is useful to treat patients with malignant brain tumours.

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References

  1. Cooperative study group of phase I study on ACNU: Phase I study of 1-(4-amino-2-methyl-5-pyrimidmyl)methyl-3-(2-chloroethyl-3-nitrosourea hydrochloride (ACNU). Jap. J. Clin. Oncol.6 (1976), 55–61.

    Google Scholar 

  2. Greenberg, H. S., Ensminger, W. D., Seeger, J. F., Kindt, G. W., Chandler, W. F., Doan, K., Dakhil, S. R., Intra-arterial BCNU chemotherapy for the treatment of malignant glioma of the central nervous system; A preliminary report. Cancer Treat. Rep.65 (1981), 803–810.

    PubMed  Google Scholar 

  3. Hasegawa, H., Hayakawa, T., Hori, M., Nakagawa, H., Mogami, H., Nakata, Y., Chemotherapy of experimental glioma with nitrosourea; Comparison of water soluble ACNU and lipid soluble Me-CCNU. Brain Nerve29 (1977), 891–898.

    PubMed  Google Scholar 

  4. Hill, D. L., Kirk, M. C., Struck, R. F., Microsomal metabolism of nitrosoureas. Cancer Res.35 (1975), 296–301.

    PubMed  Google Scholar 

  5. Levin, V. A., Stearns, J., Byrd, A., Finn, A., Weinkam, R. J., The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea (PCNU) and on the plasma pharmacokinetics and niotransformation of BCNU. J. Pharmacol. exp. Ther.208 (1979), 1–6.

    PubMed  Google Scholar 

  6. May, H. E., Boose, R., Reed, D. J.; Hydrolxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsome. Biochem. Biophys. Res. Commun.57 (1974), 426–433.

    PubMed  Google Scholar 

  7. Muller, P. J., Tator, C. H., Bloom, M., The effect of phenobarbital on the toxicity and tumourcidal activity of CCNU in a murine tumour model. J. Neurosurg.52 (1980), 359–366.

    PubMed  Google Scholar 

  8. Neuwelt, E. A., Maravilla, K. R., Frenkel, E. P., Barnett, P., Hill, S., Moore, R. J., Use of enhanced computerized tomography to evaluate osmotic blood brain barrier disruption. Neurosurg.6 (1980), 49–56.

    Google Scholar 

  9. Wassemann, T. H., Slavic, M., Carter, S. K., Clinical comparison of nitrosoureas. Cancer36 (1975), 1256–1268.

    Google Scholar 

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Author notes

  1. K. Yumitori

    Present address: Department of Neurosurgery, Kyoto City Hospital, Kyoto, Japan

Authors and Affiliations

  1. Department of Neurosurgery, Kyoto City Hospital, Kyoto, Japan

    T. Teraura

  2. Department of Neurosurgery, Kyoto University, Kyoto, Japan

    H. Handa & J. Yamashita

Authors
  1. K. Yumitori
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  2. T. Teraura
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  3. H. Handa
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  4. J. Yamashita
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Yumitori, K., Teraura, T., Handa, H. et al. Treatment of malignant brain tumours with ACNU and phenobarbital: Continuous infusion of ACNU into internal carotid artery and systemic administration of phenobarbital. Acta neurochir 70, 155–168 (1984). https://doi.org/10.1007/BF01406646

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  • DOI: https://doi.org/10.1007/BF01406646

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